{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T22:13:24Z","timestamp":1726438404834},"reference-count":44,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4546","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1982,5,7]]},"abstract":"<jats:p>The activity of angiotensin-converting enzyme is significantly higher in the intermediate and posterior pituitary lobes of Brattleboro rats than in Long-Evans control rats. The high activity level was reversed by vasopressin treatment. Conversely, angiotensin-converting enzyme activity was significantly lower in the anterior pituitary of Brattleboro rats than in Long-Evans rats, and this activity level was not affected by vasopressin. These findings suggest an inverse relation between vasopressin and angiotensin systems in the posterior and intermediate lobes of the pituitary gland.<\/jats:p>","DOI":"10.1126\/science.6280284","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T18:30:32Z","timestamp":1160073032000},"page":"646-647","source":"Crossref","is-referenced-by-count":14,"title":["High Angiotensin-Converting Enzyme Activity in the Neurohypophysis of Brattleboro Rats"],"prefix":"10.1126","volume":"216","author":[{"given":"C.","family":"Chevillard","sequence":"first","affiliation":[{"name":"Section on Pharmacology, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Saavedra","sequence":"additional","affiliation":[{"name":"Section on Pharmacology, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1016\/0006-2952(79)90054-6","volume":"28","year":"1979","unstructured":"ARREGUI, A, BETA-LIPOTROPIN POTENTLY INHIBITS A PURIFIED ANGIOTENSIN CONVERTING ENZYME FROM HUMAN-BRAIN, BIOCHEMICAL PHARMACOLOGY 28: 2693 (1979).","journal-title":"BIOCHEMICAL PHARMACOLOGY"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/0016-6480(75)90169-0","volume":"26","year":"1975","unstructured":"BALMENT, R.J., EFFECTS OF VASOPRESSIN ON PITUITARY OXYTOCIN CONTENT AND PLASMA-RENIN ACTIVITY IN RATS WITH HYPOTHALAMIC DIABETES-INSIPIDUS (BRATTLEBORO STRAIN), GENERAL AND COMPARATIVE ENDOCRINOLOGY 26: 468 (1975).","journal-title":"GENERAL AND COMPARATIVE ENDOCRINOLOGY"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1152\/ajplegacy.1970.218.6.1555","volume":"218","year":"1970","unstructured":"BONJOUR, J.P., STIMULATION OF ADH RELEASE BY RENIN-ANGIOTENSIN SYSTEM, AMERICAN JOURNAL OF PHYSIOLOGY 218: 1555 (1970).","journal-title":"AMERICAN JOURNAL OF PHYSIOLOGY"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1677\/joe.0.0720187","volume":"72","year":"1977","unstructured":"BUCKINGHAM, J.C., USE OF CORTICOTROPIN PRODUCTION BY ADENOHYPOPHYSEAL TISSUE INVITRO FOR DETECTION AND ESTIMATION OF POTENTIAL CORTICOTROPIN RELEASING FACTORS, JOURNAL OF ENDOCRINOLOGY 72: 187 (1977).","journal-title":"JOURNAL OF ENDOCRINOLOGY"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1113\/jphysiol.1980.sp013371","volume":"305","year":"1980","unstructured":"BUCKINGHAM, J.C., HYPOTHALAMO-PITUITARY-ADRENOCORTICAL FUNCTION IN RATS WITH INHERITED DIABETES-INSIPIDUS, JOURNAL OF PHYSIOLOGY-LONDON 305: 397 (1980).","journal-title":"JOURNAL OF PHYSIOLOGY-LONDON"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/cvr\/1.1.67","volume":"1","year":"1967","unstructured":"BUNAG, R.D., CARDIOVASC RES 1: 67 (1967).","journal-title":"CARDIOVASC RES"},{"key":"e_1_2_1_7_1","first-page":"233","year":"1977","unstructured":"Changaris, D. G., Central