{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T07:05:43Z","timestamp":1762067143995},"reference-count":12,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4347","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1978,6,16]]},"abstract":"<jats:p>\n            Antibodies to insulin receptors purified from rat liver membranes do not complete with [\n            <jats:sup>125<\/jats:sup>\n            I]insulin for binding to the insulin receptor but do precipitate solubilized receptors labeled with [\n            <jats:sup>125<\/jats:sup>\n            I]insulin. These antibodies have the insulin-like activities of enhancing glucose oxidation and inhibiting epinephrine-induced lipolysis in rat adipocytes. Thus, antibody binds to the receptor at a different site from that to which insulin binds, yet the interaction can initiate an effective biological response. These results indicate that the previously studied insulin-binding sites are the physiological macromolecular receptors for insulin.\n          <\/jats:p>","DOI":"10.1126\/science.663609","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T16:35:25Z","timestamp":1160066125000},"page":"1283-1284","source":"Crossref","is-referenced-by-count":143,"title":["Antibodies to Purified Insulin Receptor Have Insulin-Like Activity"],"prefix":"10.1126","volume":"200","author":[{"given":"Steven","family":"Jacobs","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, Wellcome Research Laboratories, Research Triangle Park, North Carolina 27709"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwen-Jen","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Wellcome Research Laboratories, Research Triangle Park, North Carolina 27709"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Cuatrecasas","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Wellcome Research Laboratories, Research Triangle Park, North Carolina 27709"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0076-6879(69)14061-6","volume":"14","year":"1969","unstructured":"Chernick, S. S., Methods in Enzymology 14: 627 (1969).","journal-title":"Methods in Enzymology"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0065-3233(08)60481-7","volume":"30","year":"1976","unstructured":"CUATRECASAS, P, ADVANCES IN PROTEIN CHEMISTRY 30: 251 (1976).","journal-title":"ADVANCES IN PROTEIN CHEMISTRY"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0006-291X(75)80401-3","volume":"62","year":"1975","unstructured":"CUATRECASAS, P, BINDING OF INSULIN AND OTHER HORMONES TO NON-RECEPTOR MATERIALS - SATURABILITY, SPECIFICITY AND APPARENT NEGATIVE-COOPERATIVITY, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 62: 31 (1975).","journal-title":"BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"},{"key":"e_1_2_1_4_1","first-page":"318","volume":"69","year":"1972","unstructured":"CUATRECASAS, P, ISOLATION OF INSULIN RECEPTOR OF LIVER AND FAT-CELL MEMBRANES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 69: 318 (1972).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_5_1","first-page":"1277","volume":"69","year":"1972","unstructured":"CUATRECASAS, P, AFFINITY CHROMATOGRAPHY AND PURIFICATION OF INSULIN RECEPTOR OF LIVER-CELL MEMBRANES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 69: 1277 (1972).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_6_1","first-page":"485","volume":"70","year":"1973","unstructured":"CUATRECASAS, P, INSULIN-LIKE ACTIVITY OF CONCANAVALIN A AND WHEAT-GERM AGGLUTININ - DIRECT INTERACTIONS WITH INSULIN RECEPTORS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 70: 485 (1973).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1172\/JCI108600","volume":"58","year":"1976","unstructured":"FLIER, J.S., CHARACTERIZATION OF ANTIBODIES TO INSULIN RECEPTOR - CAUSE OF INSULIN-RESISTANT DIABETES IN MAN, JOURNAL OF CLINICAL INVESTIGATION 58: 1442 (1976).","journal-title":"JOURNAL OF CLINICAL INVESTIGATION"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.170678"},{"key":"e_1_2_1_9_1","first-page":"3090","volume":"74","year":"1977","unstructured":"HEINEMANN, S, MODULATION OF ACETYLCHOLINE-RECEPTOR BY ANTIBODY AGAINST RECEPTOR, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 74: 3090 (1977).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/S0006-291X(77)80074-0","volume":"77","year":"1977","unstructured":"JACOBS, S, PURIFICATION AND PROPERTIES OF INSULIN RECEPTORS FROM RAT-LIVER MEMBRANES, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 77: 981 (1977).","journal-title":"BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"},{"key":"e_1_2_1_11_1","unstructured":"JACOBS S UNPUBLISHED."},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1172\/JCI108861","volume":"60","year":"1977","unstructured":"KAHN, C.R., EFFECTS OF AUTOANTIBODIES TO INSULIN RECEPTOR ON ISOLATED ADIPOCYTES - STUDIES OF INSULIN BINDING AND INSULIN ACTION, JOURNAL OF CLINICAL INVESTIGATION 60: 1094 (1977).","journal-title":"JOURNAL OF CLINICAL INVESTIGATION"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.663609","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T23:28:58Z","timestamp":1705274938000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.663609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,6,16]]},"references-count":12,"journal-issue":{"issue":"4347","published-print":{"date-parts":[[1978,6,16]]}},"alternative-id":["10.1126\/science.663609"],"URL":"https:\/\/doi.org\/10.1126\/science.663609","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,6,16]]}}}