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Out of 8000 trophic units present in a 12-day embryo, 2500 were contained in the eye. A subdissection of the eye showed its activity to be localized in a fraction containing the ciliary body and choroid coat, with a specific activity almost 20-fold higher than that of the whole embryo. This selective intraocular distribution at a time when survival or death of ciliary ganglionic neurons is decided in vivo suggests that this soluble factor may be involved in the normal development of the ciliary ganglion.<\/jats:p>","DOI":"10.1126\/science.451576","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T16:39:42Z","timestamp":1160066382000},"page":"1434-1436","source":"Crossref","is-referenced-by-count":352,"title":["Cholinergic Neuronotrophic Factors: Intraocular Distribution of Trophic Activity for Ciliary Neurons"],"prefix":"10.1126","volume":"204","author":[{"given":"R.","family":"Adler","sequence":"first","affiliation":[{"name":"Departments of Biology and Neuroscience, University of California at San Diego, La Jolla 92093"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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