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Calcium also has a synergistic effect on melarsoprol, the only drug available for treating sleeping sickness patients with central nervous system involvement, and the concentration of calcium has been reported to be depressed in the serum of experimentally infected animals.\n          <\/jats:p>","DOI":"10.1126\/science.6805075","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T14:30:32Z","timestamp":1160058632000},"page":"1321-1323","source":"Crossref","is-referenced-by-count":20,"title":["Role of Calcium in Trypanocidal Drug Action"],"prefix":"10.1126","volume":"216","author":[{"suffix":"Jr.","given":"AB","family":"Clarkson","sequence":"first","affiliation":[{"name":"Division of Parasitology, New York University School of Medicine, New York 10016"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BO","family":"Amole","sequence":"additional","affiliation":[{"name":"Division of Parasitology, New York University School of Medicine, New York 10016"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0014-4894(81)90050-3","volume":"51","year":"1981","unstructured":"AMOLE, B.O., TRYPANOSOMA-BRUCEI - HOST-PARASITE INTERACTION IN PARASITE DESTRUCTION BY SALICYLHYDROXAMIC ACID AND GLYCEROL IN MICE, EXPERIMENTAL PARASITOLOGY 51: 133 (1981).","journal-title":"EXPERIMENTAL PARASITOLOGY"},{"key":"e_1_2_1_2_1","first-page":"23","volume":"35","year":"1978","unstructured":"BROHN, F.H., QUANTITATIVE EFFECTS OF SALYCYLHYDROXAMIC ACID AND GLYCEROL ON TRYPANOSOMA-BRUCEI GLYCOLYSIS INVITRO AND INVIVO, ACTA TROPICA 35: 23 (1978).","journal-title":"ACTA TROPICA"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0166-6851(80)90062-6","volume":"1","year":"1980","unstructured":"BROHN, F.H., TRYPANOSOMA-BRUCEI-BRUCEI - PATTERNS OF GLYCOLYSIS AT 37-DEGREES-C INVITRO, MOLECULAR AND BIOCHEMICAL PARASITOLOGY 1: 291 (1980).","journal-title":"MOLECULAR AND BIOCHEMICAL PARASITOLOGY"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"4809","DOI":"10.1016\/S0021-9258(17)30461-1","volume":"253","year":"1978","unstructured":"CHIEN, K.R., ACCELERATED PHOSPHOLIPID DEGRADATION AND ASSOCIATED MEMBRANE DYSFUNCTION IN IRREVERSIBLE, ISCHEMIC LIVER-CELL INJURY, JOURNAL OF BIOLOGICAL CHEMISTRY 253: 4809 (1978).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.986688"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/282613a0","volume":"282","year":"1979","unstructured":"DHONDT, J, CA2+ IS ESSENTIAL COFACTOR FOR TRYPANOCIDAL ACTIVITY OF NORMAL HUMAN-SERUM, NATURE 282: 613 (1979).","journal-title":"NATURE"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1017\/S0031182000046059","volume":"66","year":"1973","unstructured":"GOODWIN, L.G., TISSUE FLUID IN RABBITS INFECTED WITH TRYPANOSOMA-BRUCEI (TRYPANOZOON) BRUCEI, PARASITOLOGY 66: 499 (1973).","journal-title":"PARASITOLOGY"},{"key":"e_1_2_1_8_1","first-page":"269","year":"1980","unstructured":"Parfitt, A. 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