{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:28:19Z","timestamp":1791325699349,"version":"4.3.1"},"reference-count":35,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5118","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1993,7,9]]},"abstract":"<jats:p>\n            Complementary DNAs (cDNAs) from\n            <jats:italic>mSlo<\/jats:italic>\n            , a gene encoding calcium-activated potassium channels, were isolated from mouse brain and skeletal muscle, sequenced, and expressed in\n            <jats:italic>Xenopus<\/jats:italic>\n            oocytes. The\n            <jats:italic>mSlo<\/jats:italic>\n            -encoded channel resembled \"maxi\" or BK (high conductance) channel types; single channel conductance was 272 picosiemens with symmetrical potassium concentrations. Whole cell and single channel currents were blocked by charybdotoxin, iberiotoxin, and tetraethylammonium ion. A large number of variant\n            <jats:italic>mSlo<\/jats:italic>\n            cDNAs were isolated, indicating that several diverse mammalian BK channel types are produced by a single gene.\n          <\/jats:p>","DOI":"10.1126\/science.7687074","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T23:05:09Z","timestamp":1160089509000},"page":"221-224","source":"Crossref","is-referenced-by-count":560,"title":["<i>mSlo<\/i>\n            , a Complex Mouse Gene Encoding \"Maxi\" Calcium-Activated Potassium Channels"],"prefix":"10.1126","volume":"261","author":[{"given":"Alice","family":"Butler","sequence":"first","affiliation":[{"name":"Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Tsunoda","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"McCobb","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aguan","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Salkoff","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology and Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90160-F"},{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1857984"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0166-2236(87)90101-9","volume":"10","year":"1987","unstructured":"BLATZ, A.L., CALCIUM-ACTIVATED POTASSIUM CHANNELS, TRENDS IN NEUROSCIENCES 10: 463 (1987).","journal-title":"TRENDS IN NEUROSCIENCES"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.ph.52.030190.001213","volume":"52","year":"1990","unstructured":"BROWN, A.M., IONIC CHANNELS AND THEIR REGULATION BY G-PROTEIN SUBUNITS, ANNUAL REVIEW OF PHYSIOLOGY 52: 197 (1990).","journal-title":"ANNUAL REVIEW OF PHYSIOLOGY"},{"key":"e_1_2_1_5_1","unstructured":"BUTLER A unpublished data."},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0070-2161(08)60809-6","volume":"39","year":"1991","unstructured":"CAHALAN, M. 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