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HER-2\/\n                    <jats:italic>neu<\/jats:italic>\n                    was found to be amplified from 2- to greater than 20-fold in 30% of the tumors. Correlation of gene amplification with several disease parameters was evaluated. Amplification of the HER-2\/\n                    <jats:italic>neu<\/jats:italic>\n                    gene was a significant predictor of both overall survival and time to relapse in patients with breast cancer. It retained its significance even when adjustments were made for other known prognostic factors. Moreover, HER-2\/\n                    <jats:italic>neu<\/jats:italic>\n                    amplification had greater prognostic value than most currently used prognostic factors, including hormonal-receptor status, in lymph node-positive disease. These data indicate that this gene may play a role in the biologic behavior and\/or pathogenesis of human breast cancer.\n                  <\/jats:p>","DOI":"10.1126\/science.3798106","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T16:28:58Z","timestamp":1160065738000},"page":"177-182","source":"Crossref","is-referenced-by-count":9571,"title":["Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2\/\n                    <i>neu<\/i>\n                    Oncogene"],"prefix":"10.1126","volume":"235","author":[{"given":"Dennis J.","family":"Slamon","sequence":"first","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine and Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, CA 90024."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary M.","family":"Clark","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78284."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven G.","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine and Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, CA 90024."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy J.","family":"Levin","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine and Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, CA 90024."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Ullrich","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Genentech, Inc., South San Francisco, CA 94080."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L.","family":"McGuire","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78284."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90779-8"},{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.52.070183.001505"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2307\/1402659","volume":"43","year":"1975","unstructured":"BRESLOW, N.E., ANALYSIS OF SURVIVAL DATA UNDER PROPORTIONAL HAZARDS MODEL, INTERNATIONAL STATISTICAL REVIEW 43: 45 (1975).","journal-title":"INTERNATIONAL STATISTICAL REVIEW"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6719137"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0092-8674(83)90417-8","volume":"33","year":"1983","unstructured":"CAMPISI, J, CELL 33: 357 (1983).","journal-title":"CELL"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1056\/NEJM198312013092240","volume":"309","year":"1983","unstructured":"CLARK, G.M., PROGESTERONE RECEPTORS AS A PROGNOSTIC FACTOR IN STAGE-II BREAST-CANCER, NEW ENGLAND JOURNAL OF MEDICINE 309: 1343 (1983).","journal-title":"NEW ENGLAND JOURNAL OF MEDICINE"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2999974"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","volume":"34","year":"1972","unstructured":"COX, D.R., REGRESSION MODELS AND LIFE-TABLES, JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY 34: 187 (1972).","journal-title":"JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY"},{"key":"e_1_2_1_9_1","first-page":"54","volume":"252","year":"1985","unstructured":"CROCE, C.M., CHROMOSOME TRANSLOCATIONS AND HUMAN CANCER, SCIENTIFIC AMERICAN 252: 54 (1985).","journal-title":"SCIENTIFIC AMERICAN"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0006-291X(86)80333-3","volume":"141","year":"1986","unstructured":"Dizikes, G. 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