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Treatment of neonatal rat pups with cyproheptadine, a serotonin antagonist that suppresses growth hormone secretion, resulted in a significant decline in both serum growth hormone concentration and brain ornithine decarboxylase activity. These findings suggest that maternal deprivation elicits a specific suppression of growth hormone release which mediates the decrease in ornithine decarboxylase activity. The study is consistent with clinical findings of impaired growth hormone \"responsivity\" in human maternal deprivation syndrome.<\/jats:p>","DOI":"10.1126\/science.684424","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T16:35:25Z","timestamp":1160066125000},"page":"1034-1036","source":"Crossref","is-referenced-by-count":132,"title":["Selective Depression of Serum Growth Hormone During Maternal Deprivation in Rat Pups"],"prefix":"10.1126","volume":"201","author":[{"given":"C. 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