{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:02:06Z","timestamp":1790679726912,"version":"4.1.0"},"reference-count":61,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4337","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1978,4,7]]},"abstract":"<jats:p>\n            Glucose reacts nonenzymatically with the NH\n            <jats:sub>2<\/jats:sub>\n            -terminal amino acid of the \u03b2 chain of human hemoglobin by way of a ketoamine linkage, resulting in the formation of hemoglobin A\n            <jats:sub>Ic<\/jats:sub>\n            . Other minor components appear to be adducts of glucose 6-phosphate and fructose 1,6-diphosphate. These hemoglobins are formed slowly and continuously throughout the 120-day life-span of the red cell. There is a two- to threefold increase in hemoglobin A\n            <jats:sub>Ic<\/jats:sub>\n            in the red cells of patients with diabetes mellitus. By providing an integrated measurement of blood glucose, hemoglobin A\n            <jats:sub>Ic<\/jats:sub>\n            is useful in assessing the degree of diabetic control. Furthermore, this hemoglobin is a useful model of nonenzymatic glycosylation of other proteins that may be involved in the long-term complications of the disease.\n          <\/jats:p>","DOI":"10.1126\/science.635569","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T12:35:25Z","timestamp":1160051725000},"page":"21-27","source":"Crossref","is-referenced-by-count":713,"title":["The Glycosylation of Hemoglobin: Relevance to Diabetes Mellitus"],"prefix":"10.1126","volume":"200","author":[{"given":"H. Franklin","family":"Bunn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth H.","family":"Gabbay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Gallop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/0005-2795(77)90022-8","volume":"490","year":"1977","unstructured":"ABDELLA, P.M., GLYCOSYLATION OF HEMOGLOBIN-S BY REDUCING SUGARS AND ITS EFFECT ON GELATION, BIOCHIMICA ET BIOPHYSICA ACTA 490: 462 (1977).","journal-title":"BIOCHIMICA ET BIOPHYSICA ACTA"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1365-2621.1973.tb01462.x","volume":"38","year":"1973","unstructured":"ADHIKARI, H.R., FLUORESCENT PRODUCTS IN A GLUCOSE-GLYCINE BROWNING REACTION, JOURNAL OF FOOD SCIENCE 38: 486 (1973).","journal-title":"JOURNAL OF FOOD SCIENCE"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1021\/ja01540a030","volume":"80","year":"1958","unstructured":"ALLEN, D.W., OBSERVATIONS ON THE CHROMATOGRAPHIC HETEROGENEITY OF NORMAL ADULT AND FETAL HUMAN HEMOGLOBIN - A STUDY OF THE EFFECTS OF CRYSTALLIZATION AND CHROMATOGRAPHY ON THE HETEROGENEITY AND ISOLEUCINE CONTENT, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 80: 1628 (1958).","journal-title":"JOURNAL OF THE AMERICAN CHEMICAL SOCIETY"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1021\/jf60205a004","volume":"24","year":"1976","unstructured":"AMAYA, J.F., BIOLOGICAL INACTIVATION OF PROTEINS BY MAILLARD REACTION - EFFECT OF MILD HEAT ON TERTIARY STRUCTURE OF INSULIN, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 24: 465 (1976).","journal-title":"JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/237146a0","volume":"237","year":"1972","unstructured":"ARNONE, A, X-RAY-DIFFRACTION STUDY OF BINDING OF 2,3-DIPHOSPHOGLYCERATE TO HUMAN DEOXYHEMOGLOBIN, NATURE 237: 146 (1972).","journal-title":"NATURE"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3109\/00365517409061816","volume":"34","year":"1974","unstructured":"ARTURSON, G, SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION 34: 19 (1974).","journal-title":"SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1182\/blood.V51.5.971.971","volume":"51","year":"1978","unstructured":"Basset, P., Blood 51: 971 (1978).","journal-title":"Blood"},{"key":"e_1_2_1_8_1","first-page":"1504","volume":"71","year":"1974","unstructured":"BENESCH, R, CHEMICAL MODIFICATIONS THAT INHIBIT GELATION OF SICKLE HEMOGLOBIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 71: 1504 (1974).