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In HTLV-I-infected cord blood lymphocytes, the transition from IL-2-dependent to IL-2-independent growth correlated with the acquisition of a constitutively activated Jak-STAT pathway, which suggests that this pathway participates in HTLV-I-mediated T cell transformation.<\/jats:p>","DOI":"10.1126\/science.7604283","type":"journal-article","created":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T18:19:42Z","timestamp":1161973182000},"page":"79-81","source":"Crossref","is-referenced-by-count":458,"title":["Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I"],"prefix":"10.1126","volume":"269","author":[{"given":"Thi-Sau","family":"Migone","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Xin","family":"Lin","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Cereseto","sequence":"additional","affiliation":[{"name":"Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Mulloy","sequence":"additional","affiliation":[{"name":"Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"O'Shea","sequence":"additional","affiliation":[{"name":"Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genoveffa","family":"Franchini","sequence":"additional","affiliation":[{"name":"Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren J.","family":"Leonard","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6320374"},{"key":"e_1_2_1_2_1","first-page":"4940","volume":"91","year":"1994","unstructured":"BAMFORD, R.N., THE INTERLEUKIN (IL)-2 RECEPTOR-BETA CHAIN IS SHARED BY IL-2 AND A CYTOKINE, PROVISIONALLY DESIGNATED IL-T, THAT STIMULATES T-CELL PROLIFERATION AND THE INDUCTION OF LYMPHOKINE-ACTIVATED KILLER-CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91: 4940 (1994).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"5605","DOI":"10.1002\/j.1460-2075.1994.tb06898.x","volume":"13","year":"1994","unstructured":"BEADLING, C, ACTIVATION OF JAK KINASES AND STAT PROTEINS BY INTERLEUKIN-2 AND INTERFERON-ALPHA, BUT NOT THE T-CELL ANTIGEN RECEPTOR, IN HUMAN T-LYMPHOCYTES, EMBO JOURNAL 13: 5605 (1994).","journal-title":"EMBO JOURNAL"},{"key":"e_1_2_1_4_1","first-page":"3005","volume":"89","year":"1992","unstructured":"BERNEMAN, Z.N., EXPRESSION OF ALTERNATIVELY SPLICED HUMAN T-LYMPHOTROPIC VIRUS TYPE-I PX MESSENGER-RNA IN INFECTED CELL-LINES AND IN PRIMARY UNCULTURED CELLS FROM PATIENTS WITH ADULT T-CELL LEUKEMIA LYMPHOMA AND HEALTHY CARRIERS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 89: 3005 (1992).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7973657"},{"key":"e_1_2_1_6_1","first-page":"4935","volume":"91","year":"1994","unstructured":"BURTON, J.D., A LYMPHOKINE, PROVISIONALLY DESIGNATED INTERLEUKIN-T AND PRODUCED BY A HUMAN ADULT T-CELL LEUKEMIA LINE, STIMULATES T-CELL PROLIFERATION AND THE INDUCTION OF LYMPHOKINE-ACTIVATED KILLER-CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91: 4935 (1994).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1128\/jvi.66.3.1737-1745.1992","volume":"66","year":"1992","unstructured":"CIMINALE, V, COMPLEX SPLICING IN THE HUMAN T-CELL LEUKEMIA-VIRUS (HTLV) FAMILY OF RETROVIRUSES - 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