{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:57:10Z","timestamp":1776920230269,"version":"3.51.2"},"reference-count":18,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4649","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1984,5,11]]},"abstract":"<jats:p>\n            Long-term exposure of C3H mice to ultraviolet radiation resulted in the formation of suppressor T cells that recognize ultraviolet radiation-induced regressor skin cancers as a class before the appearance of overt tumors. Administration of monoclonal antibodies to the product of the I-J\n            <jats:sup>k<\/jats:sup>\n            subregion of the major histocompatibility complex or low doses of cyclophosphamide in vivo inhibited the development or activity of these cells. This activity of the monoclonal antibody was eliminated by adsorption on B10.BR (I-J\n            <jats:sup>k<\/jats:sup>\n            ) but not B10.D2 (I-J\n            <jats:sup>d<\/jats:sup>\n            ) splenocytes. These findings provide evidence that elements expressing the I-J determinant are important in regulating the host response prior to the overt development of ultraviolet radiation-induced skin cancers and suggest novel therapeutic approaches to malignancies or other diseases involving suppressor T cells in their pathogenesis.\n          <\/jats:p>","DOI":"10.1126\/science.6231725","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T19:41:59Z","timestamp":1160077319000},"page":"615-617","source":"Crossref","is-referenced-by-count":17,"title":["Immunologic Inhibition of Ultraviolet Radiation-Induced Tumor Suppressor Cell Activity"],"prefix":"10.1126","volume":"224","author":[{"given":"Richard D.","family":"Granstein","sequence":"first","affiliation":[{"name":"Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston 02114"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Parrish","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston 02114"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"McAuliffe","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston 02114"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl","family":"Waltenbaugh","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Northwestern University Medical School, Chicago, Illinois 60611"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark I","family":"Greene","sequence":"additional","affiliation":[{"name":"Department of Pathology, Harvard Medical School, Boston 02114"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"628","DOI":"10.4049\/jimmunol.131.2.628","volume":"131","year":"1983","unstructured":"BAXEVANIS, C.N., THE NATURE OF THE INTERACTION BETWEEN SUPPRESSOR AND HELPER T-CELLS IN THE RESPONSE TO LDHB, JOURNAL OF IMMUNOLOGY 131: 628 (1983).","journal-title":"JOURNAL OF IMMUNOLOGY"},{"key":"e_1_2_1_2_1","first-page":"99","year":"1981","unstructured":"DREBIN, J.A., IMMUNOCHEMOTHERAPY: 99 (1981).","journal-title":"IMMUNOCHEMOTHERAPY"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"506","DOI":"10.4049\/jimmunol.130.1.506","volume":"130","year":"1983","unstructured":"DREBIN, J.A., INHIBITION OF TUMOR-GROWTH BY MONOCLONAL ANTI-I-J ANTIBODIES, JOURNAL OF IMMUNOLOGY 130: 506 (1983).","journal-title":"JOURNAL OF IMMUNOLOGY"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1084\/jem.154.4.1033","volume":"154","year":"1981","unstructured":"DYE, E.S., T-CELL-MEDIATED IMMUNOSUPPRESSION AS AN OBSTACLE TO ADOPTIVE IMMUNOTHERAPY OF THE P-815 MASTOCYTOMA AND ITS METASTASES, JOURNAL OF EXPERIMENTAL MEDICINE 154: 1033 (1981).","journal-title":"JOURNAL OF EXPERIMENTAL MEDICINE"},{"key":"e_1_2_1_5_1","first-page":"1688","volume":"74","year":"1977","unstructured":"FISHER, M.S., SYSTEMIC ALTERATION INDUCED IN MICE BY UV LIGHT IRRADIATION AND ITS RELATIONSHIP TO UV CARCINOGENESIS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 74: 1688 (1977).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6210958"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.4049\/jimmunol.132.2.563","volume":"132","year":"1984","unstructured":"GRANSTEIN, R.D., EPIDERMAL ANTIGEN-PRESENTING CELLS IN ACTIVATION OF SUPPRESSION - 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