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Synovial high endothelial venules (HEV) supported the binding of normal peripheral blood lymphocytes in vitro. The characteristics of this binding, which were similar to those of lymphocyte-HEV interactions controlling lymphocyte migration into organized lymphoid tissues, included a requirement for calcium ions, a dependence on metabolic activity, and a preferential adherence of circulating lymphocytes as opposed to immature thymocytes. However, the binding of lymphocytes to synovial HEV was not inhibited by a monoclonal antibody to lymphocyte receptors for lymph node HEV, and synovial HEV failed to bind either lymph node HEV-specific or mucosal HEV-specific B lymphoblastoid cells. The results suggest that a lymphocyte-endothelial cell recognition system that is distinct from such systems in organized lymphoid tissues directs the extravasation of normal lymphocytes as well as pathologically important effector cells into inflamed synovium.<\/jats:p>","DOI":"10.1126\/science.3726548","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T20:28:52Z","timestamp":1160080132000},"page":"556-558","source":"Crossref","is-referenced-by-count":221,"title":["A Distinct Endothelial Cell Recognition System That Controls Lymphocyte Traffic into Inflamed Synovium"],"prefix":"10.1126","volume":"233","author":[{"given":"S.","family":"Jalkanen","sequence":"first","affiliation":[{"name":"Department of Pathology, Stanford University Medical Center, Stanford, CA 94305, and the Palo Alto Veterans Administration Medical Center, Palo Alto, CA 94304."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. C.","family":"Steere","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. I.","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Research, Scripps Clinic and Research Foundation, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. C.","family":"Butcher","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University Medical Center, Stanford, CA 94305, and the Palo Alto Veterans Administration Medical Center, Palo Alto, CA 94304."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/978-3-642-71272-2_3","volume":"128","year":"1986","unstructured":"Butcher, E. 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