{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:40:40Z","timestamp":1790941240488,"version":"4.1.0"},"reference-count":24,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4371","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1978,12]]},"abstract":"<jats:p>\n            Small doses of the opiate antagonist naloxone selectively abolished overeating in genetically obese mice (\n            <jats:italic>ob<\/jats:italic>\n            \/\n            <jats:italic>ob<\/jats:italic>\n            ) and rats (\n            <jats:italic>fa<\/jats:italic>\n            \/\n            <jats:italic>fa<\/jats:italic>\n            ). Elevated concentrations of the naturally occurring opiate \u03b2-endorphin were found in the pituitaries of both obese species and in the blood plasma of the obese rats. Brain levels of \u03b2-endorphin and Leu-enkephalin were unchanged. These data suggest that excess pituitary \u03b2-endorphin may play a role in the development of the overeating and obesity syndrome.\n          <\/jats:p>","DOI":"10.1126\/science.715455","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T16:35:25Z","timestamp":1160066125000},"page":"988-991","source":"Crossref","is-referenced-by-count":418,"title":["\u03b2-Endorphin Is Associated with Overeating in Genetically Obese Mice (\n            <i>ob<\/i>\n            \/\n            <i>ob<\/i>\n            ) and Rats (\n            <i>fa<\/i>\n            \/\n            <i>fa<\/i>\n            )"],"prefix":"10.1126","volume":"202","author":[{"given":"David L.","family":"Margules","sequence":"first","affiliation":[{"name":"Department of Psychology, Temple University, Philadelphia, Pennsylvania 19122"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Moisset","sequence":"additional","affiliation":[{"name":"Department of Psychology, Temple University, Philadelphia, Pennsylvania 19122"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Psychology, Tufts University, Medford, Massachusetts 02155"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruo","family":"Shibuya","sequence":"additional","affiliation":[{"name":"Section on Biochemistry and Pharmacology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20014"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candace B.","family":"Pert","sequence":"additional","affiliation":[{"name":"Section on Biochemistry and Pharmacology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20014"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"4972","volume":"75","year":"1978","unstructured":"Allen, R. 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