{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T22:18:48Z","timestamp":1771625928682,"version":"3.50.1"},"reference-count":38,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4430","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1980,2]]},"abstract":"<jats:p>\n            The neurotoxin 6-hydroxydopamine produced a permanent loss of endogenous norepinephrine and of\n            <jats:sup>3<\/jats:sup>\n            H-labeled norepinephrine uptake sites in the hippocampus within 5 days. These losses were initially accompanied by parallel decreases in tyrosine hydroxylase activity and synaptosomal norepinephrine synthesis. Within 21 days, however, hippocampal tyrosine hydroxylase activity and norepinephrine synthesis rate increased three- to fivefold. These data suggest a novel form of plasticity in brain-damaged animals characterized by an increase in the capacity for transmitter biosynthesis in residual neurons.\n          <\/jats:p>","DOI":"10.1126\/science.6101509","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T17:45:58Z","timestamp":1160070358000},"page":"537-540","source":"Crossref","is-referenced-by-count":83,"title":["Compensatory Increase in Tyrosine Hydroxylase Activity in Rat Brain After Intraventricular Injections of 6-Hydroxydopamine"],"prefix":"10.1126","volume":"207","author":[{"given":"Ann L.","family":"Acheson","sequence":"first","affiliation":[{"name":"Departments of Biological Sciences and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Zigmond","sequence":"additional","affiliation":[{"name":"Departments of Biological Sciences and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward M.","family":"Stricker","sequence":"additional","affiliation":[{"name":"Departments of Biological Sciences and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"142","volume":"10","year":"1979","unstructured":"ACHESON, A. L., TRANSACTIONS OF THE AMERICAN SOCIETY FOR NEUROCHEMISTRY 10: 142 (1979).","journal-title":"TRANSACTIONS OF THE AMERICAN SOCIETY FOR NEUROCHEMISTRY"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1111\/j.1476-5381.1970.tb10655.x","volume":"40","year":"1970","unstructured":"BELL, L.J., TIME COURSE OF EFFECTS OF 6-HYDROXYDOPAMINE ON CATECHOLAMINE-CONTAINING NEURONES IN RAT HYPOTHALAMUS AND STRIATUM, BRITISH JOURNAL OF PHARMACOLOGY 40: 790 (1970).","journal-title":"BRITISH JOURNAL OF PHARMACOLOGY"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1152\/physrev.1979.59.1.62","volume":"59","year":"1979","unstructured":"BJORKLUND, A, REGENERATION OF MONO-AMINERGIC AND CHOLINERGIC NEURONS IN THE MAMMALIAN CENTRAL NERVOUS-SYSTEM, PHYSIOLOGICAL REVIEWS 59: 62 (1979).","journal-title":"PHYSIOLOGICAL REVIEWS"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/0006-8993(75)90219-X","volume":"95","year":"1975","unstructured":"BLACK, I.B., INCREASED TYROSINE-HYDROXYLASE ACTIVITY IN FRONTAL CORTEX AND CEREBELLUM AFTER RESERPINE, BRAIN RESEARCH 95: 170 (1975).","journal-title":"BRAIN RESEARCH"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.166.3910.1284"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1476-5381.1971.tb07089.x","volume":"42","year":"1971","unstructured":"BREESE, G.R., DEPLETION OF BRAIN NORADRENALINE AND DOPAMINE BY 6-HYDROXYDOPAMINE, BRITISH JOURNAL OF PHARMACOLOGY 42: 88 (1971).","journal-title":"BRITISH JOURNAL OF PHARMACOLOGY"},{"key":"e_1_2_1_7_1","first-page":"137","volume":"1","year":"1975","unstructured":"Breese, G. R., Handbook of Psychopharmacology 1: 137 (1975).","journal-title":"Handbook of Psychopharmacology"},{"key":"e_1_2_1_8_1","first-page":"413","volume":"174","year":"1970","unstructured":"BREESE, G.R., EFFECT OF 6-HYDROXYDOPAMINE ON BRAIN NOREPINEPHRINE AND DOPAMINE - EVIDENCE FOR SELECTIVE DEGENERATION OF CATECHOLAMINE NEURONS, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 174: 413 (1970).","journal-title":"JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS"},{"key":"e_1_2_1_9_1","first-page":"417","volume":"178","year":"1971","unstructured":"BRINIJOIN, S, J PHARMACOL EXP THER 178: 417 (1971).","journal-title":"J PHARMACOL EXP THER"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/0006-8993(72)90676-2","volume":"37","year":"1972","unstructured":"DEXAUIES, L, BRAIN