{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T17:30:13Z","timestamp":1771003813563,"version":"3.50.1"},"reference-count":22,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4643","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1984,3,30]]},"abstract":"<jats:p>A small virus resembling parvoviruses in its morphological and physicochemical properties was derived from synovial tissue of a patient with severe rheumatoid arthritis. This virus, designated RA-1, elicits a syndrome in neonatal mice that includes neurological disturbances, permanent crippling of limbs, dwarfism, alopecia, blepharitis, \"masking,\" and a rigid curvature of the thoracic spine. Polyclonal antibodies against RA-1 display high virus neutralizing activity and in immunoassays detect reactive antigen in synovial cells from different rheumatoid arthritis patients but not persons with osteoarthritis. Putative parvoviruses isolated from several other rheumatoid arthritis patients are only weakly pathogenic for newborn mice but can generate RA-1 virus-specific antigens in tissues of these animals. It has not been established that RA-1 and existing parvoviruses of mammalian species are related.<\/jats:p>","DOI":"10.1126\/science.6701529","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T19:41:59Z","timestamp":1160077319000},"page":"1425-1428","source":"Crossref","is-referenced-by-count":96,"title":["Association of Parvoviruses with Rheumatoid Arthritis of Humans"],"prefix":"10.1126","volume":"223","author":[{"given":"Robert W.","family":"Simpson","sequence":"first","affiliation":[{"name":"Waksman Institute of Microbiology, Rutgers University, Piscataway, New Jersey 08854"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurel","family":"McGinty","sequence":"additional","affiliation":[{"name":"Waksman Institute of Microbiology, Rutgers University, Piscataway, New Jersey 08854"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee","family":"Simon","sequence":"additional","affiliation":[{"name":"Waksman Institute of Microbiology, Rutgers University, Piscataway, New Jersey 08854"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol A.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Medicine, Montefiore Hospital, Albert Einstein College of Medicine, Bronx, New York 10467"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl W.","family":"Godzeski","sequence":"additional","affiliation":[{"name":"Department of Immunology and Connective Tissue Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Boyd","sequence":"additional","affiliation":[{"name":"Department of Immunology and Connective Tissue Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0022172400070480","volume":"89","year":"1982","unstructured":"ANDERSON, M.J., THE EMERGING STORY OF A HUMAN PARVOVIRUS-LIKE AGENT, JOURNAL OF HYGIENE 89: 1 (1982).","journal-title":"JOURNAL OF HYGIENE"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1128\/jvi.33.2.739-748.1980","volume":"33","year":"1980","unstructured":"CHEUNG, AKM, INTEGRATION OF THE ADENO-ASSOCIATED VIRUS GENOME INTO CELLULAR DNA IN LATENTLY INFECTED HUMAN DETROIT-6 CELLS, JOURNAL OF VIROLOGY 33: 739 (1980).","journal-title":"JOURNAL OF VIROLOGY"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6153243"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.142303"},{"key":"e_1_2_1_5_1","unstructured":"Garrod A. 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