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Zinc-protoporphyrin at doses up to 50-fold greater than the effective dose of tin-protoporphyrin did not prevent the immediate increases in tissue heme oxygenase activities and in serum bilirubin levels that occur postnatally. Studies in vitro with microsomal heme oxygenase in human spleen indicate that tin-protoporphyrin is a potent competitive inhibitor of the oxidation of heme to bile pigment in this tissue.<\/jats:p>","DOI":"10.1126\/science.6896768","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T18:30:32Z","timestamp":1160073032000},"page":"1250-1252","source":"Crossref","is-referenced-by-count":71,"title":["Chemoprevention of Neonatal Jaundice: Potency of Tin-Protoporphyrin in an Animal Model"],"prefix":"10.1126","volume":"217","author":[{"given":"George S.","family":"Drummond","sequence":"first","affiliation":[{"name":"Rockefeller University Hospital, New York 1002"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attallah","family":"Kappas","sequence":"additional","affiliation":[{"name":"Rockefeller University Hospital, New York 1002"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","unstructured":"ANDERSON K.E. unpublished data."},{"key":"e_1_2_1_2_1","first-page":"2725","volume":"68","year":"1971","unstructured":"BONKOWSKY, H.L., REPRESSION OF OVERPRODUCTION OF PORPHYRIN PRECURSORS IN ACUTE INTERMITTENT PORPHYRIA BY INTRAVENOUS INFUSIONS OF HEMATIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 68: 2725 (1971).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_3_1","first-page":"6466","volume":"78","year":"1981","unstructured":"Drummond, G. 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