{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:54:24Z","timestamp":1790880864153,"version":"4.1.0"},"reference-count":30,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4572","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1982,11,5]]},"abstract":"<jats:p>\n                    A 44 amino acid peptide with growth hormone-releasing activity has been isolated from a human tumor of the pancreas that had caused acromegaly. The primary structure of the tumor-derived peptide is H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH\n                    <jats:sub>2<\/jats:sub>\n                    . The synthetic replicate has full biological activity in vitro and in vivo specifically to stimulate the secretion of immunoreactive growth hormone. The tumor-derived peptide is identical in biological activity and similar in physicochemical properties to the still uncharacterized growth hormone-releasing factor present in extracts of hypothalamic tissues.\n                  <\/jats:p>","DOI":"10.1126\/science.6812220","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T14:30:32Z","timestamp":1160058632000},"page":"585-587","source":"Crossref","is-referenced-by-count":945,"title":["Growth Hormone-Releasing Factor from a Human Pancreatic Tumor That Caused Acromegaly"],"prefix":"10.1126","volume":"218","author":[{"given":"Roger","family":"Guillemin","sequence":"first","affiliation":[{"name":"Laboratories for Neuroendocrinology, Salk Institute for Biological Studies, La Jolla, California 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Brazeau","sequence":"additional","affiliation":[{"name":"Laboratories for Neuroendocrinology, Salk Institute for Biological Studies, La Jolla, California 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bohlen","sequence":"additional","affiliation":[{"name":"Laboratories for Neuroendocrinology, Salk Institute for Biological Studies, La Jolla, California 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick","family":"Esch","sequence":"additional","affiliation":[{"name":"Laboratories for Neuroendocrinology, Salk Institute for Biological Studies, La Jolla, California 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Ling","sequence":"additional","affiliation":[{"name":"Laboratories for Neuroendocrinology, Salk Institute for Biological Studies, La Jolla, California 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B.","family":"Wehrenberg","sequence":"additional","affiliation":[{"name":"Laboratories for Neuroendocrinology, Salk Institute for Biological Studies, La Jolla, 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ACROMEGALY BY OPERATIVE REMOVAL OF AN ISLET CELL TUMOR OF PANCREAS, AMERICAN JOURNAL OF MEDICINE 64: 874 (1978).","journal-title":"AMERICAN JOURNAL OF MEDICINE"},{"key":"e_1_2_1_9_1","unstructured":"DELEAN A DHEW PUBLICATION E 97 (1977)."},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1210\/endo-74-3-408","volume":"74","year":"1964","unstructured":"DEUBEN, R.R., STIMULATION OF PITUITARY GROWTH HORMONE RELEASE BY HYPOTHALAMIC EXTRACT IN VITRO, ENDOCRINOLOGY 74: 408 (1964).","journal-title":"ENDOCRINOLOGY"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1172\/JCI109658","volume":"65","year":"1980","unstructured":"FROHMAN, L.A., PARTIAL-PURIFICATION AND CHARACTERIZATION OF A PEPTIDE WITH GROWTH HORMONE-RELEASING ACTIVITY FROM EXTRAPITUITARY TUMORS IN PATIENTS WITH ACROMEGALY, JOURNAL OF CLINICAL INVESTIGATION 65: 43 (1980).","journal-title":"JOURNAL OF CLINICAL 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