Actions of Angiotensin and Related Hormones: 233 (1977).","journal-title":"Central Actions of Angiotensin and Related Hormones"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF01466762","volume":"53","year":"1975","unstructured":"EHLRICH, E, KLINISCHE WOCHENSCHRIFT 53: 177 (1975).","journal-title":"KLINISCHE WOCHENSCHRIFT"},{"key":"e_1_2_1_9_1","first-page":"165","volume":"210","year":"1980","unstructured":"FITZSIMONS, J. T., ANGIOTENSIN AND OTHER PEPTIDES IN THE CONTROL OF WATER AND SODIUM-INTAKE, PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES 210: 165 (1980).","journal-title":"PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1152\/physrev.1972.52.2.468","volume":"52","year":"1972","unstructured":"FITZSIMONS, J. T., PHYSIOLOGICAL REVIEWS 52: 468 (1972).","journal-title":"PHYSIOLOGICAL REVIEWS"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BFb0030897","article-title":"Angiotensin stimulation of the central nervous system","volume":"87","year":"1980","unstructured":"Fitzsimons, J. T., Angiotensin stimulation of the central nervous system, Reviews of Physiology, Biochemistry and Pharmacology 87: 117 (1980).","journal-title":"Reviews of Physiology, Biochemistry and Pharmacology"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1159\/000122533","volume":"21","year":"1976","unstructured":"GEORGE, J.M., VASOPRESSIN AND OXYTOCIN CONTENT OF MICRODISSECTED HYPOTHALAMIC AREAS IN RATS WITH HEREDITARY DIABETES-INSIPIDUS, NEUROENDOCRINOLOGY 21: 275 (1976).","journal-title":"NEUROENDOCRINOLOGY"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1210\/endo-103-2-528","volume":"103","year":"1978","unstructured":"GILLIES, G, ENDOCRINOLOGY 103: 528 (1978).","journal-title":"ENDOCRINOLOGY"},{"key":"e_1_2_1_14_1","first-page":"173","volume":"30","year":"1972","unstructured":"GROSS, F, CIRCULATION RESEARCH 30 2: 173 (1972).","journal-title":"CIRCULATION RESEARCH"},{"key":"e_1_2_1_15_1","first-page":"116","volume":"28","year":"1974","unstructured":"GUTMAN, Y, EUR J PHARM 28: 116 (1974).","journal-title":"EUR J PHARM"},{"key":"e_1_2_1_16_1","first-page":"1081","volume":"10","year":"1971","unstructured":"GUTMAN, Y, EFFECT OF AN INCREASE AND OF LACK OF ANTIDIURETIC HORMONE ON PLASMA RENIN, LIFE SCIENCE PART 1 PHYSIOLOGY & PHARMACOLOGY 10: 1081 (1971).","journal-title":"LIFE SCIENCE PART 1 PHYSIOLOGY & PHARMACOLOGY"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF00584856","volume":"373","year":"1978","unstructured":"HACK, D, PFLUEGERS ARCH 373: 167 (1978).","journal-title":"PFLUEGERS ARCH"},{"key":"e_1_2_1_18_1","first-page":"67","volume":"6","year":"1980","unstructured":"HERBERT, E, FRONT NEUROENDOCRIN 6: 67 (1980).","journal-title":"FRONT NEUROENDOCRIN"},{"key":"e_1_2_1_19_1","first-page":"307","year":"1977","unstructured":"HOFFMAN, W.E., CENTRAL ACTIONS ANGI: 307 (1977).","journal-title":"CENTRAL ACTIONS ANGI"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/0028-3908(78)90132-6","volume":"17","year":"1978","unstructured":"HOFFMAN, W.E., RENIN AND ISORENIN-ANGIOTENSIN SYSTEM IN RATS WITH HEREDITARY HYPOTHALAMIC DIABETES-INSIPIDUS, NEUROPHARMACOLOGY 17: 919 (1978).","journal-title":"NEUROPHARMACOLOGY"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1210\/endo-96-4-1063","volume":"96","year":"1975","unstructured":"KEIL, L.C., RELEASE OF VASOPRESSIN BY ANGIOTENSIN-II, ENDOCRINOLOGY 96: 1063 (1975).","journal-title":"ENDOCRINOLOGY"},{"key":"e_1_2_1_22_1","first-page":"1880","volume":"77","year":"1980","unstructured":"LIOTTA, A.S., BIOSYNTHESIS OF PRECURSOR CORTICOTROPIN-ENDORPHIN-LIKE, CORTICOTROPIN-LIKE, ALPHA-MELANOTROPIN-LIKE, BETA-LIPOTROPIN-LIKE, AND BETA-ENDORPHIN-LIKE MATERIAL BY CULTURED NEONATAL RAT HYPOTHALAMIC NEURONS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 77: 1880 (1980).