{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T19:43:07Z","timestamp":1769283787499,"version":"3.49.0"},"reference-count":17,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4451","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1980,6,27]]},"abstract":"<jats:p>\n            Three Siamese cats were found to have a progressive neurological disease that became obvious when they were 4 to 5 months of age. Their brains contained an excess of G\n            <jats:italic>M2<\/jats:italic>\n            and G\n            <jats:italic>M3<\/jats:italic>\n            gangliosides, and their livers a nine- to tenfold excess of sphingomyelin and cholesterol. A total deficiency of lysosomal (\n            <jats:italic>p<\/jats:italic>\n            H 5.0) sphingomyelinase was found in the leukocytes, liver, and brain of the cats, although the activity of the microsomal (\n            <jats:italic>p<\/jats:italic>\n            H 7.4, magnesium-dependent) sphingomyelinase was normal in brain. These cats appear to have a genetic disease identical to Niemann-Pick disease type A.\n          <\/jats:p>","DOI":"10.1126\/science.7189903","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T17:45:58Z","timestamp":1160070358000},"page":"1471-1473","source":"Crossref","is-referenced-by-count":54,"title":["Niemann-Pick Disease: A Genetic Model in Siamese Cats"],"prefix":"10.1126","volume":"208","author":[{"given":"David A.","family":"Wenger","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Colorado Health Sciences Center, Denver 80262"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Sattler","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Colorado Health Sciences Center, Denver 80262"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tooru","family":"Kudoh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Colorado Health Sciences Center, Denver 80262"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley P.","family":"Snyder","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Veterinary Medicine, Colorado State University, Fort Collins 80523"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard S.","family":"Kingston","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Veterinary Medicine, Colorado State University, Fort Collins 80523"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.174.4011.838"},{"key":"e_1_2_1_2_1","first-page":"366","volume":"55","year":"1966","unstructured":"BRADY, R.O., METABOLISM OF SPHINGOMYELIN .2. EVIDENCE OF AN ENZYMATIC DEFICIENCY IN NIEMANN-PICK DISEASE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 55: 366 (1966).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0009-8981(73)90363-X","volume":"48","year":"1973","unstructured":"BRUNNGRABER, E.G., ALTERED LEVELS OF TISSUE GLYCOPROTEINS, GANGLIOSIDES, GLYCOSAMINOGLYCANS AND LIPIDS IN NIEMANN-PICKS DISEASE, CLINICA CHIMICA ACTA 48: 173 (1973).","journal-title":"CLINICA CHIMICA ACTA"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1177\/030098587901600504","volume":"16","year":"1979","unstructured":"BUNDZA, A, NIEMANN-PICK DISEASE IN A POODLE DOG, VETERINARY PATHOLOGY 16: 530 (1979).","journal-title":"VETERINARY PATHOLOGY"},{"key":"e_1_2_1_5_1","first-page":"616","volume":"156","year":"1970","unstructured":"CHRISP, C.E., LIPID STORAGE DISEASE IN A SIAMESE CAT, JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION 156: 616 (1970).","journal-title":"JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.404709"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1471-4159.1961.tb13499.x","volume":"7","year":"1961","unstructured":"CROCKER, A.C., CEREBRAL DEFECT IN TAY-SACHS DISEASE AND NIEMANN-PICK DISEASE, JOURNAL OF NEUROCHEMISTRY 7: 69 (1961).","journal-title":"JOURNAL OF NEUROCHEMISTRY"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/j.1471-4159.1978.tb02671.x","volume":"31","year":"1978","unstructured":"GATT, S, NIEMANN PICK DISEASE - PRESENCE OF MAGNESIUM-DEPENDENT SPHINGOMYELINASE IN BRAIN OF INFANTILE FORM OF DISEASE, JOURNAL OF NEUROCHEMISTRY 31: 547 (1978).","journal-title":"JOURNAL OF NEUROCHEMISTRY"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.144321"},{"key":"e_1_2_1_10_1","unstructured":"KINGSTON R.S. 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