{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T23:16:37Z","timestamp":1788045397924,"version":"build-2784847793"},"reference-count":22,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4739","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1986,2,14]]},"abstract":"<jats:p>\n            Ivermectin, given to onchocerciasis patients as a single oral dose of 200 micrograms per kilogram of body weight, substantially reduced the uptake of\n            <jats:italic>Onchocerca volvulus<\/jats:italic>\n            microfilariae by\n            <jats:italic>Simulium yahense<\/jats:italic>\n            , an efficient black fly vector of the parasite in the tropical rain forests of West Africa. Three months after treatment, patients given ivermectin infected flies at a significantly lower rate than those who had received diethylcarbamazine or placebo, thereby reducing the number of developing larvae in the vector population. This diminished rate of infectiousness was also evident 6 months after treatment. These results strongly suggest that ivermectin could be effective in interrupting transmission of\n            <jats:italic>Onchocerca volvulus<\/jats:italic>\n            for epidemiologically important periods of time.\n          <\/jats:p>","DOI":"10.1126\/science.3753801","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T20:28:52Z","timestamp":1160080132000},"page":"740-742","source":"Crossref","is-referenced-by-count":67,"title":["The Effects of Ivermectin on Transmission of\n            <i>Onchocerca volvulus<\/i>"],"prefix":"10.1126","volume":"231","author":[{"given":"E. W.","family":"Cupp","sequence":"first","affiliation":[{"name":"Department of Entomology, Cornell University, Ithaca, NY 14853."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Bernardo","sequence":"additional","affiliation":[{"name":"Department of Entomology, Cornell University, Ithaca, NY 14853."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. E.","family":"Kiszewski","sequence":"additional","affiliation":[{"name":"Department of Entomology, Cornell University, Ithaca, NY 14853."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. C.","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Entomology, Cornell University, Ithaca, NY 14853."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. R.","family":"Taylor","sequence":"additional","affiliation":[{"name":"International Center for Epidemiologic and Preventive Ophthamology, Wilmer Ophthamologic Institute, Baltimore, MD 21205."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Aziz","sequence":"additional","affiliation":[{"name":"Merck, Sharp, and Dohme Research Laboratories, Rahway, NJ 07065."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. M.","family":"Greene","sequence":"additional","affiliation":[{"name":"Department of Medicine, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH 44106."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1136\/bjo.62.7.450","volume":"62","year":"1978","unstructured":"ANDERSON, J, FURTHER-STUDIES ON TREATMENT OF OCULAR ONCHOCERCIASIS WITH DIETHYLCARBAMAZINE AND SURAMIN, BRITISH JOURNAL OF OPHTHALMOLOGY 62: 450 (1978).","journal-title":"BRITISH JOURNAL OF OPHTHALMOLOGY"},{"key":"e_1_2_1_2_1","first-page":"171","volume":"2","year":"1982","unstructured":"AZIZ, M.A., EFFICACY AND TOLERANCE OF IVERMECTIN IN HUMAN ONCHOCERCIASIS, LANCET 2: 171 (1982).","journal-title":"LANCET"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.4269\/ajtmh.1984.33.403","volume":"33","year":"1984","unstructured":"BARBIERO, V.K., THE PREVALENCE OF ONCHOCERCIASIS ON SELECTED DIVISIONS OF THE FIRESTONE RUBBER PLANTATION, HARBEL, LIBERIA, AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 33: 403 (1984).","journal-title":"AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE"},{"key":"e_1_2_1_4_1","unstructured":"BUCK A.A. ONCHOCERCIASIS SYMPT (1974)."},{"key":"e_1_2_1_5_1","first-page":"475","volume":"31","year":"1980","unstructured":"CAMPBELL, C.C., QUANTITATIVE ASPECTS OF THE INFECTION OF SIMULIUM OCHRACEUM BY ONCHOCERCA-VOLVULUS - THE RELATION OF SKIN MICROFILARIAL DENSITY TO VECTOR INFECTION, TROPENMEDIZIN UND PARASITOLOGIE 31: 475 (1980).","journal-title":"TROPENMEDIZIN UND PARASITOLOGIE"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6308762"},{"key":"e_1_2_1_7_1","first-page":"471","volume":"302","year":"1983","unstructured":"CHEKE, R.A., REINFESTATIONS OF THE SOUTHEASTERN FLANK OF THE ONCHOCERCIASIS CONTROL PROGRAM AREA BY WINDBORNE VECTORS, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES 302: 471 (1983).","journal-title":"PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES"},{"key":"e_1_2_1_8_1","first-page":"235","volume":"28","year":"1977","unstructured":"COLLINS, R.C., QUANTITATIVE ASPECTS OF INFECTION OF SIMULIUM-OCHRCEUM