{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:12:34Z","timestamp":1771643554630,"version":"3.50.1"},"reference-count":13,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4781","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1986,12,5]]},"abstract":"<jats:p>New methods were used to identify the abnormality in a patient who showed evidence of neuromuscular dysfunction on extensive clinical examination. The methods revealed that the lactate content of the patient's skeletal muscle does not decline normally after exercise and that his red cells are defective in lactate transport. These results suggest that skeletal muscle and erythrocyte membranes share the same genetic lactate transporter (or a common subunit), which is deficient in this patient. This defect may be a common cause of elevated serum creatine kinase levels, as seen in the patient described here and of unexplained episodes of rhabdomyolysis and myoglobinuria.<\/jats:p>","DOI":"10.1126\/science.3775384","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T20:28:52Z","timestamp":1160080132000},"page":"1254-1256","source":"Crossref","is-referenced-by-count":58,"title":["Lactate Transporter Defect: A New Disease of Muscle"],"prefix":"10.1126","volume":"234","author":[{"given":"William N.","family":"Fishbein","sequence":"first","affiliation":[{"name":"Biochemistry Division, Armed Forces Institute of Pathology, Washington, DC 20306-6000."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","unstructured":"Astrand P.-O. Textbook of Work Physiology 2 (1977)."},{"key":"e_1_2_1_2_1","first-page":"93","year":"1976","unstructured":"BANKS, P, BIOCH TISSUES: 93 (1976).","journal-title":"BIOCH TISSUES"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/0005-2736(82)90053-0","volume":"684","year":"1982","unstructured":"DEUTICKE, B, DISCRIMINATION OF 3 PARALLEL PATHWAYS OF LACTATE TRANSPORT IN THE HUMAN-ERYTHROCYTE MEMBRANE BY INHIBITORS AND KINETIC-PROPERTIES, BIOCHIMICA ET BIOPHYSICA ACTA 684: 96 (1982).","journal-title":"BIOCHIMICA ET BIOPHYSICA ACTA"},{"key":"e_1_2_1_4_1","first-page":"539","year":"1980","unstructured":"DEUTICKE, B, MEMBRANE TRANSPORT E: 539 (1980).","journal-title":"MEMBRANE TRANSPORT E"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1126\/science.6262916","volume":"212","year":"1981","unstructured":"DIMAURO, S, HUMAN-MUSCLE PHOSPHOGLYCERATE MUTASE DEFICIENCY - NEWLY DISCOVERED METABOLIC MYOPATHY, SCIENCE 212: 1277 (1981).","journal-title":"SCIENCE"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/BF01940571","volume":"44","year":"1978","unstructured":"DUBINSKY, W.P., MECHANISM OF LACTATE TRANSPORT IN HUMAN ERYTHROCYTES, JOURNAL OF MEMBRANE BIOLOGY 44: 25 (1978).","journal-title":"JOURNAL OF MEMBRANE BIOLOGY"},{"key":"e_1_2_1_7_1","first-page":"1745","volume":"2","year":"1986","unstructured":"FISHBEIN, W.N., MYOLOGY 2: 1745 (1986).","journal-title":"MYOLOGY"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.644316"},{"key":"e_1_2_1_9_1","first-page":"13","volume":"10","year":"1951","unstructured":"MCCARDLE, B, CLIN SCI 10: 13 (1951).","journal-title":"CLIN SCI"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0022-510X(83)90111-9","volume":"58","year":"1983","unstructured":"MILLS, K.R., INVESTIGATIVE STRATEGIES FOR MUSCLE PAIN, JOURNAL OF THE NEUROLOGICAL SCIENCES 58: 73 (1983).","journal-title":"JOURNAL OF THE NEUROLOGICAL SCIENCES"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","unstructured":"Peachey L. D. Handbook of Physiology (1983).","DOI":"10.1002\/cphy.cp1001fm01"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1042\/bj1540405","volume":"154","year":"1976","unstructured":"SPENCER, T.L., L-LACTATE TRANSPORT IN EHRLICH ASCITES-TUMOR CELLS, BIOCHEMICAL JOURNAL 154: 405 (1976).","journal-title":"BIOCHEMICAL JOURNAL"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/0006-291X(65)90156-7","volume":"19","year":"1965","unstructured":"TARUI, S, PHOSPHOFRUCTOKINASE DEFICIENCY IN SKELETAL MUSCLE - A NEW TYPE OF GLYCOGENOSIS, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 19: 517 (1965).","journal-title":"BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.3775384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T10:18:27Z","timestamp":1705227507000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.3775384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,12,5]]},"references-count":13,"journal-issue":{"issue":"4781","published-print":{"date-parts":[[1986,12,5]]}},"alternative-id":["10.1126\/science.3775384"],"URL":"https:\/\/doi.org\/10.1126\/science.3775384","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,12,5]]}}}