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Peripheral blood lymphocytes from one patient in the United States and two in France were cultured with T-cell growth factor (TCGF) an shown to express HTLV antigens. Virus from the U.S. patient was isolated and characterized and shown to be related to HTLV subgroup I. The virus was also transmitted into normal human T cells from umbilical cord blood of a newborn. Whether or not HTLV-I or other retroviruses of this family with T-cell tropism cause AIDS, it is possible that patients from whom the virus can be isolated can also transmit it to others. If the target cell of AIDS is the mature T cell as suspected, the methods used in these studies may prove useful for the long-term growth of these cells and for the identification of antigens specific for the etiological agent of AIDS.<\/jats:p>","DOI":"10.1126\/science.6601823","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T14:37:18Z","timestamp":1160059038000},"page":"865-867","source":"Crossref","is-referenced-by-count":887,"title":["Isolation of Human T-Cell Leukemia Virus in Acquired Immune Deficiency Syndrome (AIDS)"],"prefix":"10.1126","volume":"220","author":[{"given":"Robert C.","family":"Gallo","sequence":"first","affiliation":[{"name":"Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prem S.","family":"Sarin","sequence":"additional","affiliation":[{"name":"Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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