{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:49:07Z","timestamp":1791118147570,"version":"4.1.0"},"reference-count":14,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4649","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1984,5,11]]},"abstract":"<jats:p>\n            Protozoan parasites of the genus\n            <jats:italic>Cryptosporidium<\/jats:italic>\n            cause a short-term, flu-like, gastrointestinal illness in immunocompetent persons and severe, persistent, life-threatening diarrhea in immunodeficient individuals. No effective therapy is available for the treatment of cryptosporidiosis in the immunodeficient host. Complete development (from sporozoite to sporulated oocyst) of a human isolate of\n            <jats:italic>Cryptosporidium<\/jats:italic>\n            was achieved in cultured human fetal lung cells and primary chicken kidney and porcine kidney cells. The growth of this newly recognized zoonotic agent in cell culture now provides a means of studying its behavior, development, and metabolism, and a mechanism for evaluation of potentially useful therapeutic agents.\n          <\/jats:p>","DOI":"10.1126\/science.6710159","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T19:41:59Z","timestamp":1160077319000},"page":"603-605","source":"Crossref","is-referenced-by-count":128,"title":["Complete Development of\n            <i>Cryptosporidium<\/i>\n            in Cell Culture"],"prefix":"10.1126","volume":"224","author":[{"given":"William L.","family":"Current","sequence":"first","affiliation":[{"name":"Department of Zoology-Entomology, Auburn University, Alabama 36849"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas B.","family":"Haynes","sequence":"additional","affiliation":[{"name":"Department of Zoology-Entomology, Auburn University, Alabama 36849"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"589","volume":"31","year":"1982","unstructured":"MORBIDITY AND MORTALITY WEEKLY REPORT 31: 589 (1982).","journal-title":"MORBIDITY AND MORTALITY WEEKLY REPORT"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/infdis\/148.4.772","volume":"148","year":"1983","unstructured":"BLAGBURN, B.L., ACCIDENTAL INFECTION OF A RESEARCHER WITH HUMAN CRYPTOSPORIDIUM, JOURNAL OF INFECTIOUS DISEASES 148: 772 (1983).","journal-title":"JOURNAL OF INFECTIOUS DISEASES"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1093\/infdis\/148.6.1108","volume":"148","year":"1983","unstructured":"CURRENT, W.L., DEVELOPMENT OF HUMAN AND CALF CRYPTOSPORIDIUM IN CHICKEN EMBRYOS, JOURNAL OF INFECTIOUS DISEASES 148: 1108 (1983).","journal-title":"JOURNAL OF INFECTIOUS DISEASES"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1056\/NEJM198305263082102","volume":"308","year":"1983","unstructured":"CURRENT, W.L., HUMAN CRYPTOSPORIDIOSIS IN IMMUNOCOMPETENT AND IMMUNODEFICIENT PERSONS - STUDIES OF AN OUTBREAK AND EXPERIMENTAL TRANSMISSION, NEW ENGLAND JOURNAL OF MEDICINE 308: 1252 (1983).","journal-title":"NEW ENGLAND JOURNAL OF MEDICINE"},{"key":"e_1_2_1_5_1","unstructured":"Current W. 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