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_24_1","first-page":"3014","volume":"74","year":"1977","unstructured":"MAINS, R.E., COMMON PRECURSOR TO CORTICOTROPINS AND ENDORPHINS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 74: 3014 (1977).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_25_1","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/0024-3205(77)90115-1","volume":"21","year":"1977","unstructured":"MATA, M.M., EFFECT OF DEHYDRATION ON ENDOGENOUS OPIATE CONTENT OF RAT NEURO-INTERMEDIATE LOBE, LIFE SCIENCES 21: 1159 (1977).","journal-title":"LIFE SCIENCES"},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1210\/endo-79-6-1058","volume":"79","year":"1966","unstructured":"MCCANN, S.M., PITUITARY-ADRENAL FUNCTION IN ABSENCE OF VASOPRESSIN, ENDOCRINOLOGY 79: 1058 (1966).","journal-title":"ENDOCRINOLOGY"},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1152\/ajplegacy.1974.227.4.921","volume":"227","year":"1974","unstructured":"MOHRING, J, ACUTE EFFECTS OF VASOPRESSIN ON POTASSIUM AND WATER-BALANCE IN RATS WITH DIABETES-INSIPIDUS, AMERICAN JOURNAL OF PHYSIOLOGY 227: 921 (1974).","journal-title":"AMERICAN JOURNAL OF PHYSIOLOGY"},{"key":"e_1_2_1_28_1","first-page":"F106","volume":"234","year":"1978","unstructured":"MOHRING, J, EFFECTS OF PROLONGED VASOPRESSIN TREATMENT IN BRATTLEBORO RATS WITH DIABETES-INSIPIDUS, AMERICAN JOURNAL OF PHYSIOLOGY 234: F106 (1978).","journal-title":"AMERICAN JOURNAL OF PHYSIOLOGY"},{"key":"e_1_2_1_29_1","first-page":"154","year":"1973","unstructured":"OSTER, P, ACTA ENDOCRINOLOGICA 173: 154 (1973).","journal-title":"ACTA ENDOCRINOLOGICA"},{"key":"e_1_2_1_30_1","first-page":"R66","volume":"234","year":"1978","unstructured":"RAMSAY, D.J., ANGIOTENSIN-II INFUSION INCREASES VASOPRESSIN, ACTH, AND 11-HYDROXYCORTICOSTEROID SECRETION, AMERICAN JOURNAL OF PHYSIOLOGY 234: R66 (1978).","journal-title":"AMERICAN JOURNAL OF PHYSIOLOGY"},{"key":"e_1_2_1_31_1","first-page":"539","volume":"82","year":"1971","unstructured":"RAYYES, S.S., J CLIN ENDOCRINOL 82: 539 (1971).","journal-title":"J CLIN ENDOCRINOL"},{"key":"e_1_2_1_32_1","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/277653a0","volume":"277","year":"1979","unstructured":"ROSSIER, J, HYPOTHALAMIC ENKEPHALIN NEURONS MAY REGULATE THE NEUROHYPOPHYSIS, NATURE 277: 653 (1979).","journal-title":"NATURE"},{"key":"e_1_2_1_33_1","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1016\/0006-2952(80)90457-8","volume":"29","year":"1980","unstructured":"SANDER, G.E., INHIBITION OF THE PARTIALLY PURIFIED CANINE LUNG ANGIOTENSIN-I CONVERTING ENZYME BY OPIOID-PEPTIDES, BIOCHEMICAL PHARMACOLOGY 29: 3115 (1980).","journal-title":"BIOCHEMICAL PHARMACOLOGY"},{"key":"e_1_2_1_34_1","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/0024-3205(81)90182-X","volume":"29","year":"1981","unstructured":"SCHWARTZ, J.C., BIOLOGICAL INACTIVATION OF ENKEPHALINS AND THE ROLE OF