{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T20:37:32Z","timestamp":1718656652072},"reference-count":16,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4678","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1984,11,30]]},"abstract":"<jats:p>A chemically selective procedure for covalent modification of Schiff base-forming binding sites in proteins is demonstrated in vitro. In vivo studies show that the same procedure produces a selective anosmia (\"odor blindness\") when applied to the olfactory epithelia of experimental animals. Surgical experiments confirm that the sense of smell is specifically affected.<\/jats:p>","DOI":"10.1126\/science.6494927","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T15:41:59Z","timestamp":1160062919000},"page":"1092-1094","source":"Crossref","is-referenced-by-count":16,"title":["Selective Deficits in the Sense of Smell Caused by Chemical Modification of the Olfactory Epithelium"],"prefix":"10.1126","volume":"226","author":[{"given":"J. Russell","family":"Mason","sequence":"first","affiliation":[{"name":"Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Clark","sequence":"additional","affiliation":[{"name":"Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas Hellman","family":"Morton","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of California, Riverside 92521"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1021\/ja00394a071","volume":"103","year":"1981","unstructured":"Benner, S. A., Journal of the American Chemical Society 103: 993 (1981).","journal-title":"Journal of the American Chemical Society"},{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6968976"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0304-3940(83)90439-1","volume":"37","year":"1983","unstructured":"DELALEU, J.C., INVESTIGATIONS OF THE DISCRIMINATIVE PROPERTIES OF THE FROGS OLFACTORY MUCOSA USING A PHOTOACTIVABLE ODORANT, NEUROSCIENCE LETTERS 37: 251 (1983).","journal-title":"NEUROSCIENCE LETTERS"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.1021\/ja00875a050","volume":"84","year":"1962","unstructured":"FRIDOVICH, I, ON MECHANISM OF ENZYMATIC DECARBOXYLATION OF ACETOACETATE .2., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 84: 3208 (1962).","journal-title":"JOURNAL OF THE AMERICAN CHEMICAL SOCIETY"},{"key":"e_1_2_1_5_1","first-page":"1494","volume":"69","year":"1972","unstructured":"GETCHELL, M.L., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 69: 1494 (1972).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1021\/ja00839a050","volume":"97","year":"1975","unstructured":"HAMMONS, G.H., PROTON-EXCHANGE REACTIONS OF ACETONE AND BUTANONE - RESOLUTION OF STEPS IN CATALYSIS BY ACETOACETATE DECARBOXYLASE, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 97: 1568 (1975).","journal-title":"JOURNAL OF THE AMERICAN CHEMICAL SOCIETY"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1021\/bi00702a013","volume":"13","year":"1974","unstructured":"KLUGER, R, INHIBITION OF ACETOACETATE DECARBOXYLASE BY KETOPHOSPHONATES - STRUCTURAL AND DYNAMIC PROBES OF ACTIVE-SITE, BIOCHEMISTRY 13: 910 (1974).","journal-title":"BIOCHEMISTRY"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/0031-9384(82)90243-8","volume":"29","year":"1982","unstructured":"MASON, J.R., TEMPORARY AND SELECTIVE ANOSMIA IN TIGER SALAMANDERS (AMBYSTOMA-TIGRINUM) CAUSED BY CHEMICAL TREATMENT OF THE OLFACTORY EPITHELIUM, PHYSIOLOGY & BEHAVIOR 29: 709 (1982).","journal-title":"PHYSIOLOGY & BEHAVIOR"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/0040-4020(84)85053-X","volume":"40","year":"1984","unstructured":"MASON, J.R., FAST AND LOOSE COVALENT BINDING OF KETONES AS A MOLECULAR MECHANISM IN VERTEBRATE OLFACTORY RECEPTORS - CHEMICAL PRODUCTION OF SELECTIVE ANOSMIA, TETRAHEDRON 40: 483 (1984).","journal-title":"TETRAHEDRON"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1021\/bk-1981-0148.ch012","volume":"148","year":"1981","unstructured":"MOULTON, D.G., ACS SYMPOSIUM SERIES 148: 211 (1981).","journal-title":"ACS SYMPOSIUM SERIES"},{"key":"e_1_2_1_11_1","first-page":"69","year":"1981","unstructured":"PRICE, S, BIOCH TASTE OLFACTIO: 69 (1981).","journal-title":"BIOCH TASTE OLFACTIO"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/chemse\/8.4.341","volume":"8","year":"1984","unstructured":"PRICE, S, MECHANISMS OF STIMULATION OF OLFACTORY NEURONS - AN ESSAY, CHEMICAL SENSES 8: 341 (1984).","journal-title":"CHEMICAL SENSES"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/chemse\/9.1.31","volume":"9","year":"1984","unstructured":"SCHAFER, R, OLFACTORY STUDIES USING ETHYL BROMOACETATE AND OTHER CHEMICALLY ACTIVE ODORANTS, CHEMICAL SENSES 9: 31 (1984).","journal-title":"CHEMICAL SENSES"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/chemse\/9.1.55","volume":"9","year":"1984","unstructured":"SCHAFER, R, PROTECTION OF OLFACTORY RESPONSES FROM INHIBITION BY ETHYL BROMOACETATE, DIETHYLAMINE, AND OTHER CHEMICALLY ACTIVE ODORANTS BY CERTAIN ESTERS AND OTHER COMPOUNDS, CHEMICAL SENSES 9: 55 (1984).","journal-title":"CHEMICAL SENSES"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0076-6879(69)14045-8","volume":"14","year":"1969","unstructured":"WESTHEIMER, F.H., METHODS IN ENZYMOLOGY 14: 231 (1969).","journal-title":"METHODS IN ENZYMOLOGY"},{"key":"e_1_2_1_16_1","first-page":"7","volume":"15","year":"1971","unstructured":"WESTHEIMER, F.H., P RA WELCH FDN C CHE 15: 7 (1971).","journal-title":"P RA WELCH FDN C CHE"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.6494927","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T18:30:53Z","timestamp":1705257053000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.6494927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,11,30]]},"references-count":16,"journal-issue":{"issue":"4678","published-print":{"date-parts":[[1984,11,30]]}},"alternative-id":["10.1126\/science.6494927"],"URL":"https:\/\/doi.org\/10.1126\/science.6494927","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,11,30]]}}}