{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T08:31:03Z","timestamp":1790497863181,"version":"4.1.0"},"reference-count":21,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4712","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1985,8,2]]},"abstract":"<jats:p>\n            \u03b2-galactosidase-deficient siblings in two litters of English springer spaniel puppies showed a progressive neurological impairment, dwarfism, orbital hypertelorism, and dysostosis multiplex. An excess of G\n            <jats:sub>M1<\/jats:sub>\n            -ganglioside was found in the brain. Three abnormal oligosaccharides were present in samples of urine, brain, liver, and cartilage. Light microscopy of selected tissue specimens revealed cytoplasmic vacuoles in neurons, circulating blood cells, macrophages, and chondrocytes. Ultrastructural studies demonstrated that these membrane-bound vacuoles were of two types\u2014one containing lamellated membranes and the other, finely granular material. These clinical and pathological findings are similar to those observed in human patients affected by the infantile form of G\n            <jats:sub>M1<\/jats:sub>\n            -gangliosidosis.\n          <\/jats:p>","DOI":"10.1126\/science.3925555","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T19:42:50Z","timestamp":1160077370000},"page":"470-472","source":"Crossref","is-referenced-by-count":45,"title":["Neurovisceral and Skeletal G\n            <sub>M1<\/sub>\n            -Gangliosidosis in Dogs with \u03b2-Galactosidase Deficiency"],"prefix":"10.1126","volume":"229","author":[{"given":"Joseph","family":"Alroy","sequence":"first","affiliation":[{"name":"Department of Pathology, Tufts University School of Medicine and Veterinary Medicine, Boston, Massachusetts 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uri","family":"Orgad","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tufts University School of Medicine and Veterinary Medicine, Boston, Massachusetts 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo A.","family":"Ucci","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tufts University School of Medicine and Veterinary Medicine, Boston, Massachusetts 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott H.","family":"Schelling","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tufts University School of Medicine and Veterinary Medicine, Boston, Massachusetts 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth L.","family":"Schunk","sequence":"additional","affiliation":[{"name":"Department of Medicine, Tufts University School of Veterinary Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Warren","sequence":"additional","affiliation":[{"name":"Laboratory for Carbohydrate Research, Massachusetts General Hospital, Boston 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasa S.","family":"Raghavan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Eunice Kennedy Shriver Center for Mental Retardation, Waltham, Massachusetts 02254"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin H.","family":"Kolodny","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Eunice Kennedy Shriver Center for Mental Retardation, Waltham, Massachusetts 02254"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"67","year":"1984","unstructured":"ALROY, J, DIAGNOSTIC IMMUNOCHE: 67 (1984).","journal-title":"DIAGNOSTIC IMMUNOCHE"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1177\/32.12.6501863","volume":"32","year":"1984","unstructured":"ALROY, J, IDENTIFICATION OF GLYCOPROTEIN STORAGE DISEASES BY LECTINS - 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