BY ONCHOCERCA-VOLVULUS, TROPENMEDIZIN UND PARASITOLOGIE 28: 235 (1977).","journal-title":"TROPENMEDIZIN UND PARASITOLOGIE"},{"key":"e_1_2_1_9_1","first-page":"466","volume":"38","year":"1978","unstructured":"DAVIES, J.B., ONCHOCERCIASIS AND SIMULIUM CONTROL IN THE VOLTA RIVER BASIN, MOSQUITO NEWS 38: 466 (1978).","journal-title":"MOSQUITO NEWS"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1080\/00034983.1962.11686118","volume":"56","year":"1962","unstructured":"DUKE, BOL, STUDIES ON FACTORS INFLUENCING TRANSMISSION OF ONCHOCERCIASIS .2. INTAKE OF ONCHOCERCA-VOLVULUS MICROFILARIAE BY SIMULIUM-DAMNOSUM AND SURVIVAL OF PARASITES IN FLY UNDER LABORATORY CONDITIONS, ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY 56: 255 (1962).","journal-title":"ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY"},{"key":"e_1_2_1_11_1","first-page":"169","volume":"39","year":"1968","unstructured":"DUKE, BOL, INTAKE AND TRANSMISSIBILITY OF ONCHOCERCA VOLVULUS MICROFILARIAE BY SIMULIUM DAMNOSUM FED ON PATIENTS TREATED WITH DIETHYLCARBAMAZINE SURAMIN OR MEL W, BULLETIN OF THE WORLD HEALTH ORGANIZATION 39: 169 (1968).","journal-title":"BULLETIN OF THE WORLD HEALTH ORGANIZATION"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1136\/bmj.283.6297.961","volume":"283","year":"1981","unstructured":"DUKE, B.O., THE 6 DISEASES OF WHO - ONCHOCERCIASIS, BRITISH MEDICAL JOURNAL 283: 961 (1981).","journal-title":"BRITISH MEDICAL JOURNAL"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/oxfordjournals.bmb.a070896","volume":"28","year":"1972","unstructured":"DUKE, BOL, ONCHOCERCIASIS, BRITISH MEDICAL BULLETIN 28: 66 (1972).","journal-title":"BRITISH MEDICAL BULLETIN"},{"key":"e_1_2_1_14_1","first-page":"143","volume":"26","year":"1975","unstructured":"DUKE, BOL, ONCHOCERCA-VOLVULUS TRANSMISSION POTENTIALS AND ASSOCIATED PATTERNS OF ONCHOCERCIASIS AT 4 CAMEROON SUDAN-SAVANNA VILLAGES, TROPENMEDIZIN UND PARASITOLOGIE 26: 143 (1975).","journal-title":"TROPENMEDIZIN UND PARASITOLOGIE"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1056\/NEJM198507183130301","volume":"313","year":"1985","unstructured":"GREENE, B.M., COMPARISON OF IVERMECTIN AND DIETHYLCARBAMAZINE IN THE TREATMENT OF ONCHOCERCIASIS, NEW ENGLAND JOURNAL OF MEDICINE 313: 133 (1985).","journal-title":"NEW ENGLAND JOURNAL OF MEDICINE"},{"key":"e_1_2_1_16_1","first-page":"413","year":"1984","unstructured":"GREENE, B.M., TROPICAL GEOGRAPHICA: 413 (1984).","journal-title":"TROPICAL GEOGRAPHICA"},{"key":"e_1_2_1_17_1","first-page":"166","volume":"3","year":"1954","unstructured":"IKEJIANI, O, WEST AFRICAN MEDICAL JOURNAL 3: 166 (1954).","journal-title":"WEST AFRICAN MEDICAL JOURNAL"},{"key":"e_1_2_1_18_1","first-page":"518","volume":"44","year":"1984","unstructured":"KURTAK, D, DETECTION OF RESISTANCE TO TEMEPHOS AND CHLORPHOXIM IN SIMULIUM-DAMNOSUM SL BY TOPICAL APPLICATION TO ADULTS, MOSQUITO NEWS 44: 518 (1984).","journal-title":"MOSQUITO NEWS"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/jmedent\/16.1.48","volume":"16","year":"1979","unstructured":"SHELLEY, A.J., CONCENTRATION OF MICROFILARIAE OF ONCHOCERCA-VOLVULUS BY SIMULIUM-SANGUINEUM DURING FEEDING - USE IN MAPPING PARASITE DISTRIBUTION IN THE SKIN, JOURNAL OF MEDICAL ENTOMOLOGY 16: 48 (1979).","journal-title":"JOURNAL OF MEDICAL ENTOMOLOGY"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.4269\/ajtmh.1981.30.1121","volume":"30","year":"1981","unstructured":"TAKAOKA, H, SEASONAL OCCURRENCE OF SIMULIUM-OCHRACEUM, THE PRINCIPAL VECTOR OF ONCHOCERCA-VOLVULUS IN THE SOUTHEASTERN ENDEMIC AREA OF GUATEMALA, AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 30: 1121 (1981).","journal-title":"AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE"},{"key":"e_1_2_1_21_1","first-page":"346","volume":"29","year":"1978","unstructured":"THYLEFORS, B, TRANSMISSION POTENTIALS OF ONCHOCERCA-VOLVULUS AND ASSOCIATED INTENSITY OF ONCHOCERCIASIS IN A SUDAN-SAVANNA AREA, TROPENMEDIZIN UND PARASITOLOGIE 29: 346 (1978).","journal-title":"TROPENMEDIZIN UND PARASITOLOGIE"},{"key":"e_1_2_1_22_1","first-page":"145","volume":"17","year":"1979","unstructured":"TOWNSON, H, SYMPOSIA OF THE BRITISH SOCIETY FOR PARASITOLOGY 17: 145 (1979).","journal-title":"SYMPOSIA OF THE BRITISH SOCIETY FOR PARASITOLOGY"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.3753801","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T09:22:19Z","timestamp":1705224139000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.3753801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,2,14]]},"references-count":22,"journal-issue":{"issue":"4739","published-print":{"date-parts":[[1986,2,14]]}},"alternative-id":["10.1126\/science.3753801"],"URL":"https:\/\/doi.org\/10.1126\/science.3753801","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,2,14]]}}}