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There is also evidence that multiple hormones from several endocrine glands are required to act in concert with androgens to produce and maintain their effects. Although many of the consequences of sexual dimorphism, such as body size and strength, have been evident for centuries, other differences between males and females such as disease incidence, response to drugs and toxins, and the metabolism and assimilation of dietary constituents have only recently been discovered.<\/jats:p>","DOI":"10.1126\/science.7010603","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T13:45:58Z","timestamp":1160055958000},"page":"1285-1294","source":"Crossref","is-referenced-by-count":283,"title":["Testosterone: A Major Determinant of Extragenital Sexual Dimorphism"],"prefix":"10.1126","volume":"211","author":[{"given":"C. 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