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Nonirradiated recipients failed to develop arthritis. However, such rats, and those recovering from cell-mediated arthritis, were resistant to subsequent attempts to induce adjuvant arthritis. Lines of T lymphocytes selected for responsiveness to other antigens had no effect. Therefore, a line of T lymphocytes responsive to bacteria or to collagen type II could either induce autoimmune arthritis or serve as an agent of vaccination against it.<\/jats:p>","DOI":"10.1126\/science.6336851","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T18:37:18Z","timestamp":1160073438000},"page":"56-58","source":"Crossref","is-referenced-by-count":330,"title":["Lines of T Lymphocytes Induce or Vaccinate Against Autoimmune Arthritis"],"prefix":"10.1126","volume":"219","author":[{"given":"Joseph","family":"Holoshitz","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel"},{"name":"Department of Medicine B, Meir General Hospital, Kfar-Saba 44815, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaakov","family":"Naparstek","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel"},{"name":"Department of Medicine A, Hadassah University Hospital, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avraham","family":"Ben-Nun","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irun R.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1084\/jem.146.4.1124","volume":"146","year":"1977","unstructured":"ANDERSSON, L, INDUCTION OF SPECIFIC IMMUNE UNRESPONSIVENESS USING PURIFIED MIXED LEUKOCYTE CULTURE-ACTIVATED T-LYMPHOBLASTS AS AUTOIMMUNOGEN .1. 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