RES 37: 310 (1972).","journal-title":"BRAIN RES"},{"key":"e_1_2_1_11_1","first-page":"5","year":"1975","unstructured":"EDVINSSON, L, ACTA PHYSIOLOGICA SCANDINAVICA 427: 5 (1975).","journal-title":"ACTA PHYSIOLOGICA SCANDINAVICA"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0006-8993(73)90493-9","volume":"55","year":"1973","unstructured":"FIBIGER, H.C., FEEDING AND DRINKING DEFICITS AFTER 6-HYDROXYDOPAMINE ADMINISTRATION IN RAT - SIMILARITIES TO LATERAL HYPOTHALAMIC SYNDROME, BRAIN RESEARCH 55: 135 (1973).","journal-title":"BRAIN RESEARCH"},{"key":"e_1_2_1_13_1","first-page":"79","volume":"96","year":"1962","unstructured":"GRAY, E.G., ISOLATION OF NERVE ENDINGS FROM BRAIN - AN ELECTRON-MICROSCOPIC STUDY OF CELL FRAGMENTS DERIVED BY HOMOGENIZATION AND CENTRIFUGATION, JOURNAL OF ANATOMY 96: 79 (1962).","journal-title":"JOURNAL OF ANATOMY"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/0006-8993(70)90121-6","volume":"24","year":"1970","unstructured":"IVERSEN, L.L., BRAIN RES 24: 364 (1970).","journal-title":"BRAIN RES"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0006-8993(79)90108-2","volume":"170","year":"1979","unstructured":"KAPATOS, G, REGULATION OF DOPAMINE SYNTHESIS IN STRIATAL SYNAPTOSOMES DURING DEPOLARIZATION, BRAIN RESEARCH 170: 299 (1979).","journal-title":"BRAIN RESEARCH"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1111\/j.1471-4159.1977.tb10675.x","volume":"28","year":"1977","unstructured":"KAPATOS, G, DOPAMINE BIOSYNTHESIS FROM L-TYROSINE AND L-PHENYLALANINE IN RAT-BRAIN SYNAPTOSOMES - PREFERENTIAL USE OF NEWLY ACCUMULATED PRECURSORS, JOURNAL OF NEUROCHEMISTRY 28: 1109 (1977).","journal-title":"JOURNAL OF NEUROCHEMISTRY"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1111\/j.1476-5381.1970.tb10659.x","volume":"40","year":"1970","unstructured":"LAVERTY, R, EFFECTS OF INTRAVENTRICULAR 2,4,5-TRIHYDROXYPHENYL-ETHYLAMINE (6-HYDROXYDOPAMINE) ON RAT BEHAVIOUR AND BRAIN CATECHOLAMINE METABOLISM, BRITISH JOURNAL OF PHARMACOLOGY 40: 836 (1970).","journal-title":"BRITISH JOURNAL OF PHARMACOLOGY"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/0014-4886(77)90096-6","volume":"57","year":"1977","unstructured":"LOY, R, ANOMALOUS INNERVATION OF HIPPOCAMPAL FORMATION BY PERIPHERAL SYMPATHETIC AXONS FOLLOWING MECHANICAL INJURY, EXPERIMENTAL NEUROLOGY 57: 645 (1977).","journal-title":"EXPERIMENTAL NEUROLOGY"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1037\/h0037223","volume":"87","year":"1974","unstructured":"MARSHALL, J.F., NIGROSTRIATAL BUNDLE DAMAGE AND LATERAL HYPOTHALAMIC SYNDROME, JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY 87: 808 (1974).","journal-title":"JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.163.3866.468"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0024-3205(67)90157-9","volume":"6","year":"1967","unstructured":"NOBEL, E.P., LIFE SCI 6: 281 (1967).","journal-title":"LIFE SCI"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0006-8993(73)90139-X","volume":"57","year":"1973","unstructured":"REIS, D.J., DYNAMIC CHANGES IN BRAIN DOPAMINE-BETA-HYDROXYLASE ACTIVITY DURING ANTEROGRADE AND RETROGRADE REACTIONS TO INJURY OF CENTRAL NORADRENERGIC AXONS, BRAIN RESEARCH 57: 307 (1973).","journal-title":"BRAIN RESEARCH"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/0006-8993(74)90956-1","volume":"81","year":"1974","unstructured":"REIS, D.J., RESERPINE SELECTIVELY INCREASES TYROSINE-HYDROXYLASE AND DOPAMINE-BETA-HYDROXYLASE ENZYME PROTEIN IN CENTRAL NORADRENERGIC NEURONS, BRAIN RESEARCH 81: 380 (1974).","journal-title":"BRAIN RESEARCH"},{"key":"e_1_2_1_25_1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0006-8993(78)90158-0","volume":"144","year":"1978","unstructured":"REIS, D.J., REVERSIBLE CHANGES IN ACTIVITIES AND AMOUNTS OF TYROSINE-HYDROXYLASE IN DOPAMINE NEURONS OF SUBSTANTIA NIGRA IN RESPONSE TO AXONAL INJURY AS STUDIED BY IMMUNOCHEMICAL AND IMMUNOCYTOCHEMICAL METHODS, BRAIN RESEARCH 144: 325 (1978).","journal-title":"BRAIN RESEARCH"},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0006-8993(75)90527-2","volume":"92","year":"1975","unstructured":"ROSS, R.A., REVERSIBLE CHANGES IN ACCUMULATION AND ACTIVITIES OF TYROSINE-HYDROXYLASE AND DOPAMINE-BETA-HYDROXYLASE IN