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/0006-291X(68)90430-0","volume":"32","year":"1968","unstructured":"BOOKCHIN, R.M., STRUCTURE OF HEMOGLOBIN AIC - NATURE OF N-TERMINAL BETA CHAIN BLOCKING GROUP, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 32: 86 (1968).","journal-title":"BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0006-291X(75)90289-2","volume":"67","year":"1975","unstructured":"BUNN, H.F., FURTHER IDENTIFICATION OF NATURE AND LINKAGE OF CARBOHYDRATE IN HEMOGLOBIN-A1C, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 67: 103 (1975).","journal-title":"BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"},{"key":"e_1_2_1_11_1","unstructured":"Bunn H.F. Molecular Interactions of Hemoglobin (1978)."},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1172\/JCI106324","volume":"49","year":"1970","unstructured":"BUNN, H.F., INTERACTION OF 2,3-DIPHOSPHOGLYCERATE WITH VARIOUS HUMAN HEMOGLOBINS, JOURNAL OF CLINICAL INVESTIGATION 49: 1088 (1970).","journal-title":"JOURNAL OF CLINICAL INVESTIGATION"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1172\/JCI108436","volume":"57","year":"1976","unstructured":"BUNN, H.F., BIOSYNTHESIS OF HUMAN HEMOGLOBIN A1C - SLOW GLYCOSYLATION OF HEMOGLOBIN INVIVO, JOURNAL OF CLINICAL INVESTIGATION 57: 1652 (1976).","journal-title":"JOURNAL OF CLINICAL INVESTIGATION"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1038\/196948a0","volume":"196","year":"1962","unstructured":"Burton, H. S., Nature 196:948 (1962).","journal-title":"Nature"},{"key":"e_1_2_1_15_1","first-page":"357","volume":"3","year":"1974","unstructured":"CHARACHE, S, HAEMOGLOBINS WITH ALTERED OXYGEN AFFINITY, CLINICS IN HAEMATOLOGY 3: 357 (1974).","journal-title":"CLINICS IN HAEMATOLOGY"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1021\/jf60196a002","volume":"22","year":"1974","unstructured":"CLARK, A.V., ISOLATION AND CHARACTERIZATION OF PIGMENTS FROM PROTEIN-CARBONYL BROWNING SYSTEMS - MODELS FOR 2 INSULIN-GLUCOSE PIGMENTS, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 22: 1089 (1974).","journal-title":"JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0026-0495(78)90109-9","volume":"27","year":"1978","unstructured":"COLE, R. A., METABOLISM-CLINICAL AND EXPERIMENTAL 27: 289 (1978).","journal-title":"METABOLISM-CLINICAL AND EXPERIMENTAL"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2337\/diab.27.2.102","volume":"27","year":"1978","unstructured":"DAVIS, J.E., HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY METHOD FOR HEMOGLOBIN A1C, DIABETES 27: 102 (1978).","journal-title":"DIABETES"},{"key":"e_1_2_1_19_1","first-page":"59","year":"1975","unstructured":"DITZEL, J, ACTA MEDICA SCANDINAVICA 578: 59 (1975).","journal-title":"ACTA MEDICA SCANDINAVICA"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1042\/bj1290203","volume":"129","year":"1972","unstructured":"DIXON, HBF, REACTION OF GLUCOSE WITH PEPTIDES, BIOCHEMICAL JOURNAL 129: 203 (1972).","journal-title":"BIOCHEMICAL JOURNAL"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/0014-5793(78)81254-X","volume":"85","year":"1978","unstructured":"DOLHOFER, R, INVITRO GLYCOSYLATION OF HEMOGLOBINS BY DIFFERENT SUGARS AND SUGAR PHOSPHATES, FEBS LETTERS 85: 86 (1978).","journal-title":"FEBS LETTERS"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1007\/BF01479226","volume":"55","year":"1977","unstructured":"DOLHOFER, R, CLINICAL AND BIOCHEMICAL STUDIES ON SIGNIFICANCE AND FORMATION OF HEMOGLOBINS AIC AND AIA+B IN DIABETES-MELLITUS, KLINISCHE WOCHENSCHRIFT 55: 945 (1977).","journal-title":"KLINISCHE WOCHENSCHRIFT"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1172\/JCI108534","volume":"58","year":"1976","unstructured":"FITZGIBBONS, J.F., RED-CELL AGE-RELATED-CHANGES OF HEMOGLOBINS AIA+B AND AIC IN NORMAL AND DIABETIC SUBJECTS, JOURNAL OF CLINICAL INVESTIGATION 58: 820 (1976).","journal-title":"JOURNAL OF CLINICAL INVESTIGATION"},{"key":"e_1_2_1_24_1","unstructured":"Fluckiger R. Molecular Interactions of Hemoglobin (1978)."