ENKEPHALIN-DIPEPTIDYL-CARBOXYPEPTIDASE (ENKEPHALINASE) AS NEUROPEPTIDASE, LIFE SCIENCES 29: 1715 (1981).","journal-title":"LIFE SCIENCES"},{"key":"e_1_2_1_35_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1146\/annurev.bi.45.070176.000445","volume":"45","year":"1976","unstructured":"SOFFER, R.L., ANGIOTENSIN-CONVERTING ENZYME AND REGULATION OF VASOACTIVE PEPTIDES, ANNUAL REVIEW OF BIOCHEMISTRY 45: 73 (1976).","journal-title":"ANNUAL REVIEW OF BIOCHEMISTRY"},{"key":"e_1_2_1_36_1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1152\/ajplegacy.1964.206.2.425","volume":"206","year":"1964","unstructured":"VALTIN, H, FAMILIAL HYPOTHALAMIC DIABETES INSIPIDUS IN RATS ( BRATTLEBORO STRAIN ), AMERICAN JOURNAL OF PHYSIOLOGY 206: 425 (1964).","journal-title":"AMERICAN JOURNAL OF PHYSIOLOGY"},{"key":"e_1_2_1_37_1","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1210\/endo-77-4-701","volume":"77","year":"1965","unstructured":"VALTIN, H, NEUROHYPOPHYSIAL PRINCIPLES IN RATS HOMOZYGOUS AND HETEROZYGOUS FOR HYPOTHALAMIC DIABETES INSIPIDUS (BRATTLEBORO STRAIN), ENDOCRINOLOGY 77: 701 (1965).","journal-title":"ENDOCRINOLOGY"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/1961109a0"},{"key":"e_1_2_1_39_1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1161\/01.RES.23.5.605","volume":"23","year":"1968","unstructured":"VANDER, A.J., INHIBITION OF RENIN RELEASE IN DOG BY VASOPRESSIN AND VASOTOCIN, CIRCULATION RESEARCH 23: 605 (1968).","journal-title":"CIRCULATION RESEARCH"},{"key":"e_1_2_1_40_1","unstructured":"Van Houten M. paper presented at the tenth annual meeting of the Society for Neuroscience Cincinnati Ohio November (1980)."},{"key":"e_1_2_1_41_1","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1111\/j.1471-4159.1972.tb01298.x","volume":"19","year":"1972","unstructured":"YANG, HYT, DISTRIBUTION AND PROPERTIES OF ANGIOTENSIN CONVERTING ENZYME OF RAT-BRAIN, JOURNAL OF NEUROCHEMISTRY 19: 2443 (1972).","journal-title":"JOURNAL OF NEUROCHEMISTRY"},{"key":"e_1_2_1_42_1","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1111\/j.1471-4159.1973.tb07554.x","volume":"21","year":"1973","unstructured":"YANG, HYT, DIFFERENTIAL DISTRIBUTION OF ANGIOTENSIN CONVERTING ENZYME IN ANTERIOR AND POSTERIOR LOBE OF RAT PITUITARY, JOURNAL OF NEUROCHEMISTRY 21: 1035 (1973).","journal-title":"JOURNAL OF NEUROCHEMISTRY"},{"key":"e_1_2_1_43_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1210\/endo-88-1-3","volume":"88","year":"1971","unstructured":"YATES, F.E., POTENTIATION BY VASOPRESSIN OF CORTICOTROPIN RELEASE INDUCED BY CORTICOTROPIN-RELEASING FACTOR, ENDOCRINOLOGY 88: 3 (1971).","journal-title":"ENDOCRINOLOGY"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.182.4115.925"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.6280284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T23:33:21Z","timestamp":1705275201000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.6280284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,5,7]]},"references-count":44,"journal-issue":{"issue":"4546","published-print":{"date-parts":[[1982,5,7]]}},"alternative-id":["10.1126\/science.6280284"],"URL":"https:\/\/doi.org\/10.1126\/science.6280284","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"type":"print","value":"0036-8075"},{"type":"electronic","value":"1095-9203"}],"subject":[],"published":{"date-parts":[[1982,5,7]]}}}