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The discovery of this specific morphine receptor ligand substantiates the hypothesis of multiple opiate receptors. The ligand, which may be of physiological significance since a very similar, or identical, activity can be detected in enzymatic digests of \u03b2-casein, may prove useful for further investigation of the functions of opiate receptor subtypes.\n          <\/jats:p>","DOI":"10.1126\/science.6259732","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T17:45:58Z","timestamp":1160070358000},"page":"75-77","source":"Crossref","is-referenced-by-count":297,"title":["Morphiceptin (NH\n            <sub>4<\/sub>\n            -Tyr-Pro-Phe-Pro-COHN\n            <sub>2<\/sub>\n            ): a Potent and Specific Agonist for Morphine (\u03bc) Receptors"],"prefix":"10.1126","volume":"212","author":[{"given":"Kwen-Jen","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, Wellcome Research Laboratories, Research Triangle Park, North Carolina 27709"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Lillian","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Wellcome Research Laboratories, Research Triangle Park, North Carolina 27709"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Hazum","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Wellcome Research Laboratories, Research Triangle Park, North Carolina 27709"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Cuatrecasas","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Wellcome Research Laboratories, Research Triangle Park, North Carolina 27709"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaw-Kang","family":"Chang","sequence":"additional","affiliation":[{"name":"Peninsula Laboratories, San Carlos, California 94070"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"1713","volume":"75","year":"1978","unstructured":"BLUME, A.J., INTERACTION OF LIGANDS WITH OPIATE RECEPTORS OF BRAIN MEMBRANES - REGULATION BY IONS AND NUCLEOTIDES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 75: 1713 (1978).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/BF00507118","volume":"306","year":"1979","unstructured":"BRANTL, V, MATERIAL WITH OPIOID ACTIVITY IN BOVINE-MILK AND MILK-PRODUCTS, NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 306: 301 (1979).","journal-title":"NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)30115-1"},{"key":"e_1_2_1_4_1","first-page":"1","volume":"20","year":"1981","unstructured":"Chang, K.-J., Molecular Pharmacology 20: 1 (1981).","journal-title":"Molecular Pharmacology"},{"key":"e_1_2_1_5_1","first-page":"91","volume":"16","year":"1979","unstructured":"CHANG, K.J., MULTIPLE OPIATE RECEPTORS - DIFFERENT REGIONAL DISTRIBUTION IN THE BRAIN AND DIFFERENTIAL BINDING OF OPIATES AND OPIOID PEPTIDES, MOLECULAR PHARMACOLOGY 16: 91 (1979).","journal-title":"MOLECULAR PHARMACOLOGY"},{"key":"e_1_2_1_6_1","first-page":"4469","volume":"77","year":"1980","unstructured":"Chang, K. 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