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Thyroid function returned to normal from age 18 through 60 days in spite of continued iodide administration, strongly suggesting that resistance to the inhibitory effect of iodide on thyroid hormone synthesis is developed at approximately 18 days of age. This perinatal rat model can be used to study the mechanisms responsible for iodide-induced hypothyroidism and goiter in human newborns whose mothers received iodide-containing medications during pregnancy.<\/jats:p>","DOI":"10.1126\/science.451615","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T12:39:42Z","timestamp":1160051982000},"page":"502-503","source":"Crossref","is-referenced-by-count":97,"title":["Iodide-Induced Hypothyroidism: A Potential Hazard During Perinatal Life"],"prefix":"10.1126","volume":"205","author":[{"given":"Theodor","family":"Theodoropoulos","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, University of Massachusetts Medical School, Worcester 01605"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis E.","family":"Braverman","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, University of Massachusetts Medical School, Worcester 01605"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apostolos G.","family":"Vagenakis","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, University of Massachusetts Medical School, Worcester 01605"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/S0022-3476(76)80437-4","volume":"89","year":"1976","unstructured":"J PEDIATR 89: 692 (1976).","journal-title":"J PEDIATR"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1542\/peds.57.2.272","volume":"57","year":"1976","unstructured":"PEDIATRICS 57: 272 (1976).","journal-title":"PEDIATRICS"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1210\/jcem-32-4-515","volume":"32","year":"1971","unstructured":"BRAVERMAN, L.E., ENHANCED SUSCEPTIBILITY TO IODIDE MYXEDEMA IN PATIENTS WITH HASHIMOTOS DISEASE, JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 32: 515 (1971).","journal-title":"JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1172\/JCI104807","volume":"42","year":"1963","unstructured":"BRAVERMAN, L.E., CHANGES IN THYROIDAL FUNCTION DURING ADAPTATION TO LARGE DOSES OF IODIDE, JOURNAL OF CLINICAL INVESTIGATION 42: 1216 (1963).","journal-title":"JOURNAL OF CLINICAL INVESTIGATION"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1056\/NEJM196910092811504","volume":"281","year":"1969","unstructured":"BRAVERMAN, L.E., INDUCTION OF MYXEDEMA BY IODIDE IN PATIENTS EUTHYROID AFTER RADIOIODINE OR SURGICAL TREATMENT OF DIFFUSE TOXIC GOITER, NEW ENGLAND JOURNAL OF MEDICINE 281: 816 (1969).","journal-title":"NEW ENGLAND JOURNAL OF MEDICINE"},{"key":"e_1_2_1_6_1","first-page":"477","year":"1976","unstructured":"CLARK, O.H., THYROID RES: 477 (1976).","journal-title":"THYROID RES"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1210\/endo-97-5-1321","volume":"97","year":"1975","unstructured":"DUSSAULT, J.H., DEVELOPMENT OF HYPOTHALAMIC-PITUITARY-THYROID AXIS IN NEONATAL RAT, ENDOCRINOLOGY 97: 1321 (1975).","journal-title":"ENDOCRINOLOGY"},{"key":"e_1_2_1_8_1","first-page":"59","volume":"33","year":"1977","unstructured":"FISHER, D.A., RECENT PROGRESS IN HORMONE RESEARCH 33: 59 (1977).","journal-title":"RECENT PROGRESS IN HORMONE RESEARCH"},{"key":"e_1_2_1_9_1","first-page":"1590","volume":"13","year":"1964","unstructured":"FOLLIS, R.H., FURTHER OBSERVATIONS ON THYROIDITIS + COLLOID ACCUMULATION IN HYPERPLASTIC THYROID GLANDS OF HAMSTERS RECEIVING EXCESS IODINE, LABORATORY INVESTIGATION 13: 1590 (1964).","journal-title":"LABORATORY INVESTIGATION"},{"key":"e_1_2_1_10_1","first-page":"257","volume":"4","year":"1929","unstructured":"GRAY, S.H., AM J PATHOL 4: 257 (1929).","journal-title":"AM J PATHOL"},{"key":"e_1_2_1_11_1","first-page":"205","volume":"1","year":"1966","unstructured":"HALL, R, CLINICAL & EXPERIMENTAL IMMUNOLOGY 1: 205 (1966).","journal-title":"CLINICAL & EXPERIMENTAL IMMUNOLOGY"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1210\/endo-103-5-1662","volume":"103","year":"1978","unstructured":"HARRIS, ARC, ENDOCRINOLOGY 103: 1662 (1978).","journal-title":"ENDOCRINOLOGY"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1210\/endo-98-2-295","volume":"98","year":"1976","unstructured":"KIEFFER, J.D., PITUITARY-THYROID AXIS IN NEONATAL AND ADULT RATS - 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