{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T22:15:22Z","timestamp":1726438522498},"reference-count":18,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4541","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1982,4,2]]},"abstract":"<jats:p>Biological characteristics were assessed in GR mouse mammary tumors during 22 serial transplantations. Although unidirectional progression from hormone dependency to independency was observed, other biological markers such as progesterone receptors, polyploid frequency, and thymidine kinase activity demonstrated cyclic phenomena every fourth to sixth transplant generation, suggesting the continued presence of regulatory mechanisms among various cell subpopulations.<\/jats:p>","DOI":"10.1126\/science.7063874","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T14:30:32Z","timestamp":1160058632000},"page":"68-70","source":"Crossref","is-referenced-by-count":14,"title":["Cyclic Biological Expression in Mouse Mammary Tumors"],"prefix":"10.1126","volume":"216","author":[{"given":"David T.","family":"Kiang","sequence":"first","affiliation":[{"name":"Section of Medical Oncology, Department of Medicine, University of Minnesota Medical School, Minneapolis 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"King","sequence":"additional","affiliation":[{"name":"Section of Medical Oncology, Department of Medicine, University of Minnesota Medical School, Minneapolis 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Section of Medical Oncology, Department of Medicine, University of Minnesota Medical School, Minneapolis 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. J.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Section of Medical Oncology, Department of Medicine, University of Minnesota Medical School, Minneapolis 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Wang","sequence":"additional","affiliation":[{"name":"Section of Cytogenetics, Department of Pathology and Laboratory Medicine, University of Minnesota Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1093\/jnci\/56.5.909","volume":"56","year":"1976","unstructured":"ATKIN, N.B., PROGNOSTIC SIGNIFICANCE OF PLOIDY LEVEL IN HUMAN TUMORS .1. CARCINOMA OF UTERUS, JOURNAL OF THE NATIONAL CANCER INSTITUTE 56: 909 (1976).","journal-title":"JOURNAL OF THE NATIONAL CANCER INSTITUTE"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0926-6569(63)90218-9","volume":"67","year":"1963","unstructured":"BREITMAN, T.R., FEEDBACK INHIBITION OF THYMIDINE KINASE, BIOCHIMICA ET BIOPHYSICA ACTA 67: 153 (1963).","journal-title":"BIOCHIMICA ET BIOPHYSICA ACTA"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/0006-2952(79)90647-6","volume":"28","year":"1979","unstructured":"CALABRESI, P, CLINICAL AND PHARMACOLOGICAL IMPLICATIONS OF CANCER CELL-DIFFERENTIATION AND HETEROGENEITY, BIOCHEMICAL PHARMACOLOGY 28: 1933 (1979).","journal-title":"BIOCHEMICAL PHARMACOLOGY"},{"key":"e_1_2_1_4_1","unstructured":"FOULDS L NEOPLASTIC DEV 1 (1969)."},{"key":"e_1_2_1_5_1","unstructured":"FOULDS L NEOPLASTIC DEV 2 (1975)."