NEURONS OF NUCLEUS LOCUS COERULEUS DURING RETROGRADE REACTION, BRAIN RESEARCH 92: 57 (1975).","journal-title":"BRAIN RESEARCH"},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/0024-3205(78)90345-4","volume":"23","year":"1978","unstructured":"SALLER, C.F., RADIOENZYMATIC ASSAY FOR CATECHOLAMINES AND DIHYDROXYPHENYLACETIC ACID, LIFE SCIENCES 23: 1117 (1978).","journal-title":"LIFE SCIENCES"},{"key":"e_1_2_1_28_1","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/0006-8993(75)90674-5","volume":"88","year":"1975","unstructured":"SORIMACHI, M, SUSCEPTIBILITY OF CATECHOLAMINERGIC CELL BODIES TO 6-HYDROXYDOPAMINE - ENZYMIC EVIDENCE, BRAIN RESEARCH 88: 572 (1975).","journal-title":"BRAIN RESEARCH"},{"key":"e_1_2_1_29_1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0304-3940(78)90171-4","volume":"7","year":"1978","unstructured":"STENEVI, U, GROWTH OF VASCULAR SYMPATHETIC AXONS INTO HIPPOCAMPUS AFTER LESIONS OF SEPTO-HIPPOCAMPAL PATHWAY - PITFALL IN BRAIN LESION STUDIES, NEUROSCIENCE LETTERS 7: 219 (1978).","journal-title":"NEUROSCIENCE LETTERS"},{"key":"e_1_2_1_30_1","first-page":"121","volume":"6","year":"1976","unstructured":"Stricker, E. M., Progress in Psychobiology and Physiological Psychology 6: 121 (1976).","journal-title":"Progress in Psychobiology and Physiological Psychology"},{"key":"e_1_2_1_31_1","first-page":"249","volume":"169","year":"1969","unstructured":"THOENEN, H, TRANS-SYNAPTIC INDUCTION OF ADRENAL TYROSINE HYDROXYLASE, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 169: 249 (1969).","journal-title":"JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS"},{"key":"e_1_2_1_32_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF02146956","volume":"24","year":"1968","unstructured":"TRANZER, J.P., AN ELECTRON MICROSCOPIC STUDY OF SELECTIVE ACUTE DEGENERATION OF SYMPATHETIC NERVE TERMINALS AFTER ADMINISTRATION OF 6-HYDROXYDOPAMINE, EXPERIENTIA 24: 155 (1968).","journal-title":"EXPERIENTIA"},{"key":"e_1_2_1_33_1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1471-4159.1970.tb02210.x","volume":"17","year":"1970","unstructured":"URETSKY, N.J., EFFECTS OF 6-HYDROXYDOPAMINE ON CATECHOLAMINE CONTAINING NEURONES IN RAT BRAIN, JOURNAL OF NEUROCHEMISTRY 17: 269 (1970).","journal-title":"JOURNAL OF NEUROCHEMISTRY"},{"key":"e_1_2_1_34_1","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/0003-2697(71)90291-0","volume":"43","year":"1971","unstructured":"WAYMIRE, J.C., ASSAY OF TYROSINE HYDROXYLASE BY COUPLED DECARBOXYLATION OF DOPA FORMED FROM 1-C-14-L-TYROSINE, ANALYTICAL BIOCHEMISTRY 43: 588 (1971).","journal-title":"ANALYTICAL BIOCHEMISTRY"},{"key":"e_1_2_1_35_1","first-page":"20","volume":"179","year":"1971","unstructured":"ZIGMOND, M.J., EFFECT OF LATERAL HYPOTHALAMIC LESIONS ON UPTAKE OF NOREPINEPHRINE BY BRAIN HOMOGENATES, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 179: 20 (1971).","journal-title":"JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.177.4055.1211"},{"key":"e_1_2_1_37_1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0006-8993(74)90267-4","volume":"70","year":"1974","unstructured":"ZIGMOND, R.E., INCREASED TYROSINE-HYDROXYLASE ACTIVITY IN LOCUS COERULEUS OF RAT-BRAIN STEM AFTER RESERPINE TREATMENT AND COLD STRESS, BRAIN RESEARCH 70: 547 (1974).","journal-title":"BRAIN RESEARCH"},{"key":"e_1_2_1_38_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1471-4159.1979.tb04505.x","volume":"32","year":"1979","unstructured":"ZIGMOND, R.E., TYROSINE-HYDROXYLASE ACTIVITY IN NORADRENERGIC NEURONS OF THE LOCUS COERULEUS AFTER RESERPINE ADMINISTRATION - SEQUENTIAL INCREASE IN CELL BODIES AND NERVE-TERMINALS, JOURNAL OF NEUROCHEMISTRY 32: 23 (1979).","journal-title":"JOURNAL OF NEUROCHEMISTRY"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.6101509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T15:25:58Z","timestamp":1705245958000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.6101509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,2]]},"references-count":38,"journal-issue":{"issue":"4430","published-print":{"date-parts":[[1980,2]]}},"alternative-id":["10.1126\/science.6101509"],"URL":"https:\/\/doi.org\/10.1126\/science.6101509","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,2]]}}}