{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:02:31Z","timestamp":1762160551359},"reference-count":21,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4472","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1980,11,21]]},"abstract":"<jats:p>\n            A continuous hybrid cell line was derived that secretes monoclonal antibody capable of inhibiting the biological activity of mouse \u03b2-nerve growth factor (\u03b2-NGF). Results obtained with monovalent fragments indicate that the monoclonal antibody inhibits activity by interfering with the direct interaction between \u03b2-NGF and the cell membrane receptor rather than by precipitating the dimeric form of \u03b2-NGF. This monoclonal antibody binds to an antigenic determinant common to mouse \u03b2-NGF, snake venom (\n            <jats:italic>Naja naja<\/jats:italic>\n            ) \u03b2-NGF, and human \u03b2-NGF. These antibodies should provide specific molecular probes for a variety of studies of nerve growth factor including its tissue distribution and mechanism of action.\n          <\/jats:p>","DOI":"10.1126\/science.6159686","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T17:45:58Z","timestamp":1160070358000},"page":"910-912","source":"Crossref","is-referenced-by-count":32,"title":["Inhibition of Biological Activity of Mouse \u03b2-Nerve Growth Factor by Monoclonal Antibody"],"prefix":"10.1126","volume":"210","author":[{"given":"Stephen L.","family":"Warren","sequence":"first","affiliation":[{"name":"Departments of Microbiology and Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Fanger","sequence":"additional","affiliation":[{"name":"Departments of Microbiology and Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth E.","family":"Neet","sequence":"additional","affiliation":[{"name":"Departments of Microbiology and Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0304-4165(76)90368-8","volume":"437","year":"1976","unstructured":"BAILEY, G.S., IMMUNOLOGICAL PROPERTIES OF NERVE GROWTH-FACTORS, BIOCHIMICA ET BIOPHYSICA ACTA 437: 259 (1976).","journal-title":"BIOCHIMICA ET BIOPHYSICA ACTA"},{"key":"e_1_2_1_2_1","first-page":"2519","volume":"70","year":"1973","unstructured":"BANERJEE, S.P., BINDING OF NERVE GROWTH-FACTOR RECEPTOR IN SYMPATHETIC-GANGLIA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 70: 2519 (1973).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4049\/jimmunol.109.1.129","volume":"109","year":"1972","unstructured":"ENGVALL, E, ENZYME-LINKED IMMUNOSORBENT ASSAY, ELISA .3. 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