{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:30:19Z","timestamp":1792006219549,"version":"4.4.0"},"reference-count":9,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4489","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1981,3,27]]},"abstract":"<jats:p>\n            Chemical and dermatotoxicological investigations of the natural and processed resin of the Mexican rubber plant, guayule (\n            <jats:italic>Parthenium argentatum<\/jats:italic>\n            ), has established the presence of a sesquiterpene cinnamic acid ester (guayulin A) that is a potent elicitor of allergic contact dermatitis in experimental animals. The guayule contact allergen is comparable to the poison ivy skin allergens as an elicitor of dermatitis in sensitized guinea pigs.\n          <\/jats:p>","DOI":"10.1126\/science.7466403","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T17:45:58Z","timestamp":1160070358000},"page":"1444-1445","source":"Crossref","is-referenced-by-count":29,"title":["Potent Contact Allergen in the Rubber Plant Guayule (\n            <i>Parthenium argentatum<\/i>\n            )"],"prefix":"10.1126","volume":"211","author":[{"given":"Eloy","family":"Rodriguez","sequence":"first","affiliation":[{"name":"Phytochemistry Laboratory, Department of Developmental and Cell Biology, and Department of Ecology and Evolutionary Biology, University of California, Irvine 92717"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary W.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Phytochemistry Laboratory, Department of Developmental and Cell Biology, and Department of Ecology and Evolutionary Biology, University of California, Irvine 92717"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Phytochemistry Laboratory, Department of Developmental and Cell Biology, and Department of Ecology and Evolutionary Biology, University of California, Irvine 92717"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"370","DOI":"10.4049\/jimmunol.99.2.370","volume":"99","year":"1967","unstructured":"BAER, H, DELAYED CONTACT SENSITIVITY TO CATECHOLS .3. 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GUINEA PIG MAXIMIZATION TEST, JOURNAL OF INVESTIGATIVE DERMATOLOGY 52: 268 (1969).","journal-title":"JOURNAL OF INVESTIGATIVE DERMATOLOGY"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1600-0536.1977.tb03632.x","volume":"3","year":"1977","unstructured":"RODRIGUEZ, E, ROLE OF SESQUITERPENE LACTONES IN CONTACT HYPERSENSITIVITY TO SOME NORTH AND SOUTH-AMERICAN SPECIES OF FEVERFEW (PARTHENIUM - COMPOSITAE), CONTACT DERMATITIS 3: 155 (1977).","journal-title":"CONTACT DERMATITIS"},{"key":"e_1_2_1_7_1","first-page":"332","volume":"2","year":"1970","unstructured":"ROMO, J, REVISTA LATINOAMERICANA DE QUIMICA 2: 332 (1970).","journal-title":"REVISTA LATINOAMERICANA DE QUIMICA"},{"key":"e_1_2_1_8_1","first-page":"778","volume":"38","year":"1938","unstructured":"SMITH, L.M., ARCHIV FUR DERMATOLOGIE UND SYPHILIS 38: 778 (1938).","journal-title":"ARCHIV FUR DERMATOLOGIE UND SYPHILIS"},{"key":"e_1_2_1_9_1","first-page":"672","volume":"36","year":"1977","unstructured":"TOWERS, GHN, BIOLOGY AND CHEMISTRY OF PARTHENIUM-HYSTEROPHORUS-L, A PROBLEM WEED IN INDIA, JOURNAL OF SCIENTIFIC & INDUSTRIAL RESEARCH 36: 672 (1977).","journal-title":"JOURNAL OF SCIENTIFIC & INDUSTRIAL RESEARCH"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.7466403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T05:33:23Z","timestamp":1705296803000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.7466403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,3,27]]},"references-count":9,"journal-issue":{"issue":"4489","published-print":{"date-parts":[[1981,3,27]]}},"alternative-id":["10.1126\/science.7466403"],"URL":"https:\/\/doi.org\/10.1126\/science.7466403","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,3,27]]}}}