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Virus replication occurred in mice injected from 4 days after birth by all inoculation routes, whether or not they were injected with scrapie virus on day 0. The results suggest that scrapie virus replicates peripherally only in thymocytes, which are not present in mice until a few days after birth. The latent state suggests that the comparable human diseases could appear in later life as a result of perinatal infection. In some respects these diseases resemble premature senility.<\/jats:p>","DOI":"10.1126\/science.404706","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T16:03:07Z","timestamp":1160064187000},"page":"668-671","source":"Crossref","is-referenced-by-count":23,"title":["Latent form of Scrapie Virus: A New Factor in Slow-Virus Disease"],"prefix":"10.1126","volume":"196","author":[{"given":"John","family":"Hotchin","sequence":"first","affiliation":[{"name":"Division of Laboratories and Research, New York State Department of Health, Albany 12201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Buckley","sequence":"additional","affiliation":[{"name":"Division of Laboratories and Research, New York State Department of Health, Albany 12201"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/brain\/92.4.699","volume":"92","year":"1969","unstructured":"BECK, E, CREUTZFELDT-JAKOB DISEASE - NEUROPATHOLOGY OF A TRANSMISSION EXPERIMENT, BRAIN 92: 699 (1969).","journal-title":"BRAIN"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1365-2990.1975.tb00388.x","volume":"1","year":"1975","unstructured":"BRUCE, M.E., AMYLOID PLAQUES IN BRAINS OF MICE INFECTED WITH SCRAPIE - MORPHOLOGICAL VARIATION AND STAINING PROPERTIES, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY 1: 189 (1975).","journal-title":"NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/infdis\/128.2.256","volume":"128","year":"1973","unstructured":"CARP, R.I., REPLICATION OF FACTOR IN SCRAPIE MATERIAL THAT CAUSES A DECREASE IN POLYMORPHONUCLEAR NEUTROPHILS, JOURNAL OF INFECTIOUS DISEASES 128: 256 (1973).","journal-title":"JOURNAL OF INFECTIOUS DISEASES"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0034-5288(18)34226-7","volume":"12","year":"1971","unstructured":"CLARKE, M.C., MULTIPLICATION OF SCRAPIE AGENT IN MOUSE SPLEEN, RESEARCH IN VETERINARY SCIENCE 12: 195 (1971).","journal-title":"RESEARCH IN VETERINARY SCIENCE"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/256732a0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0021-9975(74)90023-1","volume":"84","year":"1974","unstructured":"DICKINSON, A.G., MATERNAL AND LATERAL TRANSMISSION OF SCRAPIE IN SHEEP, JOURNAL OF COMPARATIVE PATHOLOGY 84: 19 (1974).","journal-title":"JOURNAL OF COMPARATIVE PATHOLOGY"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/248510a0","volume":"248","year":"1974","unstructured":"DICKINSON, A.G., DEPRESSION OF POLYMORPH COUNTS BY VARIOUS SCRAPIE AGENTS, NATURE 248: 510 (1974).","journal-title":"NATURE"},{"key":"e_1_2_1_8_1","first-page":"179","volume":"252","year":"1974","unstructured":"DICKINSON, A.G., SCRAPIE, NATURE 252: 179 (1974).","journal-title":"NATURE"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/226462a0"},{"key":"e_1_2_1_10_1","first-page":"254","volume":"5","year":"1973","unstructured":"GAJDUSEK, D.C., KURU AND CREUTZFELDT-JAKOB DISEASE - EXPERIMENTAL MODELS OF NONINFLAMMATORY DEGENERATIVE SLOW VIRUS DISEASE OF CENTRAL NERVOUS-SYSTEM, ANNALS OF CLINICAL RESEARCH 5: 254 (1973).","journal-title":"ANNALS OF CLINICAL RESEARCH"},{"key":"e_1_2_1_11_1","first-page":"84","volume":"35","year":"1972","unstructured":"GIBBS, C.J., JOURNAL OF CLINICAL PATHOLOGY 35 6: 84 (1972).","journal-title":"JOURNAL OF CLINICAL PATHOLOGY"},{"key":"e_1_2_1_12_1","unstructured":"Greares M. 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