{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:25:43Z","timestamp":1767705943852},"reference-count":22,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4476","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1980,12,19]]},"abstract":"<jats:p>Vasopressin neurons, transplanted from normal rat fetuses into the third ventricle of adult Brattleboro rats, alleviate the polydipsia and polyuria of the hosts. Determination of the antidiuretic activity of grafted neurons in hosts with congenital diabetes insipidus provides a convenient model for analyzing the development, plasticity, and function of transplanted central nervous system neurons in mammals.<\/jats:p>","DOI":"10.1126\/science.7434031","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T17:45:58Z","timestamp":1160070358000},"page":"1367-1369","source":"Crossref","is-referenced-by-count":165,"title":["Functional Development of Grafted Vasopressin Neurons"],"prefix":"10.1126","volume":"210","author":[{"given":"Don","family":"Gash","sequence":"first","affiliation":[{"name":"Department of Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642"},{"name":"Center for Brain Research, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"John R.","family":"Sladek","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642"},{"name":"Center for Brain Research, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celia D.","family":"Sladek","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642"},{"name":"Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0006-8993(79)90833-3","volume":"167","year":"1979","unstructured":"BEEBE, B.K., ULTRASTRUCTURAL EVIDENCE OF SYNAPTOGENESIS IN THE ADULT-RAT DENTATE GYRUS FROM BRAIN-STEM IMPLANTS, BRAIN RESEARCH 167: 391 (1979).","journal-title":"BRAIN RESEARCH"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/0006-8993(79)90961-2","volume":"170","year":"1979","unstructured":"BJORKLUND, A, FUNCTIONAL RE-INNERVATION OF RAT HIPPOCAMPUS BY LOCUS COERULEUS IMPLANTS, BRAIN RESEARCH 170: 409 (1979).","journal-title":"BRAIN RESEARCH"},{"key":"e_1_2_1_3_1","first-page":"R44","volume":"233","year":"1977","unstructured":"BUGGY, J, AMERICAN JOURNAL OF PHYSIOLOGY 233: R44 (1977).","journal-title":"AMERICAN JOURNAL OF PHYSIOLOGY"},{"key":"e_1_2_1_4_1","first-page":"147","year":"1955","unstructured":"Clemente, C. D., Regeneration in the Central Nervous System: 147 (1955).","journal-title":"Regeneration in the Central Nervous System"},{"key":"e_1_2_1_5_1","first-page":"137","year":"1979","unstructured":"Defendini, R., The Hypothalamus: 137 (1979).","journal-title":"The Hypothalamus"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0006-8993(80)90617-4","volume":"181","year":"1980","unstructured":"GASH, D, CYTODIFFERENTIATION OF THE SUPRAOPTIC NUCLEUS CORRELATED WITH VASOPRESSIN SYNTHESIS IN THE RAT, BRAIN RESEARCH 181: 345 (1980).","journal-title":"BRAIN RESEARCH"},{"key":"e_1_2_1_7_1","first-page":"11","volume":"1","year":"1980","unstructured":"GASH, D, VASOPRESSIN NEURONS GRAFTED INTO BRATTLEBORO RATS - VIABILITY AND ACTIVITY, PEPTIDES 1: 11 (1980).","journal-title":"PEPTIDES"},{"key":"e_1_2_1_8_1","first-page":"F100","volume":"237","year":"1979","unstructured":"GELLAI, M, AMERICAN JOURNAL OF PHYSIOLOGY 237: F100 (1979).","journal-title":"AMERICAN JOURNAL OF PHYSIOLOGY"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0014-4886(75)90168-5","volume":"48","year":"1975","unstructured":"GUTH, L, HISTORY OF CENTRAL NERVOUS-SYSTEM REGENERATION RESEARCH, EXPERIMENTAL NEUROLOGY 48: 3 (1975).","journal-title":"EXPERIMENTAL NEUROLOGY"},{"key":"e_1_2_1_10_1","first-page":"464","year":"1979","unstructured":"Henderson, S. R., 61st Annual Meeting of the Endocrine Society: 464 (1979).","journal-title":"61st Annual Meeting of the Endocrine Society"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/0006-8993(79)90566-3","volume":"165","year":"1979","unstructured":"JAEGER, C.B., EFFERENT FIBERS FROM TRANSPLANTED CEREBRAL-CORTEX OF RATS, BRAIN RESEARCH 165: 338 (1979).","journal-title":"BRAIN RESEARCH"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"R122","DOI":"10.1152\/ajpcell.1978.234.3.C122","volume":"234","year":"1978","unstructured":"JOHNSON, A. K., AMERICAN JOURNAL OF PHYSIOLOGY 234: R122 (1978).","journal-title":"AMERICAN JOURNAL OF PHYSIOLOGY"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1126\/science.472734","volume":"205","year":"1979","unstructured":"KALIL, K, REGROWTH OF SEVERED AXONS IN THE NEONATAL CENTRAL NERVOUS-SYSTEM - ESTABLISHMENT OF NORMAL CONNECTIONS, SCIENCE 205: 1158 (1979).","journal-title":"SCIENCE"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.959815"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.345442"},{"key":"e_1_2_1_16_1","first-page":"379","year":"1974","unstructured":"Moore, R. Y., Dynamics ofDegeneration and Growth in Neurons: 379 (1974).","journal-title":"Dynamics ofDegeneration and Growth in Neurons"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.571147"},{"key":"e_1_2_1_18_1","first-page":"285","volume":"179","year":"1977","unstructured":"SEIGER, A, QUANTITATION OF FIBER GROWTH IN TRANSPLANTED CENTRAL MONOAMINE NEURONS, CELL AND TISSUE RESEARCH 179: 285 (1977).","journal-title":"CELL AND TISSUE RESEARCH"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-98-5-1176"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-8993(76)91003-9","volume":"114","year":"1976","unstructured":"STENEVI, U, TRANSPLANTATION OF CENTRAL AND PERIPHERAL MONOAMINE NEURONS TO ADULT RAT-BRAIN - TECHNIQUES AND CONDITIONS FOR SURVIVAL, BRAIN RESEARCH 114: 1 (1976).","journal-title":"BRAIN RESEARCH"},{"key":"e_1_2_1_21_1","first-page":"217","volume":"205","year":"1980","unstructured":"STENEVI, U, DIFFERENTIATION OF EMBRYONIC HYPOTHALAMIC TRANSPLANTS CULTURED ON THE CHOROIDAL PIA IN BRAINS OF ADULT-RATS, CELL AND TISSUE RESEARCH 205: 217 (1980).","journal-title":"CELL AND TISSUE RESEARCH"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/0002-9343(67)90030-7","volume":"42","year":"1967","unstructured":"VALTIN, H, AM J MED 42: 314 (1967).","journal-title":"AM J MED"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.7434031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T04:12:07Z","timestamp":1705291927000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.7434031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,12,19]]},"references-count":22,"journal-issue":{"issue":"4476","published-print":{"date-parts":[[1980,12,19]]}},"alternative-id":["10.1126\/science.7434031"],"URL":"https:\/\/doi.org\/10.1126\/science.7434031","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,12,19]]}}}