{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T10:07:33Z","timestamp":1759226853337},"reference-count":14,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4697","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1985,4,19]]},"abstract":"<jats:p>\n            Nanomolar concentrations of peptidoleukotrienes evoke sustained cerebral edema and arterial constriction. Peptidoleukotrienes are thus considered to play an important role in eliciting cerebral edema after cerebral ischemia and vasospasm after subarachnoid hemorrhage. It was hypothesized that the choroid plexus, the locus of the blood-cerebrospinal fluid barrier, might minimize the vasoactivity of locally generated or systemically derived leukotrienes by transporting leukotrienes from cerebrospinal fluid into the blood. Consistent with this hypothesis, leukotriene C\n            <jats:sub>4<\/jats:sub>\n            in vitro was transported into and released from isolated rabbit choroid plexus by a system that was specific, energy-dependent, probenecid-sensitive, and depressed by cold temperatures. The accumulation of leukotriene C\n            <jats:sub>4<\/jats:sub>\n            in the choroid plexus was not dependent on tissue binding or metabolism of leukotriene C\n            <jats:sub>4<\/jats:sub>\n            .\n          <\/jats:p>","DOI":"10.1126\/science.3983632","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T19:42:50Z","timestamp":1160077370000},"page":"325-327","source":"Crossref","is-referenced-by-count":26,"title":["Leukotriene C\n            <sub>4<\/sub>\n            Transport by the Choroid Plexus in Vitro"],"prefix":"10.1126","volume":"228","author":[{"given":"Reynold","family":"Spector","sequence":"first","affiliation":[{"name":"Departments of Internal Medicine and Pharmacology, University of Iowa College of Medicine, Iowa City 52242"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward J.","family":"Goetzl","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Microbiology, University of California Medical Center, San Francisco 94143"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0021-9258(19)68396-1","volume":"257","year":"1982","unstructured":"APPLEGREN, L.E., J BIOL CHEM 257: 531 (1982).","journal-title":"J BIOL CHEM"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0262-1746(84)90117-3","volume":"14","year":"1984","unstructured":"BLACK, K.L., LEUKOTRIENE-C4 INDUCES VASOGENIC CEREBRAL EDEMA IN RATS, PROSTAGLANDINS LEUKOTRIENES AND MEDICINE 14: 339 (1984).","journal-title":"PROSTAGLANDINS LEUKOTRIENES AND MEDICINE"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","unstructured":"Bradbury M. The Concept of a Blood-Brain Barrier (1979).","DOI":"10.1016\/0166-2236(79)90016-X"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev.bi.52.070183.002035","volume":"52","year":"1983","unstructured":"HAMMARSTROM, S, LEUKOTRIENES, ANNUAL REVIEW OF BIOCHEMISTRY 52: 355 (1983).","journal-title":"ANNUAL REVIEW OF BIOCHEMISTRY"},{"key":"e_1_2_1_5_1","first-page":"465","volume":"184","year":"1973","unstructured":"LORENZO, A.V., TRANSPORT OF SALICYLIC-ACID BY CHOROID-PLEXUS IN-VITRO, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 184: 465 (1973).","journal-title":"JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/BF00916578","volume":"4","year":"1984","unstructured":"Matthay, M. A., Journal of Clinical Immunology 4: 479 (1984).","journal-title":"Journal of Clinical Immunology"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6719118"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/0006-291X(82)91410-3","volume":"104","year":"1982","unstructured":"ORMSTAD, K, UPTAKE AND METABOLISM OF LEUKOTRIENE C-3 BY ISOLATED RAT ORGANS AND CELLS, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 104: 1434 (1982).","journal-title":"BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1111\/j.1471-4159.1978.tb10798.x","volume":"30","year":"1978","unstructured":"SPECTOR, R, VITAMIN-B6 TRANSPORT IN CENTRAL NERVOUS-SYSTEM - INVITRO STUDIES, JOURNAL OF NEUROCHEMISTRY 30: 889 (1978).","journal-title":"JOURNAL OF NEUROCHEMISTRY"},{"key":"e_1_2_1_10_1","first-page":"55","volume":"188","year":"1974","unstructured":"SPECTOR, R, EFFECTS OF SALICYLATE AND PROBENECID ON CEREBROSPINAL-FLUID TRANSPORT OF PENICILLIN, AMINOSALICYLIC ACID AND IODIDE, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 188: 55 (1974).","journal-title":"JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1056\/NEJM197706162962409","volume":"296","year":"1977","unstructured":"SPECTOR, R, VITAMIN HOMEOSTASIS IN CENTRAL NERVOUS-SYSTEM, NEW ENGLAND JOURNAL OF MEDICINE 296: 1393 (1977).","journal-title":"NEW ENGLAND JOURNAL OF MEDICINE"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1167256"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1111\/j.1471-4159.1983.tb09071.x","volume":"41","year":"1983","unstructured":"SUZUKI, N, IDENTIFICATION OF 5-HYDROXY EICOSATETRAENOIC ACID IN CEREBROSPINAL-FLUID AFTER SUBARACHNOID HEMORRHAGE, JOURNAL OF NEUROCHEMISTRY 41: 1186 (1983).","journal-title":"JOURNAL OF NEUROCHEMISTRY"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0262-1746(83)90041-0","volume":"11","year":"1983","unstructured":"TAGARI, P, LEUKOTRIENE-D4 AND THE CEREBRAL VASCULATURE INVIVO AND INVITRO, PROSTAGLANDINS LEUKOTRIENES AND MEDICINE 11: 281 (1983).","journal-title":"PROSTAGLANDINS LEUKOTRIENES AND MEDICINE"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.3983632","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T10:00:56Z","timestamp":1705226456000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.3983632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,4,19]]},"references-count":14,"journal-issue":{"issue":"4697","published-print":{"date-parts":[[1985,4,19]]}},"alternative-id":["10.1126\/science.3983632"],"URL":"https:\/\/doi.org\/10.1126\/science.3983632","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,4,19]]}}}