{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:39:25Z","timestamp":1791297565166,"version":"4.1.0"},"reference-count":21,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4664","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1984,8,24]]},"abstract":"<jats:p>\n            Infectious retroviruses have been detected in 22 of 45 randomly selected patients with acquired immune deficiency syndrome (AIDS) and in other individuals from San Francisco. The AIDS-associated retroviruses (ARV) studied in detail had a type D morphology, Mg\n            <jats:sup>2+<\/jats:sup>\n            -dependent reverse transcriptase, and cytopathic effects on lymphocytes. The viruses can be propagated in an established adult human T cell line, HUT-78. They cross-react with antiserum to the lymphadenopathy-associated retrovirus isolated from AIDS patients in France. Antibodies to ARV were found in all 86 AIDS patients and in a high percentage of 88 other homosexual men in San Francisco. This observation indicates the widespread presence of these lymphocytopathic retroviruses and their close association with AIDS.\n          <\/jats:p>","DOI":"10.1126\/science.6206563","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T19:41:59Z","timestamp":1160077319000},"page":"840-842","source":"Crossref","is-referenced-by-count":1021,"title":["Isolation of Lymphocytopathic Retroviruses from San Francisco Patients with AIDS"],"prefix":"10.1126","volume":"225","author":[{"given":"Jay A.","family":"Levy","sequence":"first","affiliation":[{"name":"Cancer Research Institute, Department of Medicine, University of California School of Medicine, San Francisco 94143"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony D.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Cancer Research Institute, Department of Medicine, University of California School of Medicine, San Francisco 94143"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Kramer","sequence":"additional","affiliation":[{"name":"Cancer Research Institute, Department of Medicine, University of California School of Medicine, San Francisco 94143"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill A.","family":"Landis","sequence":"additional","affiliation":[{"name":"Cancer Research Institute, Department of Medicine, University of California School of Medicine, San Francisco 94143"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joni M.","family":"Shimabukuro","sequence":"additional","affiliation":[{"name":"Cancer Research Institute, Department of Medicine, University of California School of Medicine, San Francisco 94143"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyndon S.","family":"Oshiro","sequence":"additional","affiliation":[{"name":"Viral and Rickettsial Disease Laboratory, California Department of Health Services, Berkeley 94704"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.7326\/0003-4819-100-6-801","volume":"100","year":"1984","unstructured":"ABRAMS, D.I., PERSISTENT DIFFUSE LYMPHADENOPATHY IN HOMOSEXUAL MEN - ENDPOINT OR PRODROME, ANNALS OF INTERNAL MEDICINE 100: 801 (1984).","journal-title":"ANNALS OF INTERNAL MEDICINE"},{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6189183"},{"key":"e_1_2_1_3_1","first-page":"51","volume":"21","year":"1968","unstructured":"BOYUM, A, A ONE-STAGE PROCEDURE FOR ISOLATION OF GRANULOCYTES AND LYMPHOCYTES FROM HUMAN BLOOD - GENERAL SEDIMENTATION PROPERTIES OF WHITE BLOOD CELLS IN A 1 G GRAVITY FIELD, SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION 21: 51 (1968).","journal-title":"SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198402233100804"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1093\/infdis\/143.2.188","volume":"143","year":"1981","unstructured":"DREW, W.L., PREVALENCE OF CYTOMEGALOVIRUS-INFECTION IN HOMOSEXUAL MEN, JOURNAL OF INFECTIOUS DISEASES 143: 188 (1981).","journal-title":"JOURNAL OF INFECTIOUS DISEASES"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6601823"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6200936"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1182\/blood.V55.3.409.409","volume":"55","year":"1980","unstructured":"GAZDAR, A.F., MITOGEN REQUIREMENTS FOR THE INVITRO-PROPAGATION OF CUTANEOUS T-CELL LYMPHOMAS, BLOOD 55: 409 (1980).","journal-title":"BLOOD"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6601822"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.10.6476"},{"key":"e_1_2_1_11_1","first-page":"145","volume":"99","year":"1983","unstructured":"JAFFE, H.W., NATIONAL CASE-CONTROL STUDY OF KAPOSIS SARCOMA AND PNEUMOCYSTIS-CARINII PNEUMONIA IN HOMOSEXUAL MEN .1. EPIDEMIOLOGIC RESULTS, ANNALS OF INTERNAL MEDICINE 99: 145 (1983).","journal-title":"ANNALS OF INTERNAL MEDICINE"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/infdis\/148.2.339","volume":"148","year":"1983","unstructured":"JAFFE, H.W., ACQUIRED IMMUNE-DEFICIENCY SYNDROME IN THE UNITED-STATES - THE 1ST 1,000 CASES, JOURNAL OF INFECTIOUS DISEASES 148: 339 (1983).","journal-title":"JOURNAL OF INFECTIOUS DISEASES"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.38.3.906-915.1981"},{"key":"e_1_2_1_14_1","unstructured":"LEVY J.A. unpublished data."},{"key":"e_1_2_1_15_1","unstructured":"Montagnier L. 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