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Three nucleoside analogs, E-5-(2-bromovinyl)-2\u2032-deoxyuridine, 1-(2-deoxy-2-fluoro-\u03b2-D-arabinofuranosyl)-5-iodocytosine, and 1-(2-deoxy-2-fluoro-\u03b2-D-arabinofuranosyl)-5-methyluracil are potent inhibitors of EBV replication in vitro. Moreover, in contrast to the reversibility of viral inhibition by Acyclovir, these three drugs have prolonged effects in suppressing viral replication even after the drugs are removed from persistently infected cell cultures.<\/jats:p>","DOI":"10.1126\/science.6306771","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T18:37:18Z","timestamp":1160073438000},"page":"578-579","source":"Crossref","is-referenced-by-count":43,"title":["Epstein-Barr Virus: Inhibition of Replication by Three New Drugs"],"prefix":"10.1126","volume":"221","author":[{"given":"Jung-Chung","family":"Lin","sequence":"first","affiliation":[{"name":"Cancer Research Center and Departments of Biochemistry and Nutrition, School of Medicine, University of North Carolina, Chapel Hill 27514"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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