{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T17:06:30Z","timestamp":1767373590377},"reference-count":14,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4498","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1981,5,29]]},"abstract":"<jats:p>Phencyclidine (PCP), lysergic acid diethylamide (LSD), and mescaline produced potent contractile responses on isolated basilar and middle cerebral arteries, where, in terms of potency, LSD &gt; mescaline &gt; PCP. All three drugs produced cerebrovasospasm in a concentration range which parallels that needed for their psychotomimetic and intoxicating actions. Specific receptors for PCP, which subserve contraction and differ from those for LSD and mescaline, are found in cerebral arteries. Concentrations of PCP that produced near-maximum contractile responses on cerebral arteries were similar to those in the blood and brain of human subjects who had died from PCP overdoses. A specific calcium antagonist, verapamil, readily prevented (and reversed) PCP-induced vasospasm. This study provides direct evidence for PCP receptors in cerebral blood vessels, the biologic action of which can be reversed by a calcium antagonist; the clinical use of the latter could prove invaluable in treating PCP-intoxicated victims.<\/jats:p>","DOI":"10.1126\/science.7195070","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T17:45:58Z","timestamp":1160070358000},"page":"1051-1052","source":"Crossref","is-referenced-by-count":69,"title":["Phencyclidine, Lysergic Acid Diethylamide, and Mescaline: Cerebral Artery Spasms and Hallucinogenic Activity"],"prefix":"10.1126","volume":"212","author":[{"given":"Bella T.","family":"Altura","sequence":"first","affiliation":[{"name":"Department of Physiology, State University of New York Downstate Medical Center, Brooklyn 11203"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burton M.","family":"Altura","sequence":"additional","affiliation":[{"name":"Department of Physiology, State University of New York Downstate Medical Center, Brooklyn 11203"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0304-3940(80)90168-8","volume":"20","year":"1980","unstructured":"ALTURA, B.T., WITHDRAWAL OF MAGNESIUM CAUSES VASOSPASM WHILE ELEVATED MAGNESIUM PRODUCES RELAXATION OF TONE IN CEREBRAL-ARTERIES, NEUROSCIENCE LETTERS 20: 323 (1980).","journal-title":"NEUROSCIENCE LETTERS"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1093\/ajcp\/72.5.795","volume":"72","year":"1979","unstructured":"BAILEY, D.N., PHENCYCLIDINE ABUSE - CLINICAL FINDINGS AND CONCENTRATIONS IN BIOLOGICAL-FLUIDS AFTER NONFATAL INTOXICATION, AMERICAN JOURNAL OF CLINICAL PATHOLOGY 72: 795 (1979).","journal-title":"AMERICAN JOURNAL OF CLINICAL PATHOLOGY"},{"key":"e_1_2_1_3_1","unstructured":"BOURNE P.G. 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