{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:07:44Z","timestamp":1790845664454,"version":"4.1.0"},"reference-count":27,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4605","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1983,7]]},"abstract":"<jats:p>A low molecular weight, lipophilic, copper coordination complex with superoxide dismutase-mimetic activity inhibited biochemical and biological actions of a tumor promoter in mouse epidermis. Such inhibitory effects implicate reactive oxygen species in the tumor promotion process.<\/jats:p>","DOI":"10.1126\/science.6857269","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T18:37:18Z","timestamp":1160073438000},"page":"75-77","source":"Crossref","is-referenced-by-count":182,"title":["Inhibition of Tumor Promotion by a Biomimetic Superoxide Dismutase"],"prefix":"10.1126","volume":"221","author":[{"given":"Thomas W.","family":"Kensler","sequence":"first","affiliation":[{"name":"Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M.","family":"Bush","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter J.","family":"Kozumbo","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6276978"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3109\/10408448009037493","volume":"8","year":"1980","unstructured":"BLUMBERG, P.M., INVITRO STUDIES ON THE MODE OF ACTION OF THE PHORBOL ESTERS, POTENT TUMOR PROMOTERS .1., CRC CRITICAL REVIEWS IN TOXICOLOGY 8: 153 (1980).","journal-title":"CRC CRITICAL REVIEWS IN TOXICOLOGY"},{"key":"e_1_2_1_3_1","first-page":"1","year":"1980","unstructured":"BORS, W, BIOL CLIN ASPECTS SU 1 (1980).","journal-title":"BIOL CLIN ASPECTS SU"},{"key":"e_1_2_1_4_1","first-page":"419","volume":"2","year":"1974","unstructured":"BOUTWELL, R.K., CRC CRIT R TOXICOL 2: 419 (1974).","journal-title":"CRC CRIT R TOXICOL"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/0014-5793(74)80428-X","volume":"47","year":"1974","unstructured":"BRIGELIUS, R, SUPEROXIDE-DISMUTASE ACTIVITY OF LOW-MOLECULAR WEIGHT CU2+-CHELATES STUDIED BY PULSE-RADIOLYSIS, FEBS LETTERS 47: 72 (1974).","journal-title":"FEBS LETTERS"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0041-008X(73)90252-4","volume":"26","year":"1973","unstructured":"CARSON, S, SAFETY TESTS OF ORGOTEIN, AN ANTIINFLAMMATORY PROTEIN, TOXICOLOGY AND APPLIED PHARMACOLOGY 26: 184 (1973).","journal-title":"TOXICOLOGY AND APPLIED PHARMACOLOGY"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/0006-291X(76)90930-X","volume":"69","year":"1976","unstructured":"DEALVARE, L.R., MECHANISM OF SUPEROXIDE ANION SCAVENGING REACTION BY BIS-(SALICYLATO)-COPPER(II) COMPLEX, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 69: 687 (1976).","journal-title":"BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-230X(08)60360-7","volume":"32","year":"1980","unstructured":"DIAMOND, L, ADVANCES IN CANCER RESEARCH 32: 1 (1980).","journal-title":"ADVANCES IN CANCER RESEARCH"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/293144a0","volume":"293","year":"1981","unstructured":"EMERIT, I, TUMOR PROMOTER PHORBOL-12-MYRISTATE-13-ACETATE INDUCES CHROMOSOMAL DAMAGE VIA INDIRECT ACTION, NATURE 293: 144 (1981).","journal-title":"NATURE"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/248347a0","volume":"248","year":"1974","unstructured":"ESTENSEN, R.D., SPECIFIC DEGRANULATION OF HUMAN POLYMORPHONUCLEAR LEUKOCYTES, NATURE 248: 347 (1974).","journal-title":"NATURE"},{"key":"e_1_2_1_11_1","first-page":"250","year":"1981","unstructured":"FRIDOVICH, I, OXYGEN LIVING PROCES 250 (1981).","journal-title":"OXYGEN LIVING PROCES"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/0006-291X(79)91487-6","volume":"88","year":"1979","unstructured":"GOLDSTEIN, B.D., PROTEASE INHIBITORS ANTAGONIZE THE ACTIVATION OF POLYMORPHONUCLEAR LEUKOCYTE OXYGEN-CONSUMPTION, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 88: 854 (1979).","journal-title":"BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/0006-2952(82)90462-2","volume":"31","year":"1982","unstructured":"HOFFMAN, M, EFFECT OF CYCLOOXYGENASE INHIBITORS AND PROTEASE INHIBITORS ON PHORBOL-INDUCED STIMULATION OF OXYGEN-CONSUMPTION AND SUPEROXIDE PRODUCTION BY RAT PULMONARY MACROPHAGES, BIOCHEMICAL PHARMACOLOGY 31: 775 (1982).","journal-title":"BIOCHEMICAL PHARMACOLOGY"},{"key":"e_1_2_1_14_1","first-page":"216","volume":"41","year":"1981","unstructured":"KENSLER, T.W., INHIBITION