{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:21:56Z","timestamp":1792790516862,"version":"4.5.0"},"reference-count":20,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4696","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1985,4,12]]},"abstract":"<jats:p>The time constant of the decay of slow-phase eye velocity of postrotatory nystagmus or optokinetic after-nystagmus is reduced during exposure to a stationary visual surround (visual suppression). It is also reduced after tilting the head (tilt suppression). A \"dump\" mechanism in the vestibulo-ocular reflex has been proposed to rapidly discharge activity from the central vestibular system during both types of suppression. Monkeys lost this mechanism after lesions of the nodulus and uvula. They also lost the ability to habituate the time constant of nystagmus on repeated exposure to optokinetic and vestibular stimuli. Periodic alternating nystagmus, which is believed to represent an instability in the vestibulo-ocular reflex, was observed in two of three monkeys. These data indicate that the nodulus and uvula play an important role in suppressing, habituating, and stabilizing the vestibulo-ocular reflex.<\/jats:p>","DOI":"10.1126\/science.3871968","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T15:42:50Z","timestamp":1160062970000},"page":"199-202","source":"Crossref","is-referenced-by-count":340,"title":["Dynamic Modification of the Vestibulo-Ocular Reflex by the Nodulus and Uvula"],"prefix":"10.1126","volume":"228","author":[{"given":"Walter","family":"Waespe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore","family":"Raphan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"441","volume":"105","year":"1967","unstructured":"ANGAUT, P, ARCH ITAL BIOL 105: 441 (1967).","journal-title":"ARCH ITAL BIOL"},{"key":"e_1_2_1_2_1","first-page":"144","volume":"37","year":"1966","unstructured":"BENSON, A.J., INTERACTION OF LINEAR AND ANGULAR ACCELERATIONS ON VESTIBULAR RECEPTORS IN MAN, AEROSPACE MEDICINE 37: 144 (1966).","journal-title":"AEROSPACE MEDICINE"},{"key":"e_1_2_1_3_1","first-page":"310","volume":"41","year":"1981","unstructured":"BUETTNER, U, EXPERIMENTAL BRAIN RESEARCH 41: 310 (1981).","journal-title":"EXPERIMENTAL BRAIN RESEARCH"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1113\/jphysiol.1977.sp011955","volume":"270","year":"1977","unstructured":"COHEN, B, QUANTITATIVE-ANALYSIS OF VELOCITY CHARACTERISTICS OF OPTOKINETIC NYSTAGMUS AND OPTOKINETIC AFTER-NYSTAGMUS, JOURNAL OF PHYSIOLOGY-LONDON 270: 321 (1977).","journal-title":"JOURNAL OF PHYSIOLOGY-LONDON"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3109\/00016486509126986","volume":"60","year":"1965","unstructured":"GUEDRY, F.E., ACTA OTO-LARYNGOLOGICA 60: 30 (1965).","journal-title":"ACTA OTO-LARYNGOLOGICA"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/ana.410080611","volume":"8","year":"1980","unstructured":"HALMAGYI, G.M., TREATMENT OF PERIODIC ALTERNATING NYSTAGMUS, ANNALS OF NEUROLOGY 8: 609 (1980).","journal-title":"ANNALS OF NEUROLOGY"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1152\/ajplegacy.1937.120.2.350","volume":"120","year":"1937","unstructured":"HALSTEAD, W, Further evidence of cerebellar influence in the habituation of after-nystagmus in pigeons, AMERICAN JOURNAL OF PHYSIOLOGY 120: 350 (1937).","journal-title":"AMERICAN JOURNAL OF PHYSIOLOGY"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/j.1749-6632.1981.tb30906.x","volume":"374","year":"1981","unstructured":"LEIGH, R.J., A HYPOTHETICAL EXPLANATION FOR PERIODIC ALTERNATING NYSTAGMUS - INSTABILITY IN THE OPTOKINETIC-VESTIBULAR SYSTEM, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 374: 619 (1981).","journal-title":"ANNALS OF THE NEW YORK ACADEMY OF