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The results, although preliminary and limited to a single patient, suggest that reduction of plasma ornithine with a low arginine diet is beneficial in this disease.<\/jats:p>","DOI":"10.1126\/science.7444439","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T17:45:58Z","timestamp":1160070358000},"page":"1128-1131","source":"Crossref","is-referenced-by-count":44,"title":["Gyrate Atrophy of the Choroid and Retina: Improved Visual Function Following Reduction of Plasma Ornithine by Diet"],"prefix":"10.1126","volume":"210","author":[{"given":"Muriel I.","family":"Kaiser-Kupfer","sequence":"first","affiliation":[{"name":"Clinical Branch, National Eye Institute, Bethesda, Maryland 20205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco M.","family":"de Monasterio","sequence":"additional","affiliation":[{"name":"Clinical Branch, National Eye Institute, Bethesda, Maryland 20205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Valle","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute Laboratory and Departments of Pediatrics, Pharmacology and Experimental Therapeutics and Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MacKensie","family":"Walser","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute Laboratory and Departments of Pediatrics, Pharmacology and Experimental Therapeutics and Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saul","family":"Brusilow","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute Laboratory and Departments of Pediatrics, Pharmacology and Experimental Therapeutics and Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"117","volume":"17","year":"1978","unstructured":"ANDERSON, D.H., MAMMALIAN CONES - DISK SHEDDING, PHAGOCYTOSIS, AND RENEWAL, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 17: 117 (1978).","journal-title":"INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE"},{"key":"e_1_2_1_2_1","first-page":"411","volume":"19","year":"1980","unstructured":"BAICH, A, ORNITHINE AMINOTRANSFERASE IN CHICK-EMBRYO TISSUES, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 19: 411 (1980).","journal-title":"INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1001\/archpedi.1974.02110240138023","volume":"127","year":"1974","unstructured":"FELL, V, ORNITHINEMIA, HYPERAMMONEMIA, AND HOMOCITRULLINURIA - DISEASE ASSOCIATED WITH MENTAL-RETARDATION AND POSSIBLY CAUSED BY DEFECTIVE MITOCHONDRIAL TRANSPORT, AMERICAN JOURNAL OF DISEASES OF CHILDREN 127: 752 (1974).","journal-title":"AMERICAN JOURNAL OF DISEASES OF CHILDREN"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1001\/archopht.1976.03910030333017","volume":"94","year":"1976","unstructured":"GUNKEL, R.D., GANZFELD STIMULATOR FOR ELECTRORETINOGRAPHY, ARCHIVES OF OPHTHALMOLOGY 94: 669 (1976).","journal-title":"ARCHIVES OF OPHTHALMOLOGY"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0002-9394(14)75948-3","volume":"85","year":"1978","unstructured":"KAISERKUPFER, M.I., SPECIFIC ENZYME DEFECT IN GYRATE ATROPHY, AMERICAN JOURNAL OF OPHTHALMOLOGY 85: 200 (1978).","journal-title":"AMERICAN JOURNAL OF OPHTHALMOLOGY"},{"key":"e_1_2_1_6_1","first-page":"1180","volume":"297","year":"1977","unstructured":"KENNAWAY, N.G., GYRATE ATROPHY OF CHOROID AND RETINA - DEFICIENT ACTIVITY OF ORNITHINE KETOACID AMINOTRANSFERASE IN CULTURED SKIN FIBROBLASTS, NEW ENGLAND JOURNAL OF MEDICINE 297: 1180 (1977).","journal-title":"NEW ENGLAND JOURNAL OF MEDICINE"},{"key":"e_1_2_1_7_1","unstructured":"MCINNES R.R. 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