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The results revealed that (i) HTLV-III is an exogenous human retrovirus, approximately 10 kilobases in length, that lacks nucleic acid sequences derived from normal human DNA; (ii) HTLV-III, unlike HTLV types I and II, shows substantial diversity in its genomic restriction enzyme cleavage pattern; (iii) HTLV-III persists in substantial amounts in cells as unintegrated linear DNA, an uncommon property that has been linked to the cytopathic effects of certain animal retroviruses; and (iv) HTLV-III viral DNA can be detected in low levels in fresh (primary) lymphoid tissue of a minority of patients with AIDS or ARC but appears not to be present in Kaposi's sarcoma tissue. These findings have important implications concerning the biological properties of HTLV-III and the pathophysiology of AIDS and Kaposi's sarcoma.<\/jats:p>","DOI":"10.1126\/science.6095449","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T15:41:59Z","timestamp":1160062919000},"page":"1165-1171","source":"Crossref","is-referenced-by-count":466,"title":["Molecular Characterization of Human T-Cell Leukemia (Lymphotropic) Virus Type III in the Acquired Immune Deficiency Syndrome"],"prefix":"10.1126","volume":"226","author":[{"given":"George M.","family":"Shaw","sequence":"first","affiliation":[{"name":"Laboratory of Tumor Cell Biology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice H.","family":"Hahn","sequence":"additional","affiliation":[{"name":"Laboratory of Tumor Cell Biology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh K.","family":"Arya","sequence":"additional","affiliation":[{"name":"Laboratory of Tumor Cell Biology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome E.","family":"Groopman","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Internal Medicine, New England Deaconess Hospital, Boston, Massachusetts 02255"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Gallo","sequence":"additional","affiliation":[{"name":"Laboratory of Tumor Cell Biology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flossie","family":"Wong-Staal","sequence":"additional","affiliation":[{"name":"Laboratory of Tumor Cell Biology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20205"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6089333"},{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6189183"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.52.070183.001505"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1146\/annurev.bi.47.070178.000343","volume":"47","year":"1978","unstructured":"BISHOP, J.M., RETROVIRUSES, ANNUAL REVIEW OF BIOCHEMISTRY 47: 35 (1978).","journal-title":"ANNUAL REVIEW OF BIOCHEMISTRY"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6328663"},{"key":"e_1_2_1_6_1","first-page":"6207","volume":"81","year":"1984","unstructured":"FRANCHINI, G, HUMAN T-CELL LEUKEMIA-VIRUS (HTLV-I) TRANSCRIPTS IN FRESH AND CULTURED-CELLS OF PATIENTS WITH ADULT T-CELL LEUKEMIA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 81: 6207 (1984).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES"},{"key":"e_1_2_1_7_1","first-page":"114","volume":"3","year":"1984","unstructured":"GALLO, R.C., CANCER SURVEYS 3: 114 (1984).","journal-title":"CANCER SURVEYS"},{"key":"e_1_2_1_8_1","unstructured":"GALLO R.C. 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