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The dose of DDP needed to eliminate the trypanosomes, 3 milligrams per kilogram of body weight per day for 7 days, was lethally toxic unless the animals received disulfiram orally and subcutaneous injections of physiologic saline, which reduced the acute renal necrosis caused by DDP alone. Some mild to moderate reversible renal damage was noted upon pathologic examination of the treated mice.<\/jats:p>","DOI":"10.1126\/science.7201165","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T18:30:32Z","timestamp":1160073032000},"page":"454-456","source":"Crossref","is-referenced-by-count":23,"title":["Cure of Mice Infected with\n            <i>Trypanosoma rhodesiense<\/i>\n            by\n            <i>cis<\/i>\n            -Diamminedichloroplatinum (ii) and Disulfiram Rescue"],"prefix":"10.1126","volume":"217","author":[{"given":"Michael S.","family":"Wysor","sequence":"first","affiliation":[{"name":"Department of Parasitology, Walter Reed Army Institute of Research, Washington, D.C. 20012"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard A.","family":"Zwelling","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E.","family":"Sanders","sequence":"additional","affiliation":[{"name":"Department of Pathology, Walter Reed Army Institute of Research, Washington, D.C. 20012"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie M.","family":"Grenan","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Walter Reed Army Institute of Research, Washington, D.C. 20012"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"4571","volume":"78","year":"1981","unstructured":"BAUM, S.G., TAXOL, A MICROTUBULE STABILIZING AGENT, BLOCKS THE REPLICATION OF TRYPANOSOMA-CRUZI, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 78: 4571 (1981).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES"},{"key":"e_1_2_1_2_1","first-page":"6611","volume":"76","year":"1979","unstructured":"BORCH, R.F., INHIBITION OF CIS-PLATINUM NEPHROTOXICITY BY DIETHYLDITHIOCARBAMATE RESCUE IN A RAT MODEL, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 76: 6611 (1979).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/0014-4894(80)90027-2","volume":"50","year":"1980","unstructured":"DESJARDINS, R.E., TRYPANOSOMA-RHODESIENSE - 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