{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:07:50Z","timestamp":1770505670735,"version":"3.49.0"},"reference-count":26,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4691","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1985,3,8]]},"abstract":"<jats:p>\n            Mechanisms that affect the transcription of the c-\n            <jats:italic>myc<\/jats:italic>\n            oncogene take part in the development of B-cell neoplasias such as Burkitt's lymphoma. Daudi Burkitt lymphoma cells, which express only the translocated c-\n            <jats:italic>myc<\/jats:italic>\n            oncogene, were hybridized with human lymphoblastoid cells, which express the normal c-\n            <jats:italic>myc<\/jats:italic>\n            gene; the hybrids were phenotypically lymphoblastoid and expressed both the translocated and the normal c-\n            <jats:italic>myc<\/jats:italic>\n            gene. This result contrasts with the findings that the decapitated c-\n            <jats:italic>myc<\/jats:italic>\n            gene, translocated to an immunoglobulin switch \u03bc or \u03b1 region, is transcriptionally silent in lymphoblastoid hybrids. Thus, there may be at least two distinct enhancer-like elements capable of deregulating c-\n            <jats:italic>myc<\/jats:italic>\n            transcription in lymphomas and leukemias with t(8;14) chromosome translocations. In addition, since the Daudi \u00d7 lymphoblastoid hybrids express both the translocated and the normal c-\n            <jats:italic>myc<\/jats:italic>\n            gene, the c-\n            <jats:italic>myc<\/jats:italic>\n            gene product does not autoregulate c-\n            <jats:italic>myc<\/jats:italic>\n            transcription.\n          <\/jats:p>","DOI":"10.1126\/science.3856319","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T19:42:50Z","timestamp":1160077370000},"page":"1235-1238","source":"Crossref","is-referenced-by-count":15,"title":["Coexpression of Translocated and Normal c-\n            <i>myc<\/i>\n            Oncogenes in Hybrids Between Daudi and Lymphoblastoid Cells"],"prefix":"10.1126","volume":"227","author":[{"given":"Carlo M.","family":"Croce","sequence":"first","affiliation":[{"name":"Wistar Institute, Philadelphia, Pennsylvania 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Erikson","sequence":"additional","affiliation":[{"name":"Wistar Institute, Philadelphia, Pennsylvania 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kay","family":"Huebner","sequence":"additional","affiliation":[{"name":"Wistar Institute, Philadelphia, Pennsylvania 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuko","family":"Nishikura","sequence":"additional","affiliation":[{"name":"Wistar Institute, Philadelphia, Pennsylvania 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/BF01538674","volume":"8","year":"1982","unstructured":"ARRUSHDI, A, TRANSCRIPTIONAL CONTROL OF THE EXPRESSION OF MOUSE GLOBIN GENES IN MYELOMA X ERYTHROLEUKEMIA CELL HYBRIDS, SOMATIC CELL GENETICS 8: 151 (1982).","journal-title":"SOMATIC CELL GENETICS"},{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6414084"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0165-4608(81)90039-X","volume":"3","year":"1981","unstructured":"BERNHEIM, A, CYTOGENETIC STUDIES ON AFRICAN BURKITTS-LYMPHOMA CELL-LINES - 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