SCIENCES"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1152\/jn.1978.41.3.764","volume":"41","year":"1978","unstructured":"LISBERGER, S.G., ROLE OF PRIMATE FLOCCULUS DURING RAPID BEHAVIORAL MODIFICATION OF VESTIBULOOCULAR REFLEX .2. MOSSY FIBER FIRING PATTERNS DURING HORIZONTAL HEAD ROTATION AND EYE-MOVEMENT, JOURNAL OF NEUROPHYSIOLOGY 41: 764 (1978).","journal-title":"JOURNAL OF NEUROPHYSIOLOGY"},{"key":"e_1_2_1_10_1","first-page":"197","volume":"53","year":"1984","unstructured":"MATSUO, V, VERTICAL OPTOKINETIC NYSTAGMUS AND VESTIBULAR-NYSTAGMUS IN THE MONKEY - UP-DOWN ASYMMETRY AND EFFECTS OF GRAVITY, EXPERIMENTAL BRAIN RESEARCH 53: 197 (1984).","journal-title":"EXPERIMENTAL BRAIN RESEARCH"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1083068"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0306-4522(76)90057-9","volume":"1","year":"1976","unstructured":"PRECHT, W, EFFECTS OF STIMULATING CEREBELLAR NODULUS IN CAT ON RESPONSES OF VESTIBULAR NEURONS, NEUROSCIENCE 1: 301 (1976).","journal-title":"NEUROSCIENCE"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/0306-4522(80)90170-0","volume":"5","year":"1980","unstructured":"PRECHT, W, ON THE PATHWAY MEDIATING OPTOKINETIC RESPONSES IN VESTIBULAR NUCLEAR NEURONS, NEUROSCIENCE 5: 777 (1980).","journal-title":"NEUROSCIENCE"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1749-6632.1981.tb30859.x","volume":"374","year":"1981","unstructured":"RAPHAN, T, EFFECTS OF GRAVITY ON ROTATORY NYSTAGMUS IN MONKEYS, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 374: 44 (1981).","journal-title":"ANNALS OF THE NEW YORK ACADEMY OF SCIENCES"},{"key":"e_1_2_1_15_1","first-page":"229","volume":"35","year":"1979","unstructured":"RAPHAN, T, VELOCITY STORAGE IN THE VESTIBULO-OCULAR REFLEX ARC (VOR), EXPERIMENTAL BRAIN RESEARCH 35: 229 (1979).","journal-title":"EXPERIMENTAL BRAIN RESEARCH"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1288\/00005537-196709000-00001","volume":"77","year":"1967","unstructured":"SINGLETON, G.T., RELATIONSHIPS OF CEREBELLAR NODULUS TO VESTIBULAR FUNCTION - A STUDY OF EFFECTS OF NODULECTOMY ON HABITUATION, LARYNGOSCOPE 77: 1579 (1967).","journal-title":"LARYNGOSCOPE"},{"key":"e_1_2_1_17_1","first-page":"323","volume":"30","year":"1977","unstructured":"WAESPE, W, VESTIBULAR NUCLEI ACTIVITY DURING OPTOKINETIC AFTER-NYSTAGMUS (OKAN) IN ALERT MONKEY, EXPERIMENTAL BRAIN RESEARCH 30: 323 (1977).","journal-title":"EXPERIMENTAL BRAIN RESEARCH"},{"key":"e_1_2_1_18_1","first-page":"9","volume":"50","year":"1983","unstructured":"WAESPE, W, ROLE OF THE FLOCCULUS AND PARAFLOCCULUS IN OPTOKINETIC NYSTAGMUS AND VISUAL-VESTIBULAR INTERACTIONS - EFFECTS OF LESIONS, EXPERIMENTAL BRAIN RESEARCH 50: 9 (1983).","journal-title":"EXPERIMENTAL BRAIN RESEARCH"},{"key":"e_1_2_1_19_1","first-page":"23","volume":"51","year":"1983","unstructured":"WAESPE, W, FLOCCULECTOMY AND UNIT-ACTIVITY IN THE VESTIBULAR NUCLEI DURING VISUAL-VESTIBULAR INTERACTIONS, EXPERIMENTAL BRAIN RESEARCH 51: 23 (1983).","journal-title":"EXPERIMENTAL BRAIN RESEARCH"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1152\/jn.1981.46.4.878","volume":"46","year":"1981","unstructured":"ZEE, D.S., EFFECTS OF ABLATION OF FLOCCULUS AND PARAFLOCCULUS ON EYE-MOVEMENTS IN PRIMATE, JOURNAL OF NEUROPHYSIOLOGY 46: 878 (1981).","journal-title":"JOURNAL OF NEUROPHYSIOLOGY"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.3871968","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T04:59:40Z","timestamp":1705208380000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.3871968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,4,12]]},"references-count":20,"journal-issue":{"issue":"4696","published-print":{"date-parts":[[1985,4,12]]}},"alternative-id":["10.1126\/science.3871968"],"URL":"https:\/\/doi.org\/10.1126\/science.3871968","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,4,12]]}}}