{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:34:44Z","timestamp":1757705684913},"reference-count":15,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"1605","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1925,10,2]]},"abstract":"<jats:p>When a small amount of blood serum is dropped into the nose of a guinea pig the serum is absorbed by the mucous membrane and, after a definite period of incubation, the animal can be shown to have become profoundly changed.<\/jats:p>\n          <jats:p>Depending upon the number of instillations, the interval between them and, especially, the quantity of serum instilled, the animal becomes either highly hypersensitive or strongly resistant to a toxic injection given by the vein. This resistance withstands a considerable series of increasing toxic injections and is strengthened with lapse of time,\u2014contrary to the state of tolerance produced by traumatic methods.<\/jats:p>\n          <jats:p>\n            It is inferred that the absorption of foreign protein by the nose causes the formation of two different antibodies. One of these is\n            <jats:italic>allergic<\/jats:italic>\n            and excites to anaphylaxis; the other is\n            <jats:italic>protective<\/jats:italic>\n            and leads to true immunity. The relative amount of either antibody can be regulated by modifying the amount of serum instilled.\n          <\/jats:p>\n          <jats:p>Added to a state of general allergy it is easy to produce, in the guinea pig, a special sensitization of the respiratory apparatus which leads, under appropriate stimulation, to attacks resembling those of bronchial asthma in man.<\/jats:p>\n          <jats:p>No conclusion can be drawn at present concerning the nature or mode of action of the protective or immunizing antibody; but the indications are that its relations to the circulation and to tissue fixation resemble those which have been developed by other investigators in regard to the anaphylactic antibody.<\/jats:p>\n          <jats:p>Evidence has been submitted that the living epithelium mediates between foreign protein and the organism in a way to favor specifically the elaboration of true immunity.<\/jats:p>","DOI":"10.1126\/science.62.1605.293","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T01:26:05Z","timestamp":1160011565000},"page":"293-299","source":"Crossref","is-referenced-by-count":7,"title":["The R\u00f4le of Epithelium in Experimental Immunization"],"prefix":"10.1126","volume":"62","author":[{"given":"Henry","family":"Sewall","sequence":"first","affiliation":[{"name":"Denver, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"361","volume":"34","year":"1920","unstructured":"Besredka, A.,Annales de l'Institut Pasteur 34: 361 (1920).","journal-title":"Annales de l'Institut Pasteur"},{"key":"e_1_2_1_2_1","first-page":"51","volume":"34","year":"1920","unstructured":"Besredka, A.,Annales de l'Institut Pasteur 34: 51 (1920).","journal-title":"Annales de l'Institut Pasteur"},{"key":"e_1_2_1_3_1","first-page":"496","year":"1922","unstructured":"Besredka, A.,Paris Medical: 496 (2 12 1922).","journal-title":"Paris Medical"},{"key":"e_1_2_1_4_1","first-page":"301","volume":"33","year":"1919","unstructured":"Besredka, A.,Annales de l'Institut Pasteur 33: 301 (1919).","journal-title":"Annales de l'Institut Pasteur"},{"key":"e_1_2_1_5_1","first-page":"205","volume":"31","year":"1914","unstructured":"GURD, F.B., Studies upon anaphylaxis and its relationship to immunity. Study I. The so-called incubation period in transferred anaphylaxis., JOURNAL OF MEDICAL RESEARCH 31: 205 (1914).","journal-title":"JOURNAL OF MEDICAL RESEARCH"},{"key":"e_1_2_1_6_1","unstructured":"Gurd F. B. Infection Immunity and Inflammation (1925)."},{"key":"e_1_2_1_7_1","first-page":"1482","volume":"72","year":"1915","unstructured":"Heidenhain, L., Munchener Medizinische Wochenschrift 72: 1482 (1915).","journal-title":"Munchener Medizinische Wochenschrift"},{"key":"e_1_2_1_8_1","first-page":"1302","year":"1924","unstructured":"SANARELLI, G, COMPTES RENDUS SOC B: 1302 (1924).","journal-title":"COMPTES RENDUS SOC B"},{"key":"e_1_2_1_9_1","first-page":"236","volume":"5","year":"1921","unstructured":"Sewall, H., American Review of Tuberculosis 5: 236 (1921).","journal-title":"American Review of Tuberculosis"},{"key":"e_1_2_1_10_1","first-page":"874","volume":"2","year":"1917","unstructured":"SEWALL, H, Experimental asthma in the guinea pig, JOURNAL OF LABORATORY AND CLINICAL MEDICINE 2: 874 (1917).","journal-title":"JOURNAL OF LABORATORY AND CLINICAL MEDICINE"},{"key":"e_1_2_1_11_1","first-page":"856","volume":"13","year":"1914","unstructured":"SEWALL, H, Some relations of the brain and of the olfactory apparatus to the processes of immunity, ARCHIVES OF INTERNAL MEDICINE 13: 856 (1914).","journal-title":"ARCHIVES OF INTERNAL MEDICINE"},{"key":"e_1_2_1_12_1","first-page":"95","volume":"67","year":"1916","unstructured":"Sewall, H., Journal of the American Medical Association 67: 95 (1916).","journal-title":"Journal of the American Medical Association"},{"key":"e_1_2_1_13_1","first-page":"605","volume":"16","year":"1915","unstructured":"SEWALL, H, Studies of the relations of the hypersusceptibility and insusceptibility induced in guinea-pigs by the instillation of horse serum into the nose, ARCHIVES OF INTERNAL MEDICINE 16: 605 (1915).","journal-title":"ARCHIVES OF INTERNAL MEDICINE"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1084\/jem.24.1.69","volume":"24","year":"1916","unstructured":"SEWALL, H, The conditions and characters of the immunity produced in the guinea pig by instillation of horse serum into the nose., JOURNAL OF EXPERIMENTAL MEDICINE 24: 69 (1916).","journal-title":"JOURNAL OF EXPERIMENTAL MEDICINE"},{"key":"e_1_2_1_15_1","unstructured":"Vaughan V. C. Protein Split Products (1913)."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.62.1605.293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T15:32:49Z","timestamp":1705246369000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.62.1605.293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1925,10,2]]},"references-count":15,"journal-issue":{"issue":"1605","published-print":{"date-parts":[[1925,10,2]]}},"alternative-id":["10.1126\/science.62.1605.293"],"URL":"https:\/\/doi.org\/10.1126\/science.62.1605.293","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1925,10,2]]}}}