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These results strikingly confirm the hypothesis that carrier-mediated blood-brain transport is the limiting factor determining the availability of the neutral amino acids to the brain. The encephalopathy associated with cirrhosis may be the result of abnormal neurotransmitter metabolism and neurotransmission secondary to increased neutral amino acid transport activity and an increased brain content of members of the neutral amino acid group.<\/jats:p>","DOI":"10.1126\/science.663619","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T16:35:25Z","timestamp":1160066125000},"page":"1395-1397","source":"Crossref","is-referenced-by-count":217,"title":["Blood-Brain Neutral Amino Acid Transport Activity Is Increased After Portacaval Anastomosis"],"prefix":"10.1126","volume":"200","author":[{"given":"J. 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