{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T20:44:28Z","timestamp":1784925868329,"version":"3.55.0"},"reference-count":17,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4426","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1980,1,4]]},"abstract":"<jats:p>\n            In concentrates of water produced in a laboratory simulation of a drinking water treatment process, direct-acting, nonvolatile mutagens were readily detected by means of the Ames\n            <jats:italic>Salmonella<\/jats:italic>\n            test. The mutagens were shown to be produced by the chlorination process. Treatment of the water with chloramine resulted in less mutagenic activity than treatment with free chlorine. Dechlorination of drinking water with sulfite sharply reduced the mutagenic activity. Treatment with sulfur dioxide is proposed as an effective, inexpensive method of reducing the direct-acting mutagenic activity of drinking water and of aqueous industrial effluents.\n          <\/jats:p>","DOI":"10.1126\/science.6985746","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T17:45:58Z","timestamp":1160070358000},"page":"90-92","source":"Crossref","is-referenced-by-count":130,"title":["Nonvolatile Mutagens in Drinking Water: Production by Chlorination and Destruction by Sulfite"],"prefix":"10.1126","volume":"207","author":[{"given":"Albert M.","family":"Cheh","sequence":"first","affiliation":[{"name":"Gray Freshwater Biological Institute, University of Minnesota, Navarre 55392"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Skochdopole","sequence":"additional","affiliation":[{"name":"Gray Freshwater Biological Institute, University of Minnesota, Navarre 55392"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Koski","sequence":"additional","affiliation":[{"name":"Gray Freshwater Biological Institute, University of Minnesota, Navarre 55392"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Cole","sequence":"additional","affiliation":[{"name":"Gray Freshwater Biological Institute, University of Minnesota, Navarre 55392"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","unstructured":"Committee on Safe Drinking Water of the National Research Council Drinking Water and Health (1977)."},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0165-1161(75)90046-1","volume":"31","year":"1975","unstructured":"AMES, B.N., METHODS FOR DETECTING CARCINOGENS AND MUTAGENS WITH SALMONELLA-MAMMALIAN-MICROSOME MUTAGENICITY TEST, MUTATION RESEARCH 31: 347 (1975).","journal-title":"MUTATION RESEARCH"},{"key":"e_1_2_1_3_1","first-page":"454","volume":"80","year":"1977","unstructured":"ANDER, P, SVENSK PAPPERSTIDNING-NORDISK CELLULOSA 80: 454 (1977).","journal-title":"SVENSK PAPPERSTIDNING-NORDISK CELLULOSA"},{"key":"e_1_2_1_4_1","first-page":"223","volume":"2","year":"1978","unstructured":"Bean, R. 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