},{"key":"e_1_2_1_25_1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/0014-5793(76)80969-6","volume":"71","year":"1976","unstructured":"FLUCKIGER, R, INVITRO SYNTHESIS OF HEMOGLOBIN AIC, FEBS LETTERS 71: 356 (1976).","journal-title":"FEBS LETTERS"},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1146\/annurev.me.26.020175.002513","volume":"26","year":"1975","unstructured":"GABBAY, K.H., HYPERGLYCEMIA, POLYOL METABOLISM, AND COMPLICATIONS OF DIABETES-MELLITUS, ANNUAL REVIEW OF MEDICINE 26: 521 (1975).","journal-title":"ANNUAL REVIEW OF MEDICINE"},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1210\/jcem-44-5-859","volume":"44","year":"1977","unstructured":"GABBAY, K.H., GLYCOSYLATED HEMOGLOBINS AND LONG-TERM BLOOD-GLUCOSE CONTROL IN DIABETES-MELLITUS, JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 44: 859 (1977).","journal-title":"JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM"},{"key":"e_1_2_1_28_1","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1152\/physrev.1975.55.3.418","volume":"55","year":"1975","unstructured":"GALLOP, P.M., POSTTRANSLATIONAL PROTEIN MODIFICATIONS, WITH SPECIAL ATTENTION TO COLLAGEN AND ELASTIN, PHYSIOLOGICAL REVIEWS 55: 418 (1975).","journal-title":"PHYSIOLOGICAL REVIEWS"},{"key":"e_1_2_1_29_1","first-page":"734","volume":"2","year":"1977","unstructured":"GONEN, B, HEMOGLOBIN-A1 - INDICATOR OF METABOLIC CONTROL OF DIABETIC-PATIENTS, LANCET 2: 734 (1977).","journal-title":"LANCET"},{"key":"e_1_2_1_30_1","first-page":"368","volume":"26","year":"1977","unstructured":"GRAF, R. J., DIABETES 26: 368 (1977).","journal-title":"DIABETES"},{"key":"e_1_2_1_31_1","first-page":"3534","volume":"73","year":"1976","unstructured":"HANEY, D.N., GLYCOSYLATION OF HEMOGLOBIN INVITRO - AFFINITY LABELING OF HEMOGLOBIN BY GLUCOSE-6-PHOSPHATE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 73: 3534 (1976).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_32_1","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1021\/bi00872a002","volume":"5","year":"1966","unstructured":"HOLMQUIST, W.R., A NEW N-TERMINAL BLOCKING GROUP INVOLVING A SCHIFF BASE IN HEMOGLOBIN A1C, BIOCHEMISTRY 5: 2489 (1966).","journal-title":"BIOCHEMISTRY"},{"key":"e_1_2_1_33_1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1365-2141.1965.tb06589.x","volume":"11","year":"1965","unstructured":"HORTON, B.F., STUDIES ON HETEROGENEITY OF HAEMOGLOBIN .7. MINOR HAEMOGLOBIN COMPONENTS IN HAEMATOLOGICAL DISEASES, BRITISH JOURNAL OF HAEMATOLOGY 11: 296 (1965).","journal-title":"BRITISH JOURNAL OF HAEMATOLOGY"},{"key":"e_1_2_1_34_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0009-8981(60)90098-X","volume":"5","year":"1960","unstructured":"HUISMAN, THJ, STUDIES ON THE HETEROGENEITY OF HEMOGLOBIN .1. THE HETEROGENEITY OF DIFFERENT HUMAN HEMOGLOBIN TYPES IN CARBOXYMETHYLCELLULOSE AND IN AMBERLITE IRC-50 CHROMATOGRAPHY - QUALITATIVE ASPECTS, CLINICA CHIMICA ACTA 5: 103 (1960).","journal-title":"CLINICA CHIMICA ACTA"},{"key":"e_1_2_1_35_1","first-page":"302","volume":"60","year":"1962","unstructured":"HUISMAN, THJ, STUDIES ON HETEROGENEITY OF HEMOGLOBIN .5. BINDING OF HEMOGLOBIN WITH OXIDIZED GLUTATHIONE, JOURNAL OF LABORATORY AND CLINICAL MEDICINE 60: 302 (1962).","journal-title":"JOURNAL OF LABORATORY AND CLINICAL MEDICINE"},{"key":"e_1_2_1_36_1","first-page":"110","volume":"50","year":"1977","unstructured":"JAVID, J, BLOOD 50: 110 (1977).","journal-title":"BLOOD"},{"key":"e_1_2_1_37_1","doi-asserted-by":"crossref","first-page":"7039","DOI":"10.1016\/S0021-9258(19)43357-7","volume":"248","year":"1973","unstructured":"KILMARTIN, J.V., ROLE OF ALPHA-AMINO GROUPS OF ALPHA AND BETA CHAINS OF HUMAN HEMOGLOBIN IN OXYGEN-LINKED BINDING OF CARBON-DIOXIDE, JOURNAL OF BIOLOGICAL CHEMISTRY 248: 7039 (1973).