OF PHORBOL ESTER-STIMULATED CHEMI-LUMINESCENCE IN HUMAN POLYMORPHONUCLEAR LEUKOCYTES BY RETINOIC ACID AND 5,6-EPOXYRETINOIC ACID, CANCER RESEARCH 41: 216 (1981).","journal-title":"CANCER RESEARCH"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/1523-1747.ep12510444","volume":"79","year":"1982","unstructured":"KLEINSZANTO, AJP, EFFECTS OF PEROXIDES ON RODENT SKIN - EPIDERMAL HYPERPLASIA AND TUMOR PROMOTION, JOURNAL OF INVESTIGATIVE DERMATOLOGY 79: 30 (1982).","journal-title":"JOURNAL OF INVESTIGATIVE DERMATOLOGY"},{"key":"e_1_2_1_16_1","first-page":"2555","volume":"43","year":"1983","unstructured":"KOZUMBO, W.J., INHIBITION BY 2(3)-TERT-BUTYL-4-HYDROXYANISOLE AND OTHER ANTI-OXIDANT OF EPIDERMAL ORNITHINE DECARBOXYLASE ACTIVITY INDUCED BY 12-O-TETRADECANOYLPHORBOL-13-ACETATE, CANCER RESEARCH 43: 2555 (1983).","journal-title":"CANCER RESEARCH"},{"key":"e_1_2_1_17_1","unstructured":"KOZUMBO W.J. THESIS U IOWA (1979)."},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1093\/jnci\/66.6.1077","volume":"66","year":"1981","unstructured":"LEUTHAUSER, SWC, ANTI-TUMOR EFFECT OF A COPPER COORDINATION COMPOUND WITH SUPEROXIDE DISMUTASE-LIKE ACTIVITY, JOURNAL OF THE NATIONAL CANCER INSTITUTE 66: 1077 (1981).","journal-title":"JOURNAL OF THE NATIONAL CANCER INSTITUTE"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0306-9877(81)90018-9","volume":"7","year":"1981","unstructured":"OBERLEY, L.W., CELL-DIVISION IN NORMAL AND TRANSFORMED-CELLS - THE POSSIBLE ROLE OF SUPEROXIDE AND HYDROGEN-PEROXIDE, MEDICAL HYPOTHESES 7: 21 (1981).","journal-title":"MEDICAL HYPOTHESES"},{"key":"e_1_2_1_20_1","first-page":"2426","volume":"35","year":"1975","unstructured":"OBRIEN, T.G., INDUCTION OF POLYAMINE-BIOSYNTHETIC ENZYMES IN MOUSE EPIDERMIS AND THEIR SPECIFICITY FOR TUMOR PROMOTION, CANCER RESEARCH 35: 2426 (1975).","journal-title":"CANCER RESEARCH"},{"key":"e_1_2_1_21_1","first-page":"19","volume":"7","year":"1982","unstructured":"SLAGA, T.J., CARCINOGENESIS 7: 19 (1982).","journal-title":"CARCINOGENESIS"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1126\/science.6791284","volume":"213","year":"1981","unstructured":"SLAGA, T.J., SKIN TUMOR-PROMOTING ACTIVITY OF BENZOYL PEROXIDE, A WIDELY USED FREE RADICAL-GENERATING COMPOUND, SCIENCE 213: 1023 (1981).","journal-title":"SCIENCE"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1093\/carcin\/2.11.1141","volume":"2","year":"1981","unstructured":"SOLANKI, V, DIMINUTION OF MOUSE EPIDERMAL SUPEROXIDE-DISMUTASE AND CATALASE ACTIVITIES BY TUMOR PROMOTERS, CARCINOGENESIS 2: 1141 (1981).","journal-title":"CARCINOGENESIS"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1021\/jm00223a024","volume":"19","year":"1976","unstructured":"SORENSON, JRJ, COPPER CHELATES AS POSSIBLE ACTIVE FORMS OF ANTIARTHRITIC AGENTS, JOURNAL OF MEDICINAL CHEMISTRY 19: 135 (1976).","journal-title":"JOURNAL OF MEDICINAL CHEMISTRY"},{"key":"e_1_2_1_25_1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1042\/bj1780381","volume":"178","year":"1979","unstructured":"TAYLOR, W.M., STIMULATION OF GLUCOSE-TRANSPORT IN RAT ADIPOCYTES BY INSULIN, ADENOSINE, NICOTINIC-ACID AND HYDROGEN-PEROXIDE - ROLE OF ADENOSINE 3'-5'-CYCLIC MONOPHOSPHATE, BIOCHEMICAL JOURNAL 178: 381 (1979).","journal-title":"BIOCHEMICAL JOURNAL"},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","first-page":"7304","DOI":"10.1016\/S0021-9258(17)32850-8","volume":"251","year":"1976","unstructured":"WHITE, A.A., ACTIVATION OF SOLUBLE GUANYLATE CYCLASE FROM RAT LUNG BY INCUBATION OR BY HYDROGEN-PEROXIDE, JOURNAL OF BIOLOGICAL CHEMISTRY 251: 7304 (1976).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_27_1","first-page":"336","year":"1980","unstructured":"YOUNES, M, BIOL CLIN ASPECTS SU 336 (1980).","journal-title":"BIOL CLIN ASPECTS SU"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.6857269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T22:34:38Z","timestamp":1705271678000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.6857269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,7]]},"references-count":27,"journal-issue":{"issue":"4605","published-print":{"date-parts":[[1983,7]]}},"alternative-id":["10.1126\/science.6857269"],"URL":"https:\/\/doi.org\/10.1126\/science.6857269","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,7]]}}}