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The drug, which is remarkably nontoxic, was effective when administered in drinking water or by intubation. The ability of the compound to inhibit ornithine decarboxylase in vitro was demonstrated by the reduced amounts of putrescine synthesized from tritiated ornithine in\n            <jats:italic>Trypanosoma bruce<\/jats:italic>\n            suspensions. These observations direct attention to polyamine metabolism as a target for chemotherapy of parasitic diseases.\n          <\/jats:p>","DOI":"10.1126\/science.6775372","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T17:45:58Z","timestamp":1160070358000},"page":"332-334","source":"Crossref","is-referenced-by-count":318,"title":["Polyamine Metabolism: A Potential Therapeutic Target in Trypanosomes"],"prefix":"10.1126","volume":"210","author":[{"given":"C. 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