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_38_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2337\/diab.25.1.1","volume":"25","year":"1976","unstructured":"KOENIG, R.J., INCREASED HEMOGLOBIN AIC IN DIABETIC MICE, DIABETES 25: 1 (1976).","journal-title":"DIABETES"},{"key":"e_1_2_1_39_1","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1016\/S0021-9258(17)40461-3","volume":"252","year":"1977","unstructured":"KOENIG, R.J., STRUCTURE OF CARBOHYDRATE OF HEMOGLOBIN AIC, JOURNAL OF BIOLOGICAL CHEMISTRY 252: 2992 (1977).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_40_1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1056\/NEJM197608192950804","volume":"295","year":"1976","unstructured":"KOENIG, R.J., CORRELATION OF GLUCOSE REGULATION AND HEMOGLOBIN-A-IC IN DIABETES-MELLITUS, NEW ENGLAND JOURNAL OF MEDICINE 295: 417 (1976).","journal-title":"NEW ENGLAND JOURNAL OF MEDICINE"},{"key":"e_1_2_1_41_1","first-page":"3687","volume":"72","year":"1975","unstructured":"KOENING, R.J., SYNTHESIS OF HEMOGLOBIN AIC IN NORMAL AND DIABETIC MICE - POTENTIAL MODEL OF BASEMENT-MEMBRANE THICKENING, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 72: 3687 (1975).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_42_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev.bi.45.070176.001245","volume":"45","year":"1976","unstructured":"KORNFELD, S, ANN REV BIOCH 45: 217 (1976).","journal-title":"ANN REV BIOCH"},{"key":"e_1_2_1_43_1","unstructured":"Krishnamoorthy R. Molecular Interactions of Hemoglobin (1978)."},{"key":"e_1_2_1_44_1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0014-5793(77)80201-9","volume":"77","year":"1977","unstructured":"KRISHNAMOORTHY, R, ISOLATION AND PARTIAL CHARACTERIZATION OF HEMOGLOBIN A1B, FEBS LETTERS 77: 99 (1977).","journal-title":"FEBS LETTERS"},{"key":"e_1_2_1_45_1","unstructured":"McDonald M. J. Biophysical Journal in press."},{"key":"e_1_2_1_46_1","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1016\/S0021-9258(17)38076-6","volume":"253","year":"1978","unstructured":"McDonald, M. J., Journal of Biological Chemistry 253: 2327 (1978).","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_1_47_1","doi-asserted-by":"crossref","first-page":"6611","DOI":"10.1016\/S0021-9258(19)42200-X","volume":"249","year":"1974","unstructured":"NIGEN, A.M., STUDIES ON MECHANISM OF ACTION OF CYANATE IN SICKLE-CELL DISEASE - OXYGEN-AFFINITY AND GELLING PROPERTIES OF HEMOGLOBIN S CARBAMYLATED ON SPECIFIC CHAINS, JOURNAL OF BIOLOGICAL CHEMISTRY 249: 6611 (1974).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_48_1","first-page":"367","volume":"74","year":"1977","unstructured":"NIGEN, A.M., INHIBITION OF ERYTHROCYTE SICKLING INVITRO BY DL-GLYCERALDEHYDE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 74: 367 (1977).