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The observed ratio agrees with an estimate of its value calculated from the geometric properties of helical assemblies and the degree of distortion that a protein-protein interface can undergo. This agreement indicates that the radius of an aggregate is limited by the maximum possible stretching of double strands. The geometric properties limiting the radial extent of sickle hemoglobin fibers are fundamental to all cables of protein filaments and could contribute to the control of diameter in other biological fibers such as collagen or fibrin.<\/jats:p>","DOI":"10.1126\/science.3775381","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T20:28:52Z","timestamp":1160080132000},"page":"1228-1231","source":"Crossref","is-referenced-by-count":29,"title":["Polymorphism of Sickle Cell Hemoglobin Aggregates: Structural Basis for Limited Radial Growth"],"prefix":"10.1126","volume":"234","author":[{"given":"Lee","family":"Makowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Magdoff-Fairchild","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/SQB.1962.027.001.005","volume":"27","year":"1962","unstructured":"CASPAR, DLD, PHYSICAL PRINCIPLES IN CONSTRUCTION OF REGULAR VIRUSES, COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY 27: 1 (1962).","journal-title":"COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/0022-2836(80)90401-5","volume":"136","year":"1980","unstructured":"CHIU, C.C., DEOXYGENATED SICKLE HEMOGLOBIN - PHASE-TRANSFORMATION FROM FIBER TO A NEW MONOCLINIC CRYSTALLINE FORM, JOURNAL OF MOLECULAR BIOLOGY 136: 455 (1980).","journal-title":"JOURNAL OF MOLECULAR BIOLOGY"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/256705a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/302500a0","volume":"302","year":"1983","unstructured":"CHOTHIA, C, TRANSMISSION OF CONFORMATIONAL CHANGE IN INSULIN, NATURE 302: 500 (1983).","journal-title":"NATURE"},{"key":"e_1_2_1_5_1","first-page":"1406","volume":"78","year":"1981","unstructured":"CREPEAU, R.H., SICKLE-CELL HEMOGLOBIN FIBER STRUCTURE ALTERED BY ALPHA-CHAIN MUTATION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 78: 1406 (1981).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0365110X53001964"},{"key":"e_1_2_1_7_1","unstructured":"Dickerson R. 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