},{"key":"e_1_2_1_6_1","first-page":"2492","volume":"38","year":"1978","unstructured":"HAGER, J.C., INFLUENCE OF SERIAL TRANSPLANTATION ON IMMUNOLOGICAL-CLINICAL CORRELATES OF BALB-CFC3H MOUSE MAMMARY-TUMORS, CANCER RESEARCH 38: 2492 (1978).","journal-title":"CANCER RESEARCH"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1056\/NEJM197812142992403","volume":"299","year":"1978","unstructured":"KIANG, D.T., ESTROGEN RECEPTORS AND RESPONSES TO CHEMOTHERAPY AND HORMONAL THERAPY IN ADVANCED BREAST-CANCER, NEW ENGLAND JOURNAL OF MEDICINE 299: 1330 (1978).","journal-title":"NEW ENGLAND JOURNAL OF MEDICINE"},{"key":"e_1_2_1_8_1","first-page":"2068","volume":"35","year":"1975","unstructured":"KIM, U, PROGRESSION FROM HORMONE DEPENDENCE TO AUTONOMY IN MAMMARY-TUMORS AS AN INVIVO MANIFESTATION OF SEQUENTIAL CLONAL SELECTION, CANCER RESEARCH 35: 2068 (1975).","journal-title":"CANCER RESEARCH"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/BF01744997","volume":"11","year":"1976","unstructured":"KIT, S, THYMIDINE KINASE, DNA-SYNTHESIS AND CANCER, MOLECULAR AND CELLULAR BIOCHEMISTRY 11: 161 (1976).","journal-title":"MOLECULAR AND CELLULAR BIOCHEMISTRY"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1111\/j.1749-6632.1956.tb50894.x","volume":"63","year":"1956","unstructured":"MAKINO, S, FURTHER EVIDENCE FAVORING THE CONCEPT OF THE STEM CELL IN ASCITES TUMORS OF RATS, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 63: 818 (1956).","journal-title":"ANNALS OF THE NEW YORK ACADEMY OF SCIENCES"},{"key":"e_1_2_1_11_1","first-page":"1890","volume":"40","year":"1980","unstructured":"MEYER, J.S., RELATIONSHIPS OF S-PHASE FRACTION OF BREAST-CARCINOMA IN RELAPSE TO DURATION OF REMISSION, ESTROGEN-RECEPTOR CONTENT, THERAPEUTIC RESPONSIVENESS, AND DURATION OF SURVIVAL, CANCER RESEARCH 40: 1890 (1980).","journal-title":"CANCER RESEARCH"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.959840"},{"key":"e_1_2_1_13_1","first-page":"227","year":"1977","unstructured":"PHILIBERT, D, PROGESTERONE RECEPTO: 227 (1977).","journal-title":"PROGESTERONE RECEPTO"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/1097-0142(197908)44:2<665::AID-CNCR2820440237>3.0.CO;2-N","volume":"44","year":"1979","unstructured":"SILVESTRINI, R, RELATIONSHIP BETWEEN PROLIFERATIVE ACTIVITY AND ESTROGEN RECEPTORS IN BREAST-CANCER, CANCER 44: 665 (1979).","journal-title":"CANCER"},{"key":"e_1_2_1_15_1","first-page":"509","volume":"560","year":"1979","unstructured":"SLUYSER, M, HORMONE RECEPTORS IN MOUSE MAMMARY-TUMORS, BIOCHIMICA ET BIOPHYSICA ACTA 560: 509 (1979).","journal-title":"BIOCHIMICA ET BIOPHYSICA ACTA"},{"key":"e_1_2_1_16_1","first-page":"3253","volume":"34","year":"1974","unstructured":"SLUYSER, M, ESTROGEN-RECEPTOR CONTENT AND HORMONE-RESPONSIVE GROWTH OF MOUSE MAMMARY-TUMORS, CANCER RESEARCH 34: 3253 (1974).","journal-title":"CANCER RESEARCH"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/263386a0","volume":"263","year":"1976","unstructured":"SLUYSER, M, SEX-HORMONE RECEPTORS IN MAMMARY-TUMORS OF GR MICE, NATURE 263: 386 (1976).","journal-title":"NATURE"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1002\/1097-0142(197205)29:5<1401::AID-CNCR2820290543>3.0.CO;2-0","volume":"29","year":"1972","unstructured":"SPOONER, M.E., CHROMOSOME CONSTITUTION OF TRANSITIONAL CELL-CARCINOMA OF URINARY-BLADDER, CANCER 29: 1401 (1972).","journal-title":"CANCER"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.7063874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T18:39:35Z","timestamp":1705257575000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.7063874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,4,2]]},"references-count":18,"journal-issue":{"issue":"4541","published-print":{"date-parts":[[1982,4,2]]}},"alternative-id":["10.1126\/science.7063874"],"URL":"https:\/\/doi.org\/10.1126\/science.7063874","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"type":"print","value":"0036-8075"},{"type":"electronic","value":"1095-9203"}],"subject":[],"published":{"date-parts":[[1982,4,2]]}}}