{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:23:34Z","timestamp":1790940214147,"version":"4.1.0"},"reference-count":41,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4643","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1984,3,30]]},"abstract":"<jats:p>Type I diabetes may be an autoimmune disorder, although the evidence is largely circumstantial. The natural history of the disease after diagnosis includes partial remission in most patients, but only about 3 percent achieve transient insulin independence. \u03b2 Cell function, as indicated by the plasma concentration of C-peptide, is lost over 6 to 30 months and islet cell antibodies disappeared over 1 to 2 years. This article describes a pilot study in which 41 patients were treated with the immunosuppressive agent cyclosporine for 2 to 12 months. Of 30 patients treated within 6 weeks of diagnosis, 16 became insulin independent with concentrations of plasma C-peptide in the normal range and decreasing titers of islet cell antibodies. Of 11 patients who entered the study 8 to 44 weeks after diagnosis, two achieved this state. These results indicate that a controlled trial of the effects of cyclosporine in type I diabetes should be conducted.<\/jats:p>","DOI":"10.1126\/science.6367043","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T19:41:59Z","timestamp":1160077319000},"page":"1362-1367","source":"Crossref","is-referenced-by-count":465,"title":["Effects of Cyclosporine Immunosuppression in Insulin-Dependent Diabetes Mellitus of Recent Onset"],"prefix":"10.1126","volume":"223","author":[{"given":"C. R.","family":"Stiller","sequence":"first","affiliation":[{"name":"University Hospital, London, Ontario N6A 5A5 and the University of Western Ontario, London, Ontario N6G 2K3, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Dupr\u00e9","sequence":"additional","affiliation":[{"name":"University Hospital, London, Ontario N6A 5A5 and the University of Western Ontario, London, Ontario N6G 2K3, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gent","sequence":"additional","affiliation":[{"name":"University Hospital, London, Ontario N6A 5A5 and the University of Western Ontario, London, Ontario N6G 2K3, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"Jenner","sequence":"additional","affiliation":[{"name":"University Hospital, London, Ontario N6A 5A5 and the University of Western Ontario, London, Ontario N6G 2K3, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. A.","family":"Keown","sequence":"additional","affiliation":[{"name":"University Hospital, London, Ontario N6A 5A5 and the University of Western Ontario, London, Ontario N6G 2K3, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Laupacis","sequence":"additional","affiliation":[{"name":"University Hospital, London, Ontario N6A 5A5 and the University of Western Ontario, London, Ontario N6G 2K3, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Martell","sequence":"additional","affiliation":[{"name":"University Hospital, London, Ontario N6A 5A5 and the University of Western Ontario, London, Ontario N6G 2K3, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. W.","family":"Rodger","sequence":"additional","affiliation":[{"name":"University Hospital, London, Ontario N6A 5A5 and the University of Western Ontario, London, Ontario N6G 2K3, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"von Graffenried","sequence":"additional","affiliation":[{"name":"University Hospital, London, Ontario N6A 5A5 and the University of Western Ontario, London, Ontario N6G 2K3, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. M. 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