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_49_1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0026-0495(73)90170-4","volume":"22","year":"1973","unstructured":"PAULSEN, E. P., METABOLISM-CLINICAL AND EXPERIMENTAL 22: 269 (1973).","journal-title":"METABOLISM-CLINICAL AND EXPERIMENTAL"},{"key":"e_1_2_1_50_1","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/0006-291X(69)90685-8","volume":"36","year":"1969","unstructured":"RAHBAR, S, STUDIES OF AN UNUSUAL HEMOGLOBIN IN PATIENTS WITH DIABETES MELLITUS, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 36: 838 (1969).","journal-title":"BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"},{"key":"e_1_2_1_51_1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/0009-8981(68)90372-0","volume":"22","year":"1968","unstructured":"RAHBAR, S, AN ABNORMAL HEMOGLOBIN IN RED CELLS OF DIABETICS, CLINICA CHIMICA ACTA 22: 296 (1968).","journal-title":"CLINICA CHIMICA ACTA"},{"key":"e_1_2_1_52_1","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1172\/JCI103828","volume":"38","year":"1959","unstructured":"RANNEY, A.M., JOURNAL OF CLINICAL INVESTIGATION 38: 508 (1959).","journal-title":"JOURNAL OF CLINICAL INVESTIGATION"},{"key":"e_1_2_1_53_1","first-page":"1451","volume":"33","year":"1974","unstructured":"RITCHEY, J. M., FEDERATION PROCEEDINGS 33: 1451 (1974).","journal-title":"FEDERATION PROCEEDINGS"},{"key":"e_1_2_1_54_1","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.2337\/diab.25.12.1118","volume":"25","year":"1976","unstructured":"SCHWARTZ, H.C., EFFECTS OF PREGNANCY ON HEMOGLOBIN AIC IN NORMAL, GESTATIONAL DIABETIC, AND DIABETIC WOMEN, DIABETES 25: 1118 (1976).","journal-title":"DIABETES"},{"key":"e_1_2_1_55_1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0065-3233(08)60451-9","volume":"27","year":"1973","unstructured":"SPIRO, R. G., ADVANCES IN PROTEIN CHEMISTRY 27: 349 (1973).","journal-title":"ADVANCES IN PROTEIN CHEMISTRY"},{"key":"e_1_2_1_56_1","doi-asserted-by":"crossref","first-page":"2998","DOI":"10.1016\/S0021-9258(17)40462-5","volume":"252","year":"1977","unstructured":"STEVENS, V.J., NONENZYMATIC GLYCOSYLATION OF HEMOGLOBIN, JOURNAL OF BIOLOGICAL CHEMISTRY 252: 2998 (1977).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_57_1","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1056\/NEJM197512042932304","volume":"293","year":"1975","unstructured":"TATTERSALL, R.B., HEMOGLOBIN COMPONENTS IN DIABETES-MELLITUS - STUDIES IN IDENTICAL-TWINS, NEW ENGLAND JOURNAL OF MEDICINE 293: 1171 (1975).","journal-title":"NEW ENGLAND JOURNAL OF MEDICINE"},{"key":"e_1_2_1_58_1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1056\/NEJM197102182840703","volume":"284","year":"1971","unstructured":"TRIVELLI, L.A., HEMOGLOBIN COMPONENTS IN PATIENTS WITH DIABETES MELLITUS, NEW ENGLAND JOURNAL OF MEDICINE 284: 353 (1971).","journal-title":"NEW ENGLAND JOURNAL OF MEDICINE"},{"key":"e_1_2_1_59_1","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1126\/science.337487","volume":"198","year":"1977","unstructured":"UY, R, POST-TRANSLATIONAL COVALENT MODIFICATION OF PROTEINS, SCIENCE 198: 890 (1977).","journal-title":"SCIENCE"},{"key":"e_1_2_1_60_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1146\/annurev.bi.45.070176.000523","volume":"45","year":"1976","unstructured":"WAECHTER, C.J., ROLE OF POLYPRENOL-LINKED SUGARS IN GLYCOPROTEIN SYNTHESIS, ANNUAL REVIEW OF BIOCHEMISTRY 45: 95 (1976).","journal-title":"ANNUAL REVIEW OF BIOCHEMISTRY"},{"key":"e_1_2_1_61_1","first-page":"3","volume":"4","year":"1971","unstructured":"WINTERHALTER, K.H., SERIES HAEMATOLOGICA 4: 3 (1971).","journal-title":"SERIES HAEMATOLOGICA"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.635569","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T18:33:59Z","timestamp":1705257239000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.635569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,4,7]]},"references-count":61,"journal-issue":{"issue":"4337","published-print":{"date-parts":[[1978,4,7]]}},"alternative-id":["10.1126\/science.635569"],"URL":"https:\/\/doi.org\/10.1126\/science.635569","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,4,7]]}}}