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Except for the antibodies to nuclei, the monoclonal autoantibodies are organ-specific. Some, however, show broad cross-species reactivity, recognizing similar antigenic determinants in mouse, rat, pig, and human organs, whereas others recognize determinants only in rodent tissues. Several of the antigens recognized by these monoclonal autoantibodies have been identified as hormones (for example, glucagon, growth hormone, and insulin).<\/jats:p>","DOI":"10.1126\/science.6301002","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T18:37:18Z","timestamp":1160073438000},"page":"304-306","source":"Crossref","is-referenced-by-count":103,"title":["Virus-Induced Autoimmunity: Monoclonal Antibodies That React with Endocrine Tissues"],"prefix":"10.1126","volume":"220","author":[{"given":"Martin V.","family":"Haspel","sequence":"first","affiliation":[{"name":"Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Onodera","sequence":"additional","affiliation":[{"name":"Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 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