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Competition of FE for binding sites is observed with estrogens, but not with progestins, androgens, or glucocorticosteroids, indicating the specificity of FE binding. In contrast to other estrogen receptor assays, this new technique requires a small sample size (about 5000 cells) and permits the assessment of heterogeneity in estrogen receptor expression among tumor cells.<\/jats:p>","DOI":"10.1126\/science.6719116","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T15:41:59Z","timestamp":1160062919000},"page":"876-879","source":"Crossref","is-referenced-by-count":38,"title":["Estrogen Receptor Analysis by Flow Cytometry"],"prefix":"10.1126","volume":"224","author":[{"given":"Nguyen T.","family":"Van","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Louisville, Louisville, Kentucky 40232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Raber","sequence":"additional","affiliation":[{"name":"University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Department of Hematology, Houston 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George H.","family":"Barrows","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Louisville, Louisville, Kentucky 40232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Barlogie","sequence":"additional","affiliation":[{"name":"University of Texas System Cancer Center, M. D. 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